引用雅各布·海伦的话:

The proper use of __slots__ is to save space in objects. Instead of having a dynamic dict that allows adding attributes to objects at anytime, there is a static structure which does not allow additions after creation. [This use of __slots__ eliminates the overhead of one dict for every object.] While this is sometimes a useful optimization, it would be completely unnecessary if the Python interpreter was dynamic enough so that it would only require the dict when there actually were additions to the object. Unfortunately there is a side effect to slots. They change the behavior of the objects that have slots in a way that can be abused by control freaks and static typing weenies. This is bad, because the control freaks should be abusing the metaclasses and the static typing weenies should be abusing decorators, since in Python, there should be only one obvious way of doing something. Making CPython smart enough to handle saving space without __slots__ is a major undertaking, which is probably why it is not on the list of changes for P3k (yet).

如果你要实例化很多(成百上千)同一个类的对象，你会想要使用__slots__。__slots__仅作为内存优化工具存在。

强烈建议使用__slots__来约束属性创建。

使用__slots__ pickle对象将无法使用默认的(最古老的)pickle协议;有必要指定一个更高的版本。

python的其他一些自省特性也可能受到不利影响。

引用雅各布·海伦的话:

The proper use of __slots__ is to save space in objects. Instead of having a dynamic dict that allows adding attributes to objects at anytime, there is a static structure which does not allow additions after creation. [This use of __slots__ eliminates the overhead of one dict for every object.] While this is sometimes a useful optimization, it would be completely unnecessary if the Python interpreter was dynamic enough so that it would only require the dict when there actually were additions to the object. Unfortunately there is a side effect to slots. They change the behavior of the objects that have slots in a way that can be abused by control freaks and static typing weenies. This is bad, because the control freaks should be abusing the metaclasses and the static typing weenies should be abusing decorators, since in Python, there should be only one obvious way of doing something. Making CPython smart enough to handle saving space without __slots__ is a major undertaking, which is probably why it is not on the list of changes for P3k (yet).

除了在这里的其他答案中描述的无数优点-内存意识的紧凑实例，比更易变的__dict__承载实例更不容易出错等等-我发现使用__slots__提供了更清晰的类声明，因为类的实例变量显式地公开。

为了解决__slots__声明的继承问题，我使用了这个元类:

import abc

class Slotted(abc.ABCMeta):
    
    """ A metaclass that ensures its classes, and all subclasses,
        will be slotted types.
    """
    
    def __new__(metacls, name, bases, attributes, **kwargs):
        """ Override for `abc.ABCMeta.__new__(…)` setting up a
            derived slotted class.
        """
        if '__slots__' not in attributes:
            attributes['__slots__'] = tuple()
        
        return super(Slotted, metacls).__new__(metacls, name, # type: ignore
                                                        bases,
                                                        attributes,
                                                      **kwargs)

…如果在继承塔中声明为基类的元类，则确保从该基类派生的所有内容都将正确继承__slots__属性，即使中间类没有声明任何属性。像这样:

# note no __slots__ declaration necessary with the metaclass:
class Base(metaclass=Slotted):
    pass

# class is properly slotted, no __dict__:
class Derived(Base):
    __slots__ = 'slot', 'another_slot'

# class is also properly slotted:
class FurtherDerived(Derived):
    pass

Another somewhat obscure use of __slots__ is to add attributes to an object proxy from the ProxyTypes package, formerly part of the PEAK project. Its ObjectWrapper allows you to proxy another object, but intercept all interactions with the proxied object. It is not very commonly used (and no Python 3 support), but we have used it to implement a thread-safe blocking wrapper around an async implementation based on tornado that bounces all access to the proxied object through the ioloop, using thread-safe concurrent.Future objects to synchronise and return results.

默认情况下，对代理对象的任何属性访问都将为您提供代理对象的结果。如果你需要在代理对象上添加一个属性，可以使用__slots__。

from peak.util.proxies import ObjectWrapper

class Original(object):
    def __init__(self):
        self.name = 'The Original'

class ProxyOriginal(ObjectWrapper):

    __slots__ = ['proxy_name']

    def __init__(self, subject, proxy_name):
        # proxy_info attributed added directly to the
        # Original instance, not the ProxyOriginal instance
        self.proxy_info = 'You are proxied by {}'.format(proxy_name)

        # proxy_name added to ProxyOriginal instance, since it is
        # defined in __slots__
        self.proxy_name = proxy_name

        super(ProxyOriginal, self).__init__(subject)

if __name__ == "__main__":
    original = Original()
    proxy = ProxyOriginal(original, 'Proxy Overlord')

    # Both statements print "The Original"
    print "original.name: ", original.name
    print "proxy.name: ", proxy.name

    # Both statements below print 
    # "You are proxied by Proxy Overlord", since the ProxyOriginal
    # __init__ sets it to the original object 
    print "original.proxy_info: ", original.proxy_info
    print "proxy.proxy_info: ", proxy.proxy_info

    # prints "Proxy Overlord"
    print "proxy.proxy_name: ", proxy.proxy_name
    # Raises AttributeError since proxy_name is only set on 
    # the proxy object
    print "original.proxy_name: ", proxy.proxy_name

除了其他答案，这里还有一个使用__slots__的例子:

>>> class Test(object):   #Must be new-style class!
...  __slots__ = ['x', 'y']
... 
>>> pt = Test()
>>> dir(pt)
['__class__', '__delattr__', '__doc__', '__getattribute__', '__hash__', 
 '__init__', '__module__', '__new__', '__reduce__', '__reduce_ex__', 
 '__repr__', '__setattr__', '__slots__', '__str__', 'x', 'y']
>>> pt.x
Traceback (most recent call last):
  File "<stdin>", line 1, in <module>
AttributeError: x
>>> pt.x = 1
>>> pt.x
1
>>> pt.z = 2
Traceback (most recent call last):
  File "<stdin>", line 1, in <module>
AttributeError: 'Test' object has no attribute 'z'
>>> pt.__dict__
Traceback (most recent call last):
  File "<stdin>", line 1, in <module>
AttributeError: 'Test' object has no attribute '__dict__'
>>> pt.__slots__
['x', 'y']

因此，要实现__slots__，它只需要额外的一行(并使您的类成为一个新样式的类，如果它还不是的话)。通过这种方式，您可以将这些类的内存占用减少5倍，代价是必须编写自定义pickle代码(如果需要的话)。