只需按所需顺序分配列名：

In [39]: df
Out[39]: 
          0         1         2         3         4  mean
0  0.172742  0.915661  0.043387  0.712833  0.190717     1
1  0.128186  0.424771  0.590779  0.771080  0.617472     1
2  0.125709  0.085894  0.989798  0.829491  0.155563     1
3  0.742578  0.104061  0.299708  0.616751  0.951802     1
4  0.721118  0.528156  0.421360  0.105886  0.322311     1
5  0.900878  0.082047  0.224656  0.195162  0.736652     1
6  0.897832  0.558108  0.318016  0.586563  0.507564     1
7  0.027178  0.375183  0.930248  0.921786  0.337060     1
8  0.763028  0.182905  0.931756  0.110675  0.423398     1
9  0.848996  0.310562  0.140873  0.304561  0.417808     1

In [40]: df = df[['mean', 4,3,2,1]]

现在，“mean”列出现在前面：

In [41]: df
Out[41]: 
   mean         4         3         2         1
0     1  0.190717  0.712833  0.043387  0.915661
1     1  0.617472  0.771080  0.590779  0.424771
2     1  0.155563  0.829491  0.989798  0.085894
3     1  0.951802  0.616751  0.299708  0.104061
4     1  0.322311  0.105886  0.421360  0.528156
5     1  0.736652  0.195162  0.224656  0.082047
6     1  0.507564  0.586563  0.318016  0.558108
7     1  0.337060  0.921786  0.930248  0.375183
8     1  0.423398  0.110675  0.931756  0.182905
9     1  0.417808  0.304561  0.140873  0.310562

这里有一个函数可以对任意数量的列执行此操作。

def mean_first(df):
    ncols = df.shape[1]        # Get the number of columns
    index = list(range(ncols)) # Create an index to reorder the columns
    index.insert(0,ncols)      # This puts the last column at the front
    return(df.assign(mean=df.mean(1)).iloc[:,index]) # new df with last column (mean) first

您可以使用可用于两个轴的重新索引：

df
#           0         1         2         3         4      mean
# 0  0.943825  0.202490  0.071908  0.452985  0.678397  0.469921
# 1  0.745569  0.103029  0.268984  0.663710  0.037813  0.363821
# 2  0.693016  0.621525  0.031589  0.956703  0.118434  0.484254
# 3  0.284922  0.527293  0.791596  0.243768  0.629102  0.495336
# 4  0.354870  0.113014  0.326395  0.656415  0.172445  0.324628
# 5  0.815584  0.532382  0.195437  0.829670  0.019001  0.478415
# 6  0.944587  0.068690  0.811771  0.006846  0.698785  0.506136
# 7  0.595077  0.437571  0.023520  0.772187  0.862554  0.538182
# 8  0.700771  0.413958  0.097996  0.355228  0.656919  0.444974
# 9  0.263138  0.906283  0.121386  0.624336  0.859904  0.555009

df.reindex(['mean', *range(5)], axis=1)

#        mean         0         1         2         3         4
# 0  0.469921  0.943825  0.202490  0.071908  0.452985  0.678397
# 1  0.363821  0.745569  0.103029  0.268984  0.663710  0.037813
# 2  0.484254  0.693016  0.621525  0.031589  0.956703  0.118434
# 3  0.495336  0.284922  0.527293  0.791596  0.243768  0.629102
# 4  0.324628  0.354870  0.113014  0.326395  0.656415  0.172445
# 5  0.478415  0.815584  0.532382  0.195437  0.829670  0.019001
# 6  0.506136  0.944587  0.068690  0.811771  0.006846  0.698785
# 7  0.538182  0.595077  0.437571  0.023520  0.772187  0.862554
# 8  0.444974  0.700771  0.413958  0.097996  0.355228  0.656919
# 9  0.555009  0.263138  0.906283  0.121386  0.624336  0.859904

一种简单的方法是用列列表重新分配数据帧，根据需要重新排列。

这就是你现在拥有的：

In [6]: df
Out[6]:
          0         1         2         3         4      mean
0  0.445598  0.173835  0.343415  0.682252  0.582616  0.445543
1  0.881592  0.696942  0.702232  0.696724  0.373551  0.670208
2  0.662527  0.955193  0.131016  0.609548  0.804694  0.632596
3  0.260919  0.783467  0.593433  0.033426  0.512019  0.436653
4  0.131842  0.799367  0.182828  0.683330  0.019485  0.363371
5  0.498784  0.873495  0.383811  0.699289  0.480447  0.587165
6  0.388771  0.395757  0.745237  0.628406  0.784473  0.588529
7  0.147986  0.459451  0.310961  0.706435  0.100914  0.345149
8  0.394947  0.863494  0.585030  0.565944  0.356561  0.553195
9  0.689260  0.865243  0.136481  0.386582  0.730399  0.561593

In [7]: cols = df.columns.tolist()

In [8]: cols
Out[8]: [0L, 1L, 2L, 3L, 4L, 'mean']

按任意方式重新排列列。这是我将最后一个元素移动到第一个位置的方式：

In [12]: cols = cols[-1:] + cols[:-1]

In [13]: cols
Out[13]: ['mean', 0L, 1L, 2L, 3L, 4L]

然后重新排序数据帧，如下所示：

In [16]: df = df[cols]  #    OR    df = df.ix[:, cols]

In [17]: df
Out[17]:
       mean         0         1         2         3         4
0  0.445543  0.445598  0.173835  0.343415  0.682252  0.582616
1  0.670208  0.881592  0.696942  0.702232  0.696724  0.373551
2  0.632596  0.662527  0.955193  0.131016  0.609548  0.804694
3  0.436653  0.260919  0.783467  0.593433  0.033426  0.512019
4  0.363371  0.131842  0.799367  0.182828  0.683330  0.019485
5  0.587165  0.498784  0.873495  0.383811  0.699289  0.480447
6  0.588529  0.388771  0.395757  0.745237  0.628406  0.784473
7  0.345149  0.147986  0.459451  0.310961  0.706435  0.100914
8  0.553195  0.394947  0.863494  0.585030  0.565944  0.356561
9  0.561593  0.689260  0.865243  0.136481  0.386582  0.730399

您可以执行以下操作（从Aman的答案中借用零件）：

cols = df.columns.tolist()
cols.insert(0, cols.pop(-1))

cols
>>>['mean', 0L, 1L, 2L, 3L, 4L]

df = df[cols]

DataFrame.sort_index（axis=1）非常干净。请在此处检查文档。然后凹入