string xyz = "1   2   3   4   5";
xyz = string.Join( " ", xyz.Split( new char[] { ' ' }, StringSplitOptions.RemoveEmptyEntries ));

string sentence = "This is a sentence with multiple    spaces";
RegexOptions options = RegexOptions.None;
Regex regex = new Regex("[ ]{2,}", options);     
sentence = regex.Replace(sentence, " ");

许多答案都提供了正确的输出，但对于那些寻找最佳性能的人来说，我确实将Nolanar的答案(性能的最佳答案)提高了大约10%。

public static string MergeSpaces(this string str)
{

    if (str == null)
    {
        return null;
    }
    else
    {
        StringBuilder stringBuilder = new StringBuilder(str.Length);

        int i = 0;
        foreach (char c in str)
        {
            if (c != ' ' || i == 0 || str[i - 1] != ' ')
                stringBuilder.Append(c);
            i++;
        }
        return stringBuilder.ToString();
    }

}

// Mysample string
string str ="hi you           are          a demo";

//Split the words based on white sapce
var demo= str .Split(' ').Where(s => !string.IsNullOrWhiteSpace(s));
        
//Join the values back and add a single space in between
str = string.Join(" ", demo);
// output: string str ="hi you are a demo";

string xyz = "1   2   3   4   5";
xyz = string.Join( " ", xyz.Split( new char[] { ' ' }, StringSplitOptions.RemoveEmptyEntries ));

我刚刚写了一个我喜欢的新Join，所以我想我应该重新回答，用它:

public static string Join<T>(this IEnumerable<T> source, string separator)
{
    return string.Join(separator, source.Select(e => e.ToString()).ToArray());
}

关于它的一个很酷的事情是，它通过在元素上调用ToString()来处理不是字符串的集合。用法还是一样的:

//...

string s = "     1  2    4 5".Split (
    " ".ToCharArray(), 
    StringSplitOptions.RemoveEmptyEntries
    ).Join (" ");