string sentence = "This is a sentence with multiple    spaces";
RegexOptions options = RegexOptions.None;
Regex regex = new Regex("[ ]{2,}", options);     
sentence = regex.Replace(sentence, " ");

许多答案都提供了正确的输出，但对于那些寻找最佳性能的人来说，我确实将Nolanar的答案(性能的最佳答案)提高了大约10%。

public static string MergeSpaces(this string str)
{

    if (str == null)
    {
        return null;
    }
    else
    {
        StringBuilder stringBuilder = new StringBuilder(str.Length);

        int i = 0;
        foreach (char c in str)
        {
            if (c != ' ' || i == 0 || str[i - 1] != ' ')
                stringBuilder.Append(c);
            i++;
        }
        return stringBuilder.ToString();
    }

}

string sentence = "This is a sentence with multiple    spaces";
RegexOptions options = RegexOptions.None;
Regex regex = new Regex("[ ]{2,}", options);     
sentence = regex.Replace(sentence, " ");

另一种使用LINQ的方法:

 var list = str.Split(' ').Where(s => !string.IsNullOrWhiteSpace(s));
 str = string.Join(" ", list);

您可以使用RemoveDoubleSpaces()这样的方法创建StringsExtensions文件。

StringsExtensions.cs

public static string RemoveDoubleSpaces(this string value)  
{
  Regex regex = new Regex("[ ]{2,}", RegexOptions.None);
  value = regex.Replace(value, " ");

  // this removes space at the end of the value (like "demo ")
  // and space at the start of the value (like " hi")
  value = value.Trim(' ');

  return value;
}

然后你可以这样使用它:

string stringInput =" hi here     is  a demo ";

string stringCleaned = stringInput.RemoveDoubleSpaces();

根据Joel的说法，巩固其他答案，并希望随着我的前进略有改善:

你可以用Regex.Replace()来实现:

string s = Regex.Replace (
    "   1  2    4 5", 
    @"[ ]{2,}", 
    " "
    );

或者使用String.Split():

static class StringExtensions
{
    public static string Join(this IList<string> value, string separator)
    {
        return string.Join(separator, value.ToArray());
    }
}

//...

string s = "     1  2    4 5".Split (
    " ".ToCharArray(), 
    StringSplitOptions.RemoveEmptyEntries
    ).Join (" ");