不使用正则表达式:

while (myString.IndexOf("  ", StringComparison.CurrentCulture) != -1)
{
    myString = myString.Replace("  ", " ");
}

可以在短弦上使用，但在有很多空格的长弦上表现不佳。

string xyz = "1   2   3   4   5";
xyz = string.Join( " ", xyz.Split( new char[] { ' ' }, StringSplitOptions.RemoveEmptyEntries ));

myString = Regex.Replace(myString, " {2,}", " ");

要不耍流氓?

public static string MinimizeWhiteSpace(
    this string _this)
    {
        if (_this != null)
        {
            var returned = new StringBuilder();
            var inWhiteSpace = false;
            var length = _this.Length;
            for (int i = 0; i < length; i++)
            {
                var character = _this[i];
                if (char.IsWhiteSpace(character))
                {
                    if (!inWhiteSpace)
                    {
                        inWhiteSpace = true;
                        returned.Append(' ');
                    }
                }
                else
                {
                    inWhiteSpace = false;
                    returned.Append(character);
                }
            }
            return returned.ToString();
        }
        else
        {
            return null;
        }
    }

string sentence = "This is a sentence with multiple    spaces";
RegexOptions options = RegexOptions.None;
Regex regex = new Regex("[ ]{2,}", options);     
sentence = regex.Replace(sentence, " ");

我可以用这个删除空格

while word.contains("  ")  //double space
   word = word.Replace("  "," "); //replace double space by single space.
word = word.trim(); //to remove single whitespces from start & end.