混合StringBuilder和Enumerable.Aggregate()作为字符串的扩展方法:

using System;
using System.Linq;
using System.Text;

public static class StringExtension
{
    public static string CondenseSpaces(this string s)
    {
        return s.Aggregate(new StringBuilder(), (acc, c) =>
        {
            if (c != ' ' || acc.Length == 0 || acc[acc.Length - 1] != ' ')
                acc.Append(c);
            return acc;
        }).ToString();
    }

    public static void Main()
    {
        const string input = "     (five leading spaces)     (five internal spaces)     (five trailing spaces)     ";
        
        Console.WriteLine(" Input: \"{0}\"", input);
        Console.WriteLine("Output: \"{0}\"", StringExtension.CondenseSpaces(input));
    }
}

执行这个程序产生以下输出:

 Input: "     (five leading spaces)     (five internal spaces)     (five trailing spaces)     "
Output: " (five leading spaces) (five internal spaces) (five trailing spaces) "

使用正则表达式模式

    [ ]+    #only space

   var text = Regex.Replace(inputString, @"[ ]+", " ");

string sentence = "This is a sentence with multiple    spaces";
RegexOptions options = RegexOptions.None;
Regex regex = new Regex("[ ]{2,}", options);     
sentence = regex.Replace(sentence, " ");

myString = Regex.Replace(myString, " {2,}", " ");

老派：

string oldText = "   1 2  3   4    5     ";
string newText = oldText
                    .Replace("  ", " " + (char)22 )
                    .Replace( (char)22 + " ", "" )
                    .Replace( (char)22 + "", "" );

Assert.That( newText, Is.EqualTo( " 1 2 3 4 5 " ) );

我认为Matt的答案是最好的，但我不认为它是完全正确的。如果你想替换换行符，你必须使用:

myString = Regex.Replace(myString, @"\s+", " ", RegexOptions.Multiline);