一个新的使用互斥和IPC的东西，也传递任何命令行参数到运行的实例，是WPF单实例应用程序。

[我在下面提供了控制台和wpf应用程序的示例代码。]

在创建命名的Mutex实例后，只需检查createdNew变量的值(示例如下!)。

布尔值createdNew将返回false:

如果命名为“YourApplicationNameHere”的互斥锁实例已经存在 在系统某处创建

布尔值createdNew将返回true:

如果这是第一个名为“YourApplicationNameHere”的互斥锁 系统。

控制台应用程序-示例:

static Mutex m = null;

static void Main(string[] args)
{
    const string mutexName = "YourApplicationNameHere";
    bool createdNew = false;

    try
    {
        // Initializes a new instance of the Mutex class with a Boolean value that indicates 
        // whether the calling thread should have initial ownership of the mutex, a string that is the name of the mutex, 
        // and a Boolean value that, when the method returns, indicates whether the calling thread was granted initial ownership of the mutex.

        using (m = new Mutex(true, mutexName, out createdNew))
        {
            if (!createdNew)
            {
                Console.WriteLine("instance is alreday running... shutting down !!!");
                Console.Read();
                return; // Exit the application
            }

            // Run your windows forms app here
            Console.WriteLine("Single instance app is running!");
            Console.ReadLine();
        }


    }
    catch (Exception ex)
    {

        Console.WriteLine(ex.Message);
        Console.ReadLine();
    }
}

WPF-Example:

public partial class App : Application
{
static Mutex m = null;

protected override void OnStartup(StartupEventArgs e)
{

    const string mutexName = "YourApplicationNameHere";
    bool createdNew = false;

    try
    {
        // Initializes a new instance of the Mutex class with a Boolean value that indicates 
        // whether the calling thread should have initial ownership of the mutex, a string that is the name of the mutex, 
        // and a Boolean value that, when the method returns, indicates whether the calling thread was granted initial ownership of the mutex.

        m = new Mutex(true, mutexName, out createdNew);

        if (!createdNew)
        {
            Current.Shutdown(); // Exit the application
        }

    }
    catch (Exception)
    {
        throw;
    }

    base.OnStartup(e);
}


protected override void OnExit(ExitEventArgs e)
{
    if (m != null)
    {
        m.Dispose();
    }
    base.OnExit(e);
}
}

这是我的两分钱

 static class Program
    {
        [STAThread]
        static void Main()
        {
            bool createdNew;
            using (new Mutex(true, "MyApp", out createdNew))
            {
                if (createdNew) {
                    Application.EnableVisualStyles();
                    Application.SetCompatibleTextRenderingDefault(false);
                    var mainClass = new SynGesturesLogic();
                    Application.ApplicationExit += mainClass.tray_exit;
                    Application.Run();
                }
                else
                {
                    var current = Process.GetCurrentProcess();
                    foreach (var process in Process.GetProcessesByName(current.ProcessName).Where(process => process.Id != current.Id))
                    {
                        NativeMethods.SetForegroundWindow(process.MainWindowHandle);
                        break;
                    }
                }
            }
        }
    }

我在这里找不到一个简单的解决方案，所以我希望有人会喜欢这个:

更新2018-09-20

把这段代码放在Program.cs中:

using System.Diagnostics;

static void Main()
{
    Process thisProcess = Process.GetCurrentProcess();
    Process[] allProcesses = Process.GetProcessesByName(thisProcess.ProcessName);
    if (allProcesses.Length > 1)
    {
        // Don't put a MessageBox in here because the user could spam this MessageBox.
        return;
    }

    // Optional code. If you don't want that someone runs your ".exe" with a different name:

    string exeName = AppDomain.CurrentDomain.FriendlyName;
    // in debug mode, don't forget that you don't use your normal .exe name.
    // Debug uses the .vshost.exe.
    if (exeName != "the name of your executable.exe") 
    {
        // You can add a MessageBox here if you want.
        // To point out to users that the name got changed and maybe what the name should be or something like that^^ 
        MessageBox.Show("The executable name should be \"the name of your executable.exe\"", 
            "Wrong executable name", MessageBoxButtons.OK, MessageBoxIcon.Error);
        return;
    }

    // Following code is default code:
    Application.EnableVisualStyles();
    Application.SetCompatibleTextRenderingDefault(false);
    Application.Run(new MainForm());
}

代码c# . net单实例应用程序作为标记答案的参考是一个很好的开始。

然而，我发现它不能很好地处理已经存在的实例打开了一个模态对话框的情况，无论该对话框是托管的(像另一个表单，如about框)，还是非托管的(像OpenFileDialog，甚至在使用标准的. net类时)。使用原始代码，主表单被激活，但模态表单保持不激活状态，这看起来很奇怪，而且用户必须点击它才能继续使用应用程序。

因此，我已经创建了一个SingleInstance实用程序类来为Winforms和WPF应用程序自动处理所有这些。

Winforms:

1)像这样修改Program类:

static class Program
{
    public static readonly SingleInstance Singleton = new SingleInstance(typeof(Program).FullName);

    [STAThread]
    static void Main(string[] args)
    {
        // NOTE: if this always return false, close & restart Visual Studio
        // this is probably due to the vshost.exe thing
        Singleton.RunFirstInstance(() =>
        {
            SingleInstanceMain(args);
        });
    }

    public static void SingleInstanceMain(string[] args)
    {
        // standard code that was in Main now goes here
        Application.EnableVisualStyles();
        Application.SetCompatibleTextRenderingDefault(false);
        Application.Run(new Form1());
    }
}

2)像这样修改主窗口类:

public partial class Form1 : Form
{
    public Form1()
    {
        InitializeComponent();
    }

    protected override void WndProc(ref Message m)
    {
        // if needed, the singleton will restore this window
        Program.Singleton.OnWndProc(this, m, true);

        // TODO: handle specific messages here if needed
        base.WndProc(ref m);
    }
}

WPF:

1)像这样修改App页面(并确保你将其构建动作设置为page，以便能够重新定义Main方法):

public partial class App : Application
{
    public static readonly SingleInstance Singleton = new SingleInstance(typeof(App).FullName);

    [STAThread]
    public static void Main(string[] args)
    {
        // NOTE: if this always return false, close & restart Visual Studio
        // this is probably due to the vshost.exe thing
        Singleton.RunFirstInstance(() =>
        {
            SingleInstanceMain(args);
        });
    }

    public static void SingleInstanceMain(string[] args)
    {
        // standard code that was in Main now goes here
        App app = new App();
        app.InitializeComponent();
        app.Run();
    }
}

2)像这样修改主窗口类:

public partial class MainWindow : Window
{
    private HwndSource _source;

    public MainWindow()
    {
        InitializeComponent();
    }

    protected override void OnSourceInitialized(EventArgs e)
    {
        base.OnSourceInitialized(e);
        _source = (HwndSource)PresentationSource.FromVisual(this);
        _source.AddHook(HwndSourceHook);
    }

    protected virtual IntPtr HwndSourceHook(IntPtr hwnd, int msg, IntPtr wParam, IntPtr lParam, ref bool handled)
    {
        // if needed, the singleton will restore this window
        App.Singleton.OnWndProc(hwnd, msg, wParam, lParam, true, true);

        // TODO: handle other specific message
        return IntPtr.Zero;
    }

这里是实用程序类:

using System;
using System.ComponentModel;
using System.Runtime.InteropServices;
using System.Threading;

namespace SingleInstanceUtilities
{
    public sealed class SingleInstance
    {
        private const int HWND_BROADCAST = 0xFFFF;

        [DllImport("user32.dll")]
        private static extern bool PostMessage(IntPtr hwnd, int msg, IntPtr wparam, IntPtr lparam);

        [DllImport("user32.dll", CharSet = CharSet.Unicode)]
        private static extern int RegisterWindowMessage(string message);

        [DllImport("user32.dll")]
        private static extern bool SetForegroundWindow(IntPtr hWnd);

        public SingleInstance(string uniqueName)
        {
            if (uniqueName == null)
                throw new ArgumentNullException("uniqueName");

            Mutex = new Mutex(true, uniqueName);
            Message = RegisterWindowMessage("WM_" + uniqueName);
        }

        public Mutex Mutex { get; private set; }
        public int Message { get; private set; }

        public void RunFirstInstance(Action action)
        {
            RunFirstInstance(action, IntPtr.Zero, IntPtr.Zero);
        }

        // NOTE: if this always return false, close & restart Visual Studio
        // this is probably due to the vshost.exe thing
        public void RunFirstInstance(Action action, IntPtr wParam, IntPtr lParam)
        {
            if (action == null)
                throw new ArgumentNullException("action");

            if (WaitForMutext(wParam, lParam))
            {
                try
                {
                    action();
                }
                finally
                {
                    ReleaseMutex();
                }
            }
        }

        public static void ActivateWindow(IntPtr hwnd)
        {
            if (hwnd == IntPtr.Zero)
                return;

            FormUtilities.ActivateWindow(FormUtilities.GetModalWindow(hwnd));
        }

        public void OnWndProc(IntPtr hwnd, int m, IntPtr wParam, IntPtr lParam, bool restorePlacement, bool activate)
        {
            if (m == Message)
            {
                if (restorePlacement)
                {
                    WindowPlacement placement = WindowPlacement.GetPlacement(hwnd, false);
                    if (placement.IsValid && placement.IsMinimized)
                    {
                        const int SW_SHOWNORMAL = 1;
                        placement.ShowCmd = SW_SHOWNORMAL;
                        placement.SetPlacement(hwnd);
                    }
                }

                if (activate)
                {
                    SetForegroundWindow(hwnd);
                    FormUtilities.ActivateWindow(FormUtilities.GetModalWindow(hwnd));
                }
            }
        }

#if WINFORMS // define this for Winforms apps
        public void OnWndProc(System.Windows.Forms.Form form, int m, IntPtr wParam, IntPtr lParam, bool activate)
        {
            if (form == null)
                throw new ArgumentNullException("form");

            if (m == Message)
            {
                if (activate)
                {
                    if (form.WindowState == System.Windows.Forms.FormWindowState.Minimized)
                    {
                        form.WindowState = System.Windows.Forms.FormWindowState.Normal;
                    }

                    form.Activate();
                    FormUtilities.ActivateWindow(FormUtilities.GetModalWindow(form.Handle));
                }
            }
        }

        public void OnWndProc(System.Windows.Forms.Form form, System.Windows.Forms.Message m, bool activate)
        {
            if (form == null)
                throw new ArgumentNullException("form");

            OnWndProc(form, m.Msg, m.WParam, m.LParam, activate);
        }
#endif

        public void ReleaseMutex()
        {
            Mutex.ReleaseMutex();
        }

        public bool WaitForMutext(bool force, IntPtr wParam, IntPtr lParam)
        {
            bool b = PrivateWaitForMutext(force);
            if (!b)
            {
                PostMessage((IntPtr)HWND_BROADCAST, Message, wParam, lParam);
            }
            return b;
        }

        public bool WaitForMutext(IntPtr wParam, IntPtr lParam)
        {
            return WaitForMutext(false, wParam, lParam);
        }

        private bool PrivateWaitForMutext(bool force)
        {
            if (force)
                return true;

            try
            {
                return Mutex.WaitOne(TimeSpan.Zero, true);
            }
            catch (AbandonedMutexException)
            {
                return true;
            }
        }
    }

    // NOTE: don't add any field or public get/set property, as this must exactly map to Windows' WINDOWPLACEMENT structure
    [StructLayout(LayoutKind.Sequential)]
    public struct WindowPlacement
    {
        public int Length { get; set; }
        public int Flags { get; set; }
        public int ShowCmd { get; set; }
        public int MinPositionX { get; set; }
        public int MinPositionY { get; set; }
        public int MaxPositionX { get; set; }
        public int MaxPositionY { get; set; }
        public int NormalPositionLeft { get; set; }
        public int NormalPositionTop { get; set; }
        public int NormalPositionRight { get; set; }
        public int NormalPositionBottom { get; set; }

        [DllImport("user32.dll", SetLastError = true)]
        private static extern bool SetWindowPlacement(IntPtr hWnd, ref WindowPlacement lpwndpl);

        [DllImport("user32.dll", SetLastError = true)]
        private static extern bool GetWindowPlacement(IntPtr hWnd, ref WindowPlacement lpwndpl);

        private const int SW_SHOWMINIMIZED = 2;

        public bool IsMinimized
        {
            get
            {
                return ShowCmd == SW_SHOWMINIMIZED;
            }
        }

        public bool IsValid
        {
            get
            {
                return Length == Marshal.SizeOf(typeof(WindowPlacement));
            }
        }

        public void SetPlacement(IntPtr windowHandle)
        {
            SetWindowPlacement(windowHandle, ref this);
        }

        public static WindowPlacement GetPlacement(IntPtr windowHandle, bool throwOnError)
        {
            WindowPlacement placement = new WindowPlacement();
            if (windowHandle == IntPtr.Zero)
                return placement;

            placement.Length = Marshal.SizeOf(typeof(WindowPlacement));
            if (!GetWindowPlacement(windowHandle, ref placement))
            {
                if (throwOnError)
                    throw new Win32Exception(Marshal.GetLastWin32Error());

                return new WindowPlacement();
            }
            return placement;
        }
    }

    public static class FormUtilities
    {
        [DllImport("user32.dll")]
        private static extern IntPtr GetWindow(IntPtr hWnd, int uCmd);

        [DllImport("user32.dll", SetLastError = true)]
        private static extern IntPtr SetActiveWindow(IntPtr hWnd);

        [DllImport("user32.dll")]
        private static extern bool IsWindowVisible(IntPtr hWnd);

        [DllImport("kernel32.dll")]
        public static extern int GetCurrentThreadId();

        private delegate bool EnumChildrenCallback(IntPtr hwnd, IntPtr lParam);

        [DllImport("user32.dll")]
        private static extern bool EnumThreadWindows(int dwThreadId, EnumChildrenCallback lpEnumFunc, IntPtr lParam);

        private class ModalWindowUtil
        {
            private const int GW_OWNER = 4;
            private int _maxOwnershipLevel;
            private IntPtr _maxOwnershipHandle;

            private bool EnumChildren(IntPtr hwnd, IntPtr lParam)
            {
                int level = 1;
                if (IsWindowVisible(hwnd) && IsOwned(lParam, hwnd, ref level))
                {
                    if (level > _maxOwnershipLevel)
                    {
                        _maxOwnershipHandle = hwnd;
                        _maxOwnershipLevel = level;
                    }
                }
                return true;
            }

            private static bool IsOwned(IntPtr owner, IntPtr hwnd, ref int level)
            {
                IntPtr o = GetWindow(hwnd, GW_OWNER);
                if (o == IntPtr.Zero)
                    return false;

                if (o == owner)
                    return true;

                level++;
                return IsOwned(owner, o, ref level);
            }

            public static void ActivateWindow(IntPtr hwnd)
            {
                if (hwnd != IntPtr.Zero)
                {
                    SetActiveWindow(hwnd);
                }
            }

            public static IntPtr GetModalWindow(IntPtr owner)
            {
                ModalWindowUtil util = new ModalWindowUtil();
                EnumThreadWindows(GetCurrentThreadId(), util.EnumChildren, owner);
                return util._maxOwnershipHandle; // may be IntPtr.Zero
            }
        }

        public static void ActivateWindow(IntPtr hwnd)
        {
            ModalWindowUtil.ActivateWindow(hwnd);
        }

        public static IntPtr GetModalWindow(IntPtr owner)
        {
            return ModalWindowUtil.GetModalWindow(owner);
        }
    }
}

这段代码应该转到main方法。关于WPF中main方法的更多信息，请参阅这里。

[DllImport("user32.dll")]
private static extern Boolean ShowWindow(IntPtr hWnd, Int32 nCmdShow);

private const int SW_SHOWMAXIMIZED = 3;

static void Main() 
{
    Process currentProcess = Process.GetCurrentProcess();
    var runningProcess = (from process in Process.GetProcesses()
                          where
                            process.Id != currentProcess.Id &&
                            process.ProcessName.Equals(
                              currentProcess.ProcessName,
                              StringComparison.Ordinal)
                          select process).FirstOrDefault();
    if (runningProcess != null)
    {
        ShowWindow(runningProcess.MainWindowHandle, SW_SHOWMAXIMIZED);
       return; 
    }
}

方法2

static void Main()
{
    string procName = Process.GetCurrentProcess().ProcessName;
    // get the list of all processes by that name

    Process[] processes=Process.GetProcessesByName(procName);

    if (processes.Length > 1)
    {
        MessageBox.Show(procName + " already running");  
        return;
    } 
    else
    {
        // Application.Run(...);
    }
}

注意:上述方法假设您的进程/应用程序有唯一的名称。因为它使用进程名来查找是否有现有的处理器。所以，如果你的应用程序有一个非常普通的名字(如:记事本)，上述方法是行不通的。