我喜欢一个解决方案，以允许多个实例，如果exe是从其他路径调用。我修改了CharithJ溶液方法一:

   static class Program {
    [DllImport("user32.dll")]
    private static extern bool ShowWindow(IntPtr hWnd, Int32 nCmdShow);
    [DllImport("User32.dll")]
    public static extern Int32 SetForegroundWindow(IntPtr hWnd);
    [STAThread]
    static void Main() {
        Process currentProcess = Process.GetCurrentProcess();
        foreach (var process in Process.GetProcesses()) {
            try {
                if ((process.Id != currentProcess.Id) && 
                    (process.ProcessName == currentProcess.ProcessName) &&
                    (process.MainModule.FileName == currentProcess.MainModule.FileName)) {
                    ShowWindow(process.MainWindowHandle, 5); // const int SW_SHOW = 5; //Activates the window and displays it in its current size and position. 
                    SetForegroundWindow(process.MainWindowHandle);
                    return;
                }
            } catch (Exception ex) {
                //ignore Exception "Access denied "
            }
        }

        Application.EnableVisualStyles();
        Application.SetCompatibleTextRenderingDefault(false);
        Application.Run(new Form1());
    }
}

从这里。

跨进程互斥锁的一个常见用途是确保一个程序一次只能运行一个实例。以下是如何做到的:

class OneAtATimePlease {

  // Use a name unique to the application (eg include your company URL)
  static Mutex mutex = new Mutex (false, "oreilly.com OneAtATimeDemo");

  static void Main()
  {
    // Wait 5 seconds if contended – in case another instance
    // of the program is in the process of shutting down.
    if (!mutex.WaitOne(TimeSpan.FromSeconds (5), false))
    {
        Console.WriteLine("Another instance of the app is running. Bye!");
        return;
    }

    try
    {    
        Console.WriteLine("Running - press Enter to exit");
        Console.ReadLine();
    }
    finally
    {
        mutex.ReleaseMutex();
    }    
  }    
}

互斥锁的一个很好的特性是，如果应用程序在没有首先调用ReleaseMutex的情况下终止，CLR将自动释放互斥锁。

使用互斥量解决方案:

using System;
using System.Windows.Forms;
using System.Threading;

namespace OneAndOnlyOne
{
static class Program
{
    static String _mutexID = " // generate guid"
    /// <summary>
    /// The main entry point for the application.
    /// </summary>
    [STAThread]
    static void Main()
    {
        Application.EnableVisualStyles();
        Application.SetCompatibleTextRenderingDefault(false);

        Boolean _isNotRunning;
        using (Mutex _mutex = new Mutex(true, _mutexID, out _isNotRunning))
        {
            if (_isNotRunning)
            {
                Application.Run(new Form1());
            }
            else
            {
                MessageBox.Show("An instance is already running.");
                return;
            }
        }
    }
}
}

基于命名互斥的方法不是跨平台的，因为命名互斥在Mono中不是全局的。基于进程枚举的方法没有任何同步，可能会导致不正确的行为(例如，同时启动的多个进程可能都根据时间自行终止)。在控制台应用程序中不需要基于windows系统的方法。这个解决方案建立在Divin的答案之上，解决了所有这些问题:

using System;
using System.IO;

namespace TestCs
{
    public class Program
    {
        // The app id must be unique. Generate a new guid for your application. 
        public static string AppId = "01234567-89ab-cdef-0123-456789abcdef";

        // The stream is stored globally to ensure that it won't be disposed before the application terminates.
        public static FileStream UniqueInstanceStream;

        public static int Main(string[] args)
        {
            EnsureUniqueInstance();

            // Your code here.

            return 0;
        }

        private static void EnsureUniqueInstance()
        {
            // Note: If you want the check to be per-user, use Environment.SpecialFolder.ApplicationData instead.
            string lockDir = Path.Combine(
                Environment.GetFolderPath(Environment.SpecialFolder.CommonApplicationData),
                "UniqueInstanceApps");
            string lockPath = Path.Combine(lockDir, $"{AppId}.unique");

            Directory.CreateDirectory(lockDir);

            try
            {
                // Create the file with exclusive write access. If this fails, then another process is executing.
                UniqueInstanceStream = File.Open(lockPath, FileMode.Create, FileAccess.Write, FileShare.None);

                // Although only the line above should be sufficient, when debugging with a vshost on Visual Studio
                // (that acts as a proxy), the IO exception isn't passed to the application before a Write is executed.
                UniqueInstanceStream.Write(new byte[] { 0 }, 0, 1);
                UniqueInstanceStream.Flush();
            }
            catch
            {
                throw new Exception("Another instance of the application is already running.");
            }
        }
    }
}

我最喜欢的解决方案来自MVP丹尼尔·沃恩: 强制执行单实例Wpf应用程序

它使用MemoryMappedFile将命令行参数发送给第一个实例:

/// <summary>
/// This class allows restricting the number of executables in execution, to one.
/// </summary>
public sealed class SingletonApplicationEnforcer
{
    readonly Action<IEnumerable<string>> processArgsFunc;
    readonly string applicationId;
    Thread thread;
    string argDelimiter = "_;;_";

    /// <summary>
    /// Gets or sets the string that is used to join 
    /// the string array of arguments in memory.
    /// </summary>
    /// <value>The arg delimeter.</value>
    public string ArgDelimeter
    {
        get
        {
            return argDelimiter;
        }
        set
        {
            argDelimiter = value;
        }
    }

    /// <summary>
    /// Initializes a new instance of the <see cref="SingletonApplicationEnforcer"/> class.
    /// </summary>
    /// <param name="processArgsFunc">A handler for processing command line args 
    /// when they are received from another application instance.</param>
    /// <param name="applicationId">The application id used 
    /// for naming the <seealso cref="EventWaitHandle"/>.</param>
    public SingletonApplicationEnforcer(Action<IEnumerable<string>> processArgsFunc, 
        string applicationId = "DisciplesRock")
    {
        if (processArgsFunc == null)
        {
            throw new ArgumentNullException("processArgsFunc");
        }
        this.processArgsFunc = processArgsFunc;
        this.applicationId = applicationId;
    }

    /// <summary>
    /// Determines if this application instance is not the singleton instance.
    /// If this application is not the singleton, then it should exit.
    /// </summary>
    /// <returns><c>true</c> if the application should shutdown, 
    /// otherwise <c>false</c>.</returns>
    public bool ShouldApplicationExit()
    {
        bool createdNew;
        string argsWaitHandleName = "ArgsWaitHandle_" + applicationId;
        string memoryFileName = "ArgFile_" + applicationId;

        EventWaitHandle argsWaitHandle = new EventWaitHandle(
            false, EventResetMode.AutoReset, argsWaitHandleName, out createdNew);

        GC.KeepAlive(argsWaitHandle);

        if (createdNew)
        {
            /* This is the main, or singleton application. 
                * A thread is created to service the MemoryMappedFile. 
                * We repeatedly examine this file each time the argsWaitHandle 
                * is Set by a non-singleton application instance. */
            thread = new Thread(() =>
                {
                    try
                    {
                        using (MemoryMappedFile file = MemoryMappedFile.CreateOrOpen(memoryFileName, 10000))
                        {
                            while (true)
                            {
                                argsWaitHandle.WaitOne();
                                using (MemoryMappedViewStream stream = file.CreateViewStream())
                                {
                                    var reader = new BinaryReader(stream);
                                    string args;
                                    try
                                    {
                                        args = reader.ReadString();
                                    }
                                    catch (Exception ex)
                                    {
                                        Debug.WriteLine("Unable to retrieve string. " + ex);
                                        continue;
                                    }
                                    string[] argsSplit = args.Split(new string[] { argDelimiter }, 
                                                                    StringSplitOptions.RemoveEmptyEntries);
                                    processArgsFunc(argsSplit);
                                }

                            }
                        }
                    }
                    catch (Exception ex)
                    {
                        Debug.WriteLine("Unable to monitor memory file. " + ex);
                    }
                });

            thread.IsBackground = true;
            thread.Start();
        }
        else
        {
            /* Non singleton application instance. 
                * Should exit, after passing command line args to singleton process, 
                * via the MemoryMappedFile. */
            using (MemoryMappedFile mmf = MemoryMappedFile.OpenExisting(memoryFileName))
            {
                using (MemoryMappedViewStream stream = mmf.CreateViewStream())
                {
                    var writer = new BinaryWriter(stream);
                    string[] args = Environment.GetCommandLineArgs();
                    string joined = string.Join(argDelimiter, args);
                    writer.Write(joined);
                }
            }
            argsWaitHandle.Set();
        }

        return !createdNew;
    }
}

我添加了一个sendMessage方法到NativeMethods类。

显然，如果应用程序没有显示在任务栏中，postmessage方法不会工作，但是使用sendmessage方法解决了这个问题。

class NativeMethods
{
    public const int HWND_BROADCAST = 0xffff;
    public static readonly int WM_SHOWME = RegisterWindowMessage("WM_SHOWME");
    [DllImport("user32")]
    public static extern bool PostMessage(IntPtr hwnd, int msg, IntPtr wparam, IntPtr lparam);
    [DllImport("user32.dll", CharSet = CharSet.Auto)]
    public static extern IntPtr SendMessage(IntPtr hWnd, int Msg, IntPtr wParam, IntPtr lParam);
    [DllImport("user32")]
    public static extern int RegisterWindowMessage(string message);
}