这是用.NET 5/Core来实现的一种很好很短的方法

private void textBox1_KeyDown(object sender, KeyEventArgs e) {
  if (e.KeyData != Keys.Back)
    e.SuppressKeyPress = !int.TryParse(Convert.ToString((char) e.KeyData), out int _);
}

编辑:增加了退格键的支持

我在CodePlex上做了一些东西。

它通过拦截TextChanged事件来工作。如果结果是一个好的数字，它将被存储。如果是错误的，最后的好值将恢复。源代码有点太大，不适合在这里发布，但这里有一个指向处理此逻辑核心的类的链接。

不要忘记用户可以在文本框中粘贴无效文本。

如果你想限制它，遵循下面的代码:

private void ultraTextEditor1_TextChanged(object sender, EventArgs e)
{
    string append="";
    foreach (char c in ultraTextEditor1.Text)
    {
        if ((!Char.IsNumber(c)) && (c != Convert.ToChar(Keys.Back)))
        {

        }
        else
        {
            append += c;
        }
    }

    ultraTextEditor1.Text = append;
}   

这可能有用。它允许“真实”数值，包括正确的小数点和前面的加号或减号。从相关的KeyPress事件中调用它。

       private bool IsOKForDecimalTextBox(char theCharacter, TextBox theTextBox)
    {
        // Only allow control characters, digits, plus and minus signs.
        // Only allow ONE plus sign.
        // Only allow ONE minus sign.
        // Only allow the plus or minus sign as the FIRST character.
        // Only allow ONE decimal point.
        // Do NOT allow decimal point or digits BEFORE any plus or minus sign.

        if (
            !char.IsControl(theCharacter)
            && !char.IsDigit(theCharacter)
            && (theCharacter != '.')
            && (theCharacter != '-')
            && (theCharacter != '+')
        )
        {
            // Then it is NOT a character we want allowed in the text box.
            return false;
        }



        // Only allow one decimal point.
        if (theCharacter == '.'
            && theTextBox.Text.IndexOf('.') > -1)
        {
            // Then there is already a decimal point in the text box.
            return false;
        }

        // Only allow one minus sign.
        if (theCharacter == '-'
            && theTextBox.Text.IndexOf('-') > -1)
        {
            // Then there is already a minus sign in the text box.
            return false;
        }

        // Only allow one plus sign.
        if (theCharacter == '+'
            && theTextBox.Text.IndexOf('+') > -1)
        {
            // Then there is already a plus sign in the text box.
            return false;
        }

        // Only allow one plus sign OR minus sign, but not both.
        if (
            (
                (theCharacter == '-')
                || (theCharacter == '+')
            )
            && 
            (
                (theTextBox.Text.IndexOf('-') > -1)
                ||
                (theTextBox.Text.IndexOf('+') > -1)
            )
            )
        {
            // Then the user is trying to enter a plus or minus sign and
            // there is ALREADY a plus or minus sign in the text box.
            return false;
        }

        // Only allow a minus or plus sign at the first character position.
        if (
            (
                (theCharacter == '-')
                || (theCharacter == '+')
            )
            && theTextBox.SelectionStart != 0
            )
        {
            // Then the user is trying to enter a minus or plus sign at some position 
            // OTHER than the first character position in the text box.
            return false;
        }

        // Only allow digits and decimal point AFTER any existing plus or minus sign
        if  (
                (
                    // Is digit or decimal point
                    char.IsDigit(theCharacter)
                    ||
                    (theCharacter == '.')
                )
                &&
                (
                    // A plus or minus sign EXISTS
                    (theTextBox.Text.IndexOf('-') > -1)
                    ||
                    (theTextBox.Text.IndexOf('+') > -1)
                )
                &&
                    // Attempting to put the character at the beginning of the field.
                    theTextBox.SelectionStart == 0
            )
        {
            // Then the user is trying to enter a digit or decimal point in front of a minus or plus sign.
            return false;
        }

        // Otherwise the character is perfectly fine for a decimal value and the character
        // may indeed be placed at the current insertion position.
        return true;
    }

整数和浮点数都需要被接受，包括负数。

private void textBox1_KeyPress(object sender, KeyPressEventArgs e)
{
    // Text
    string text = ((Control) sender).Text;

    // Is Negative Number?
    if (e.KeyChar == '-' && text.Length == 0)
    {
        e.Handled = false;
        return;
    }

    // Is Float Number?
    if (e.KeyChar == '.' && text.Length > 0 && !text.Contains("."))
    {
        e.Handled = false;
        return;
    }

    // Is Digit?
    e.Handled = (!char.IsDigit(e.KeyChar) && !char.IsControl(e.KeyChar));
}

看一下WinForm中的输入处理

我已经发布了我的解决方案，在文本框上使用ProcessCmdKey和OnKeyPress事件。注释向您展示了如何使用Regex来验证键按和适当地阻止/允许。