这可能比马克的清单理解还要快:

list(itertools.filterfalse(set(temp2).__contains__, temp1))

由于目前的解决方案都不产生一个元组，我将抛出:

temp3 = tuple(set(temp1) - set(temp2))

另外:

#edited using @Mark Byers idea. If you accept this one as answer, just accept his instead.
temp3 = tuple(x for x in temp1 if x not in set(temp2))

像其他在这个方向上得到答案的非元组一样，它保持了顺序

这可以用一行来解决。 问题给出两个列表(temp1和temp2)，在第三个列表(temp3)中返回它们的差值。

temp3 = list(set(temp1).difference(set(temp2)))

如果您想要更类似于变更集的东西……可以使用Counter

from collections import Counter

def diff(a, b):
  """ more verbose than needs to be, for clarity """
  ca, cb = Counter(a), Counter(b)
  to_add = cb - ca
  to_remove = ca - cb
  changes = Counter(to_add)
  changes.subtract(to_remove)
  return changes

lista = ['one', 'three', 'four', 'four', 'one']
listb = ['one', 'two', 'three']

In [127]: diff(lista, listb)
Out[127]: Counter({'two': 1, 'one': -1, 'four': -2})
# in order to go from lista to list b, you need to add a "two", remove a "one", and remove two "four"s

In [128]: diff(listb, lista)
Out[128]: Counter({'four': 2, 'one': 1, 'two': -1})
# in order to go from listb to lista, you must add two "four"s, add a "one", and remove a "two"

假设我们有两个列表

list1 = [1, 3, 5, 7, 9]
list2 = [1, 2, 3, 4, 5]

从上面两个列表中我们可以看到，list2中有第1、3、5项，而第7、9项不存在。另一方面，第1、3、5项在list1中存在，第2、4项不存在。

返回包含项目7,9和2,4的新列表的最佳解决方案是什么?

以上所有答案都找到了解，现在什么是最优的?

def difference(list1, list2):
    new_list = []
    for i in list1:
        if i not in list2:
            new_list.append(i)

    for j in list2:
        if j not in list1:
            new_list.append(j)
    return new_list

与

def sym_diff(list1, list2):
    return list(set(list1).symmetric_difference(set(list2)))

利用时间，我们可以看到结果

t1 = timeit.Timer("difference(list1, list2)", "from __main__ import difference, 
list1, list2")
t2 = timeit.Timer("sym_diff(list1, list2)", "from __main__ import sym_diff, 
list1, list2")

print('Using two for loops', t1.timeit(number=100000), 'Milliseconds')
print('Using two for loops', t2.timeit(number=100000), 'Milliseconds')

返回

[7, 9, 2, 4]
Using two for loops 0.11572412995155901 Milliseconds
Using symmetric_difference 0.11285737506113946 Milliseconds

Process finished with exit code 0

这可能比马克的清单理解还要快:

list(itertools.filterfalse(set(temp2).__contains__, temp1))