The best way is deltaE. DeltaE is a number that shows the difference of the colors. If deltae < 1 then the difference can't recognize by human eyes. I wrote a code in canvas and js for converting rgb to lab and then calculating delta e. On this example the code is recognising pixels which have different color with a base color that I saved as LAB1. and then if it is different makes those pixels red. You can increase or reduce the sensitivity of the color difference with increae or decrease the acceptable range of delta e. In this example I assigned 10 for deltaE in the line that I wrote (deltae <= 10):

<script>   
  var constants = {
    canvasWidth: 700, // In pixels.
    canvasHeight: 600, // In pixels.
    colorMap: new Array() 
          };



  // -----------------------------------------------------------------------------------------------------

  function fillcolormap(imageObj1) {


    function rgbtoxyz(red1,green1,blue1){ // a converter for converting rgb model to xyz model
 var red2 = red1/255;
 var green2 = green1/255;
 var blue2 = blue1/255;
 if(red2>0.04045){
      red2 = (red2+0.055)/1.055;
      red2 = Math.pow(red2,2.4);
 }
 else{
      red2 = red2/12.92;
 }
 if(green2>0.04045){
      green2 = (green2+0.055)/1.055;
      green2 = Math.pow(green2,2.4);    
 }
 else{
      green2 = green2/12.92;
 }
 if(blue2>0.04045){
      blue2 = (blue2+0.055)/1.055;
      blue2 = Math.pow(blue2,2.4);    
 }
 else{
      blue2 = blue2/12.92;
 }
 red2 = (red2*100);
 green2 = (green2*100);
 blue2 = (blue2*100);
 var x = (red2 * 0.4124) + (green2 * 0.3576) + (blue2 * 0.1805);
 var y = (red2 * 0.2126) + (green2 * 0.7152) + (blue2 * 0.0722);
 var z = (red2 * 0.0193) + (green2 * 0.1192) + (blue2 * 0.9505);
 var xyzresult = new Array();
 xyzresult[0] = x;
 xyzresult[1] = y;
 xyzresult[2] = z;
 return(xyzresult);
} //end of rgb_to_xyz function
function xyztolab(xyz){ //a convertor from xyz to lab model
 var x = xyz[0];
 var y = xyz[1];
 var z = xyz[2];
 var x2 = x/95.047;
 var y2 = y/100;
 var z2 = z/108.883;
 if(x2>0.008856){
      x2 = Math.pow(x2,1/3);
 }
 else{
      x2 = (7.787*x2) + (16/116);
 }
 if(y2>0.008856){
      y2 = Math.pow(y2,1/3);
 }
 else{
      y2 = (7.787*y2) + (16/116);
 }
 if(z2>0.008856){
      z2 = Math.pow(z2,1/3);
 }
 else{
      z2 = (7.787*z2) + (16/116);
 }
 var l= 116*y2 - 16;
 var a= 500*(x2-y2);
 var b= 200*(y2-z2);
 var labresult = new Array();
 labresult[0] = l;
 labresult[1] = a;
 labresult[2] = b;
 return(labresult);

}

    var canvas = document.getElementById('myCanvas');
    var context = canvas.getContext('2d');
    var imageX = 0;
    var imageY = 0;

    context.drawImage(imageObj1, imageX, imageY, 240, 140);
    var imageData = context.getImageData(0, 0, 240, 140);
    var data = imageData.data;
    var n = data.length;
   // iterate over all pixels

    var m = 0;
    for (var i = 0; i < n; i += 4) {
      var red = data[i];
      var green = data[i + 1];
      var blue = data[i + 2];
    var xyzcolor = new Array();
    xyzcolor = rgbtoxyz(red,green,blue);
    var lab = new Array();
    lab = xyztolab(xyzcolor);
    constants.colorMap.push(lab); //fill up the colormap array with lab colors.         
      } 

  }

// -----------------------------------------------------------------------------------------------------

    function colorize(pixqty) {

         function deltae94(lab1,lab2){    //calculating Delta E 1994

         var c1 = Math.sqrt((lab1[1]*lab1[1])+(lab1[2]*lab1[2]));
         var c2 =  Math.sqrt((lab2[1]*lab2[1])+(lab2[2]*lab2[2]));
         var dc = c1-c2;
         var dl = lab1[0]-lab2[0];
         var da = lab1[1]-lab2[1];
         var db = lab1[2]-lab2[2];
         var dh = Math.sqrt((da*da)+(db*db)-(dc*dc));
         var first = dl;
         var second = dc/(1+(0.045*c1));
         var third = dh/(1+(0.015*c1));
         var deresult = Math.sqrt((first*first)+(second*second)+(third*third));
         return(deresult);
          } // end of deltae94 function
    var lab11 =  new Array("80","-4","21");
    var lab12 = new Array();
    var k2=0;
    var canvas = document.getElementById('myCanvas');
                                        var context = canvas.getContext('2d');
                                        var imageData = context.getImageData(0, 0, 240, 140);
                                        var data = imageData.data;

    for (var i=0; i<pixqty; i++) {

    lab12 = constants.colorMap[i];

    var deltae = deltae94(lab11,lab12);     
                                        if (deltae <= 10) {

                                        data[i*4] = 255;
                                        data[(i*4)+1] = 0;
                                        data[(i*4)+2] = 0;  
                                        k2++;
                                        } // end of if 
                                } //end of for loop
    context.clearRect(0,0,240,140);
    alert(k2);
    context.putImageData(imageData,0,0);
} 
// -----------------------------------------------------------------------------------------------------

$(window).load(function () {    
  var imageObj = new Image();
  imageObj.onload = function() {
  fillcolormap(imageObj);    
  }
  imageObj.src = './mixcolor.png';
});

// ---------------------------------------------------------------------------------------------------
 var pixno2 = 240*140; 
 </script>

Actually I walked the same path a couple of months ago. There is no perfect answer to the question (that was asked here a couple of times) but there is one, more sophisticated than the sqrt(r-r) etc. answer and more easy to implement directly with RGB without moving to all kinds of alternate color spaces. I found this formula here which is a low cost approximation of the quite complicated real formula (by the CIE which is the W3C of colors, since this is a not finished quest, you can find older and simpler color difference equations there). Good Luck.

编辑:为了子孙后代，这里是相关的C代码:

typedef struct {
     unsigned char r, g, b;
} RGB;

double ColourDistance(RGB e1, RGB e2)
{
    long rmean = ( (long)e1.r + (long)e2.r ) / 2;
    long r = (long)e1.r - (long)e2.r;
    long g = (long)e1.g - (long)e2.g;
    long b = (long)e1.b - (long)e2.b;
    return sqrt((((512+rmean)*r*r)>>8) + 4*g*g + (((767-rmean)*b*b)>>8));
}

我尝试了各种方法，如LAB颜色空间，HSV比较，我发现光度在这个目的上非常有效。

这是Python版本

def lum(c):
    def factor(component):
        component = component / 255;
        if (component <= 0.03928):
            component = component / 12.92;
        else:
            component = math.pow(((component + 0.055) / 1.055), 2.4);

        return component
    components = [factor(ci) for ci in c]

    return (components[0] * 0.2126 + components[1] * 0.7152 + components[2] * 0.0722) + 0.05;

def color_distance(c1, c2):

    l1 = lum(c1)
    l2 = lum(c2)
    higher = max(l1, l2)
    lower = min(l1, l2)

    return (higher - lower) / higher


c1 = ImageColor.getrgb('white')
c2 = ImageColor.getrgb('yellow')
print(color_distance(c1, c2))

会给你

0.0687619047619048

我猜你最后想分析一幅完整的图像，对吧?所以你可以检查单位颜色矩阵的最小/最大差值。

大多数处理图形的数学操作都使用矩阵，因为使用矩阵的可能算法通常比经典的逐点距离和比较计算更快。(例如，对于使用DirectX, OpenGL，…的操作)

所以我认为你应该从这里开始:

http://en.wikipedia.org/wiki/Identity_matrix

http://en.wikipedia.org/wiki/Matrix_difference_equation

…正如Beska在上面评论的那样:

这可能不会带来最好的“可见”差异……

这也意味着，如果你在处理图像，你的算法取决于你对“相似”的定义。

颜色值有不止一个维度，所以没有内在的方法来比较两种颜色。您必须为您的用例确定颜色的含义，从而确定如何最好地比较它们。

很可能你想比较颜色的色相、饱和度和/或明度属性，而不是红/绿/蓝组件。如果你不知道如何比较它们，那就拿几对样品颜色，在心里比较一下，然后试着向自己证明/解释为什么它们相似/不同。

一旦你知道了你想要比较的颜色的哪些属性/成分，那么你就需要弄清楚如何从颜色中提取这些信息。

最有可能的是，你只需要将颜色从常见的RedGreenBlue表示转换为HueSaturationLightness，然后计算类似的东西

avghue = (color1.hue + color2.hue)/2
distance = abs(color1.hue-avghue)

这个例子会给你一个简单的标量值，指示颜色的渐变/色相彼此之间的距离。

参见维基百科上的HSL和HSV。

快速回答

我找到这个帖子是因为我需要这个问题的Swift版本。由于还没有人给出答案，我的答案是:

extension UIColor {

    var rgba: (red: CGFloat, green: CGFloat, blue: CGFloat, alpha: CGFloat) {
        var red: CGFloat = 0
        var green: CGFloat = 0
        var blue: CGFloat = 0
        var alpha: CGFloat = 0
        getRed(&red, green: &green, blue: &blue, alpha: &alpha)

        return (red, green, blue, alpha)
    }

    func isSimilar(to colorB: UIColor) -> Bool {
        let rgbA = self.rgba
        let rgbB = colorB.rgba

        let diffRed = abs(CGFloat(rgbA.red) - CGFloat(rgbB.red))
        let diffGreen = abs(rgbA.green - rgbB.green)
        let diffBlue = abs(rgbA.blue - rgbB.blue)

        let pctRed = diffRed
        let pctGreen = diffGreen
        let pctBlue = diffBlue

        let pct = (pctRed + pctGreen + pctBlue) / 3 * 100

        return pct < 10 ? true : false
    }
}

用法:

let black: UIColor = UIColor.black
let white: UIColor = UIColor.white

let similar: Bool = black.isSimilar(to: white)

我设置小于10%的差异返回相似的颜色，但你可以自定义这自己。