正如您在Tim Golden的文章(由Horst Gutmann指出)中看到的，WIN32相对复杂，它监视目录，而不是单个文件。

我建议你研究一下IronPython，它是一个。net python实现。 在IronPython中，你可以使用所有的。net功能——包括

System.IO.FileSystemWatcher

它用一个简单的Event接口处理单个文件。

我不知道任何Windows特有的函数。您可以尝试每秒钟/分钟/小时获取文件的MD5哈希值(取决于您需要它的速度)，并将其与最后的哈希值进行比较。当它不同时，您知道文件已被更改，并读取最新的行。

对我来说，最简单的解决方法就是使用看门狗的工具watchmedo

从https://pypi.python.org/pypi/watchdog我现在有一个进程，在一个目录中查找sql文件，并在必要时执行它们。

watchmedo shell-command \
--patterns="*.sql" \
--recursive \
--command='~/Desktop/load_files_into_mysql_database.sh' \
.

ACTIONS = {
  1 : "Created",
  2 : "Deleted",
  3 : "Updated",
  4 : "Renamed from something",
  5 : "Renamed to something"
}
FILE_LIST_DIRECTORY = 0x0001

class myThread (threading.Thread):
    def __init__(self, threadID, fileName, directory, origin):
        threading.Thread.__init__(self)
        self.threadID = threadID
        self.fileName = fileName
        self.daemon = True
        self.dir = directory
        self.originalFile = origin
    def run(self):
        startMonitor(self.fileName, self.dir, self.originalFile)

def startMonitor(fileMonitoring,dirPath,originalFile):
    hDir = win32file.CreateFile (
        dirPath,
        FILE_LIST_DIRECTORY,
        win32con.FILE_SHARE_READ | win32con.FILE_SHARE_WRITE,
        None,
        win32con.OPEN_EXISTING,
        win32con.FILE_FLAG_BACKUP_SEMANTICS,
        None
    )
    # Wait for new data and call ProcessNewData for each new chunk that's
    # written
    while 1:
        # Wait for a change to occur
        results = win32file.ReadDirectoryChangesW (
            hDir,
            1024,
            False,
            win32con.FILE_NOTIFY_CHANGE_LAST_WRITE,
            None,
            None
        )
        # For each change, check to see if it's updating the file we're
        # interested in
        for action, file_M in results:
            full_filename = os.path.join (dirPath, file_M)
            #print file, ACTIONS.get (action, "Unknown")
            if len(full_filename) == len(fileMonitoring) and action == 3:
                #copy to main file
                ...

我会尝试这样的方法。

    try:
            f = open(filePath)
    except IOError:
            print "No such file: %s" % filePath
            raw_input("Press Enter to close window")
    try:
            lines = f.readlines()
            while True:
                    line = f.readline()
                    try:
                            if not line:
                                    time.sleep(1)
                            else:
                                    functionThatAnalisesTheLine(line)
                    except Exception, e:
                            # handle the exception somehow (for example, log the trace) and raise the same exception again
                            raw_input("Press Enter to close window")
                            raise e
    finally:
            f.close()

循环检查自上次读取文件以来是否有新的行——如果有，则将其读取并传递给functionThatAnalisesTheLine函数。如果不是，脚本等待1秒并重试该进程。

最简单的解决方案是在间隔之后获取同一个文件的两个实例并进行比较。你可以试试这样的东西

    while True:
        # Capturing the two instances models.py after certain interval of time
        print("Looking for changes in " + app_name.capitalize() + " models.py\nPress 'CTRL + C' to stop the program")
        with open(app_name.capitalize() + '/filename', 'r+') as app_models_file:
            filename_content = app_models_file.read()
        time.sleep(5)
        with open(app_name.capitalize() + '/filename', 'r+') as app_models_file_1:
            filename_content_1 = app_models_file_1.read()
        # Comparing models.py after certain interval of time
        if filename_content == filename_content_1:
            pass
        else:
            print("You made a change in " + app_name.capitalize() + " filename.\n")
            cmd = str(input("Do something with the file?(y/n):"))
            if cmd == 'y':
                # Do Something
            elif cmd == 'n':
                # pass or do something
            else:
                print("Invalid input")