我不知道任何Windows特有的函数。您可以尝试每秒钟/分钟/小时获取文件的MD5哈希值(取决于您需要它的速度)，并将其与最后的哈希值进行比较。当它不同时，您知道文件已被更改，并读取最新的行。

最简单的解决方案是在间隔之后获取同一个文件的两个实例并进行比较。你可以试试这样的东西

    while True:
        # Capturing the two instances models.py after certain interval of time
        print("Looking for changes in " + app_name.capitalize() + " models.py\nPress 'CTRL + C' to stop the program")
        with open(app_name.capitalize() + '/filename', 'r+') as app_models_file:
            filename_content = app_models_file.read()
        time.sleep(5)
        with open(app_name.capitalize() + '/filename', 'r+') as app_models_file_1:
            filename_content_1 = app_models_file_1.read()
        # Comparing models.py after certain interval of time
        if filename_content == filename_content_1:
            pass
        else:
            print("You made a change in " + app_name.capitalize() + " filename.\n")
            cmd = str(input("Do something with the file?(y/n):"))
            if cmd == 'y':
                # Do Something
            elif cmd == 'n':
                # pass or do something
            else:
                print("Invalid input")

因为我已经全局安装了它，所以我最喜欢的方法是使用nodemon。如果你的源代码在src中，你的入口点是src/app.py，那么就像这样简单:

nodemon -w 'src/**' -e py,html --exec python src/app.py

．.． 其中-e py,html允许您控制要监视更改的文件类型。

你试过用看门狗吗?

Python API库和shell实用程序来监视文件系统事件。 目录监视变得很容易 一个跨平台的API。 一个shell工具，用于在目录更改时运行命令。 用一个简单的例子开始快速入门…

下面是一个示例，用于观察每秒写入不超过一行但通常要少得多的输入文件。目标是将最后一行(最近的写入)追加到指定的输出文件。我从我的一个项目中复制了这个，只是删除了所有不相关的行。你必须填写或修改缺失的符号。

from PyQt5.QtCore import QFileSystemWatcher, QSettings, QThread
from ui_main_window import Ui_MainWindow   # Qt Creator gen'd 

class MainWindow(QMainWindow, Ui_MainWindow):
    def __init__(self, parent=None):
        QMainWindow.__init__(self, parent)
        Ui_MainWindow.__init__(self)
        self._fileWatcher = QFileSystemWatcher()
        self._fileWatcher.fileChanged.connect(self.fileChanged)

    def fileChanged(self, filepath):
        QThread.msleep(300)    # Reqd on some machines, give chance for write to complete
        # ^^ About to test this, may need more sophisticated solution
        with open(filepath) as file:
            lastLine = list(file)[-1]
        destPath = self._filemap[filepath]['dest file']
        with open(destPath, 'a') as out_file:               # a= append
            out_file.writelines([lastLine])

当然，并不是严格要求包含QMainWindow类。您可以单独使用QFileSystemWatcher。

为了用轮询和最小依赖来观察单个文件，下面是一个完整的例子，基于Deestan的回答(上面):

import os
import sys 
import time

class Watcher(object):
    running = True
    refresh_delay_secs = 1

    # Constructor
    def __init__(self, watch_file, call_func_on_change=None, *args, **kwargs):
        self._cached_stamp = 0
        self.filename = watch_file
        self.call_func_on_change = call_func_on_change
        self.args = args
        self.kwargs = kwargs

    # Look for changes
    def look(self):
        stamp = os.stat(self.filename).st_mtime
        if stamp != self._cached_stamp:
            self._cached_stamp = stamp
            # File has changed, so do something...
            print('File changed')
            if self.call_func_on_change is not None:
                self.call_func_on_change(*self.args, **self.kwargs)

    # Keep watching in a loop        
    def watch(self):
        while self.running: 
            try: 
                # Look for changes
                time.sleep(self.refresh_delay_secs) 
                self.look() 
            except KeyboardInterrupt: 
                print('\nDone') 
                break 
            except FileNotFoundError:
                # Action on file not found
                pass
            except: 
                print('Unhandled error: %s' % sys.exc_info()[0])

# Call this function each time a change happens
def custom_action(text):
    print(text)

watch_file = 'my_file.txt'

# watcher = Watcher(watch_file)  # simple
watcher = Watcher(watch_file, custom_action, text='yes, changed')  # also call custom action function
watcher.watch()  # start the watch going