这两种方法都有效：

  Uri final = new Uri(Regex.Replace(baseUrl + "/" + relativePath, "(?<!http:)/{2,}", "/"));

Or

  Uri final =new Uri(string.Format("{0}/{1}", baseUrl.ToString().TrimEnd('/'), relativePath.ToString().TrimStart('/')));

即，如果

baseUrl = "http://tesrurl.test.com/Int18"

and

relativePath = "To_Folder"

output = http://tesrurl.test.com/Int18/To_Folder

以下代码将出现一些错误：

 // If you use the below code, some issues will be there in the final URI
 Uri final = new Uri(baseUrl, relativePath);

我必须指出，Path.Combine似乎也能直接实现这一点，至少在.NET 4上是如此。

我结合了前面的所有答案：

    public static string UrlPathCombine(string path1, string path2)
    {
        path1 = path1.TrimEnd('/') + "/";
        path2 = path2.TrimStart('/');

        return Path.Combine(path1, path2)
            .Replace(Path.DirectorySeparatorChar, Path.AltDirectorySeparatorChar);
    }

    [TestMethod]
    public void TestUrl()
    {
        const string P1 = "http://msdn.microsoft.com/slash/library//";
        Assert.AreEqual("http://msdn.microsoft.com/slash/library/site.aspx", UrlPathCombine(P1, "//site.aspx"));

        var path = UrlPathCombine("Http://MyUrl.com/", "Images/Image.jpg");

        Assert.AreEqual(
            "Http://MyUrl.com/Images/Image.jpg",
            path);
    }

这是Microsoft的（OfficeDev PnP）方法UrlUtility。组合：

    const char PATH_DELIMITER = '/';

    /// <summary>
    /// Combines a path and a relative path.
    /// </summary>
    /// <param name="path"></param>
    /// <param name="relative"></param>
    /// <returns></returns>
    public static string Combine(string path, string relative) 
    {
        if(relative == null)
            relative = String.Empty;

        if(path == null)
            path = String.Empty;

        if(relative.Length == 0 && path.Length == 0)
            return String.Empty;

        if(relative.Length == 0)
            return path;

        if(path.Length == 0)
            return relative;

        path = path.Replace('\\', PATH_DELIMITER);
        relative = relative.Replace('\\', PATH_DELIMITER);

        return path.TrimEnd(PATH_DELIMITER) + PATH_DELIMITER + relative.TrimStart(PATH_DELIMITER);
    }

来源：GitHub

Use:

    private Uri UriCombine(string path1, string path2, string path3 = "", string path4 = "")
    {
        string path = System.IO.Path.Combine(path1, path2.TrimStart('\\', '/'), path3.TrimStart('\\', '/'), path4.TrimStart('\\', '/'));
        string url = path.Replace('\\','/');
        return new Uri(url);
    }

它的好处是行为与Path.Combine完全相同。

这两种方法都有效：

  Uri final = new Uri(Regex.Replace(baseUrl + "/" + relativePath, "(?<!http:)/{2,}", "/"));

Or

  Uri final =new Uri(string.Format("{0}/{1}", baseUrl.ToString().TrimEnd('/'), relativePath.ToString().TrimStart('/')));

即，如果

baseUrl = "http://tesrurl.test.com/Int18"

and

relativePath = "To_Folder"

output = http://tesrurl.test.com/Int18/To_Folder

以下代码将出现一些错误：

 // If you use the below code, some issues will be there in the final URI
 Uri final = new Uri(baseUrl, relativePath);