简单地定义一个全局变量var1 = true。

Private Sub FileWatchman_Changed(ByVal sender As System.Object, ByVal e As System.IO.FileSystemEventArgs) Handles FileWatchman.Changed
   If var1 = true 
       your logic goes here
       var1 = false
   Else
       var1 = true 
   End If
End Sub

试试这个，效果很好

  private static readonly FileSystemWatcher Watcher = new FileSystemWatcher();
    static void Main(string[] args)
    {
        Console.WriteLine("Watching....");

        Watcher.Path = @"D:\Temp\Watcher";
        Watcher.Changed += OnChanged;
        Watcher.EnableRaisingEvents = true;
        Console.ReadKey();
    }

    static void OnChanged(object sender, FileSystemEventArgs e)
    {
        try
        {
            Watcher.Changed -= OnChanged;
            Watcher.EnableRaisingEvents = false;
            Console.WriteLine($"File Changed. Name: {e.Name}");
        }
        catch (Exception exception)
        {
            Console.WriteLine(exception);
        }
        finally
        {
            Watcher.Changed += OnChanged;
            Watcher.EnableRaisingEvents = true;
        }
    }

这里有一个你可以尝试的新解决方案。很适合我。在已更改事件的事件处理程序中，以编程方式从设计器输出中删除处理程序(如果需要的话)，然后以编程方式将处理程序添加回来。例子:

public void fileSystemWatcher1_Changed( object sender, System.IO.FileSystemEventArgs e )
    {            
        fileSystemWatcher1.Changed -= new System.IO.FileSystemEventHandler( fileSystemWatcher1_Changed );
        MessageBox.Show( "File has been uploaded to destination", "Success!" );
        fileSystemWatcher1.Changed += new System.IO.FileSystemEventHandler( fileSystemWatcher1_Changed );
    }

一个可能的“黑客”是使用响应式扩展来限制事件，例如:

var watcher = new FileSystemWatcher("./");

Observable.FromEventPattern<FileSystemEventArgs>(watcher, "Changed")
            .Throttle(new TimeSpan(500000))
            .Subscribe(HandleChangeEvent);

watcher.EnableRaisingEvents = true;

在本例中，我将设置为50ms，在我的系统上这就足够了，但更高的值应该更安全。(就像我说的，这仍然是一个“hack”)。

我改变了监视目录中的文件的方式。我没有使用FileSystemWatcher，而是在另一个线程上轮询位置，然后查看文件的LastWriteTime。

DateTime lastWriteTime = File.GetLastWriteTime(someFilePath);

使用这些信息并保持文件路径的索引和最近的写入时间，我可以确定在特定位置已更改或已创建的文件。这使我摆脱了FileSystemWatcher的奇怪之处。主要的缺点是您需要一个数据结构来存储LastWriteTime和对文件的引用，但是它是可靠且易于实现的。

代码可自定义禁用阻止第二个观察者升起的时间间隔，如果他们存在，则不阻止观察者:

    namespace Watcher
    {
        class Static
        {
            public static DateTime lastDomain { get; set; }
            public static string lastDomainStr { get; set; }
        }
        public partial class Form1 : Form
       {
            int minMs = 20;//time for blocking in ms
            public Form1()
            {
                InitializeComponent();
                Static.lastDomain = new DateTime(1970, 1, 1, 0, 0, 0);
                Static.lastDomainStr = "";  
                Start();
            }
             private void Start()//Start watcher
             {
                //...
                domain.Changed += new FileSystemEventHandler(Domain);
                domain.EnableRaisingEvents = true;
                //...you second unblocked watchers
                second.Changed += new FileSystemEventHandler(Second);
                second.EnableRaisingEvents = true;
             }
             private void Domain(object source, FileSystemEventArgs e)
             {
                if (now.Subtract(Static.lastDomain).TotalMilliseconds < minMs && Static.lastDomainStr == e.FullPath)return;
                 //...you code here
                 /* if you need form access
                 this.Invoke(new MethodInvoker(() =>{ textBox1.Text = "...";}));
                 */
                 Static.lastDomain = DateTime.Now;
                 Static.lastDomainStr = e.FullPath;
             }
             private void Second(object source, FileSystemEventArgs e)
             {
                  //...Second rised
             }
       }
    }