以读模式打开文件。以字符串格式读取文件。替换文本。关闭文件。再次以写模式打开文件。最后，将替换后的文本写入相同的文件。

try:
    with open("file_name", "r+") as text_file:
        texts = text_file.read()
        texts = texts.replace("to_replace", "replace_string")
    with open(file_name, "w") as text_file:
        text_file.write(texts)
except FileNotFoundError as f:
    print("Could not find the file you are trying to read.")

晚回答，但这是我用来在文本文件中查找和替换的:

with open("test.txt") as r:
  text = r.read().replace("THIS", "THAT")
with open("test.txt", "w") as w:
  w.write(text)

DEMO

你可以在python中使用sed、awk或grep(有一些限制)。这里有一个非常简单的例子。它在文件中把香蕉变成香蕉牙膏。你可以编辑和使用它。(我测试过了…注意:如果你在Windows下测试，你应该先安装sed命令并设置路径)

import os 
file="a.txt"
oldtext="Banana"
newtext=" BananaToothpaste"
os.system('sed -i "s/{}/{}/g" {}'.format(oldtext,newtext,file))
#print(f'sed -i "s/{oldtext}/{newtext}/g" {file}')
print('This command was applied:  sed -i "s/{}/{}/g" {}'.format(oldtext,newtext,file))

如果你想直接在文件上看到结果，应用:"type" for windows/ "cat" for linux:

####FOR WINDOWS:
os.popen("type " + file).read()
####FOR LINUX:
os.popen("cat " + file).read()

正如michaelb958所指出的，不能用不同长度的数据替换现有的部分，因为这会使其余部分不合适。我不同意其他人建议你从一个文件读到另一个文件。相反，我将把文件读入内存，修复数据，然后在单独的步骤中将其写入相同的文件。

# Read in the file
with open('file.txt', 'r') as file :
  filedata = file.read()

# Replace the target string
filedata = filedata.replace('abcd', 'ram')

# Write the file out again
with open('file.txt', 'w') as file:
  file.write(filedata)

除非你有一个巨大的文件要处理，它太大了，无法一次性加载到内存中，或者你担心如果在向文件写入数据的第二步过程中中断，可能会导致数据丢失。

使用re.subn可以对替换过程进行更多的控制，例如将单词分成两行，区分大小写的匹配。此外，它返回匹配的数量，如果没有找到字符串，可以使用这些匹配来避免浪费资源。

import re

file = # path to file

# they can be also raw string and regex
textToSearch = r'Ha.*O' # here an example with a regex
textToReplace = 'hallo'

# read and replace
with open(file, 'r') as fd:
    # sample case-insensitive find-and-replace
    text, counter = re.subn(textToSearch, textToReplace, fd.read(), re.I)

# check if there is at least a  match
if counter > 0:
    # edit the file
    with open(file, 'w') as fd:
        fd.write(text)

# summary result
print(f'{counter} occurence of "{textToSearch}" were replaced with "{textToReplace}".')

一些正则表达式:

添加re.I标志，re.IGNORECASE的缩写形式，用于不区分大小写的匹配 对于多行替换re.subn(r'\n*'.join(textToSearch)， textToReplace, fd.read()))，取决于数据也'\n{，1}'。注意，在这种情况下，textToSearch必须是纯字符串，而不是正则表达式!

我是这样做的:

#!/usr/bin/env python3

import fileinput
import os

Dir = input ("Source directory: ")
os.chdir(Dir)

Filelist = os.listdir()
print('File list: ',Filelist)

NomeFile = input ("Insert file name: ")

CarOr = input ("Text to search: ")

CarNew = input ("New text: ")

with fileinput.FileInput(NomeFile, inplace=True, backup='.bak') as file:
    for line in file:
        print(line.replace(CarOr, CarNew), end='')

file.close ()