以读模式打开文件。以字符串格式读取文件。替换文本。关闭文件。再次以写模式打开文件。最后，将替换后的文本写入相同的文件。

try:
    with open("file_name", "r+") as text_file:
        texts = text_file.read()
        texts = texts.replace("to_replace", "replace_string")
    with open(file_name, "w") as text_file:
        text_file.write(texts)
except FileNotFoundError as f:
    print("Could not find the file you are trying to read.")

您的问题源于读取和写入同一个文件。与其打开fileToSearch进行写入，不如打开一个实际的临时文件，然后在您完成并关闭tempFile之后，使用os。rename将新文件移动到fileToSearch上。

像这样:

def find_and_replace(file, word, replacement):
  with open(file, 'r+') as f:
    text = f.read()
    f.write(text.replace(word, replacement))

Fileinput已经支持就地编辑。在这种情况下，它将stdout重定向到文件:

#!/usr/bin/env python3
import fileinput

with fileinput.FileInput(filename, inplace=True, backup='.bak') as file:
    for line in file:
        print(line.replace(text_to_search, replacement_text), end='')

我的变种，在整个文件中一次一个词。

我把它读进了记忆。

def replace_word(infile,old_word,new_word):
    if not os.path.isfile(infile):
        print ("Error on replace_word, not a regular file: "+infile)
        sys.exit(1)

    f1=open(infile,'r').read()
    f2=open(infile,'w')
    m=f1.replace(old_word,new_word)
    f2.write(m)

Besides the answers already mentioned, here is an explanation of why you have some random characters at the end: You are opening the file in r+ mode, not w mode. The key difference is that w mode clears the contents of the file as soon as you open it, whereas r+ doesn't. This means that if your file content is "123456789" and you write "www" to it, you get "www456789". It overwrites the characters with the new input, but leaves any remaining input untouched. You can clear a section of the file contents by using truncate(<startPosition>), but you are probably best off saving the updated file content to a string first, then doing truncate(0) and writing it all at once. Or you can use my library :D