正如Jack Aidley发布的和J.F. Sebastian指出的那样，这个代码是行不通的:

 # Read in the file
filedata = None
with file = open('file.txt', 'r') :
  filedata = file.read()

# Replace the target string
filedata.replace('ram', 'abcd')

# Write the file out again
with file = open('file.txt', 'w') :
  file.write(filedata)`

但这段代码将工作(我已经测试过了):

f = open(filein,'r')
filedata = f.read()
f.close()

newdata = filedata.replace("old data","new data")

f = open(fileout,'w')
f.write(newdata)
f.close()

使用此方法，fileein和fileout可以是同一个文件，因为Python 3.3将在打开进行写入时覆盖该文件。

def word_replace(filename,old,new):
    c=0
    with open(filename,'r+',encoding ='utf-8') as f:
        a=f.read()
        b=a.split()
        for i in range(0,len(b)):
            if b[i]==old:
                c=c+1
        old=old.center(len(old)+2)
        new=new.center(len(new)+2)
        d=a.replace(old,new,c)
        f.truncate(0)
        f.seek(0)
        f.write(d)
    print('All words have been replaced!!!')

以读模式打开文件。以字符串格式读取文件。替换文本。关闭文件。再次以写模式打开文件。最后，将替换后的文本写入相同的文件。

try:
    with open("file_name", "r+") as text_file:
        texts = text_file.read()
        texts = texts.replace("to_replace", "replace_string")
    with open(file_name, "w") as text_file:
        text_file.write(texts)
except FileNotFoundError as f:
    print("Could not find the file you are trying to read.")

Besides the answers already mentioned, here is an explanation of why you have some random characters at the end: You are opening the file in r+ mode, not w mode. The key difference is that w mode clears the contents of the file as soon as you open it, whereas r+ doesn't. This means that if your file content is "123456789" and you write "www" to it, you get "www456789". It overwrites the characters with the new input, but leaves any remaining input untouched. You can clear a section of the file contents by using truncate(<startPosition>), but you are probably best off saving the updated file content to a string first, then doing truncate(0) and writing it all at once. Or you can use my library :D

我是这样做的:

#!/usr/bin/env python3

import fileinput
import os

Dir = input ("Source directory: ")
os.chdir(Dir)

Filelist = os.listdir()
print('File list: ',Filelist)

NomeFile = input ("Insert file name: ")

CarOr = input ("Text to search: ")

CarNew = input ("New text: ")

with fileinput.FileInput(NomeFile, inplace=True, backup='.bak') as file:
    for line in file:
        print(line.replace(CarOr, CarNew), end='')

file.close ()

我已经把这个作为一个课程的练习:打开文件，找到并替换字符串，并写入一个新文件。

class Letter:

    def __init__(self):

        with open("./Input/Names/invited_names.txt", "r") as file:
            # read the list of names
            list_names = [line.rstrip() for line in file]
            with open("./Input/Letters/starting_letter.docx", "r") as f:
                # read letter
                file_source = f.read()
            for name in list_names:
                with open(f"./Output/ReadyToSend/LetterTo{name}.docx", "w") as f:
                    # replace [name] with name of the list in the file
                    replace_string = file_source.replace('[name]', name)
                    # write to a new file
                    f.write(replace_string)


brief = Letter()