使用单个With块，您可以搜索和替换您的文本:

with open('file.txt','r+') as f:
    filedata = f.read()
    filedata = filedata.replace('abc','xyz')
    f.truncate(0)
    f.write(filedata)

Besides the answers already mentioned, here is an explanation of why you have some random characters at the end: You are opening the file in r+ mode, not w mode. The key difference is that w mode clears the contents of the file as soon as you open it, whereas r+ doesn't. This means that if your file content is "123456789" and you write "www" to it, you get "www456789". It overwrites the characters with the new input, but leaves any remaining input untouched. You can clear a section of the file contents by using truncate(<startPosition>), but you are probably best off saving the updated file content to a string first, then doing truncate(0) and writing it all at once. Or you can use my library :D

我稍微修改了Jayram Singh的帖子，以替换每一个'!'字符转换为一个数字，我想在每个实例中增加这个数字。我想这对那些想要修改每行出现不止一次的字符并且想要迭代的人可能会有帮助。希望这能帮助到别人。PS-我在编码方面很新，所以如果我的帖子在任何方面都不合适，我很抱歉，但这对我来说是有效的。

f1 = open('file1.txt', 'r')
f2 = open('file2.txt', 'w')
n = 1  

# if word=='!'replace w/ [n] & increment n; else append same word to     
# file2

for line in f1:
    for word in line:
        if word == '!':
            f2.write(word.replace('!', f'[{n}]'))
            n += 1
        else:
            f2.write(word)
f1.close()
f2.close()

我是这样做的:

#!/usr/bin/env python3

import fileinput
import os

Dir = input ("Source directory: ")
os.chdir(Dir)

Filelist = os.listdir()
print('File list: ',Filelist)

NomeFile = input ("Insert file name: ")

CarOr = input ("Text to search: ")

CarNew = input ("New text: ")

with fileinput.FileInput(NomeFile, inplace=True, backup='.bak') as file:
    for line in file:
        print(line.replace(CarOr, CarNew), end='')

file.close ()

我的变种，在整个文件中一次一个词。

我把它读进了记忆。

def replace_word(infile,old_word,new_word):
    if not os.path.isfile(infile):
        print ("Error on replace_word, not a regular file: "+infile)
        sys.exit(1)

    f1=open(infile,'r').read()
    f2=open(infile,'w')
    m=f1.replace(old_word,new_word)
    f2.write(m)

使用单个With块，您可以搜索和替换您的文本:

with open('file.txt','r+') as f:
    filedata = f.read()
    filedata = filedata.replace('abc','xyz')
    f.truncate(0)
    f.write(filedata)