使用re.subn可以对替换过程进行更多的控制，例如将单词分成两行，区分大小写的匹配。此外，它返回匹配的数量，如果没有找到字符串，可以使用这些匹配来避免浪费资源。

import re

file = # path to file

# they can be also raw string and regex
textToSearch = r'Ha.*O' # here an example with a regex
textToReplace = 'hallo'

# read and replace
with open(file, 'r') as fd:
    # sample case-insensitive find-and-replace
    text, counter = re.subn(textToSearch, textToReplace, fd.read(), re.I)

# check if there is at least a  match
if counter > 0:
    # edit the file
    with open(file, 'w') as fd:
        fd.write(text)

# summary result
print(f'{counter} occurence of "{textToSearch}" were replaced with "{textToReplace}".')

一些正则表达式:

添加re.I标志，re.IGNORECASE的缩写形式，用于不区分大小写的匹配 对于多行替换re.subn(r'\n*'.join(textToSearch)， textToReplace, fd.read()))，取决于数据也'\n{，1}'。注意，在这种情况下，textToSearch必须是纯字符串，而不是正则表达式!

我已经把这个作为一个课程的练习:打开文件，找到并替换字符串，并写入一个新文件。

class Letter:

    def __init__(self):

        with open("./Input/Names/invited_names.txt", "r") as file:
            # read the list of names
            list_names = [line.rstrip() for line in file]
            with open("./Input/Letters/starting_letter.docx", "r") as f:
                # read letter
                file_source = f.read()
            for name in list_names:
                with open(f"./Output/ReadyToSend/LetterTo{name}.docx", "w") as f:
                    # replace [name] with name of the list in the file
                    replace_string = file_source.replace('[name]', name)
                    # write to a new file
                    f.write(replace_string)


brief = Letter()

晚回答，但这是我用来在文本文件中查找和替换的:

with open("test.txt") as r:
  text = r.read().replace("THIS", "THAT")
with open("test.txt", "w") as w:
  w.write(text)

DEMO

以读模式打开文件。以字符串格式读取文件。替换文本。关闭文件。再次以写模式打开文件。最后，将替换后的文本写入相同的文件。

try:
    with open("file_name", "r+") as text_file:
        texts = text_file.read()
        texts = texts.replace("to_replace", "replace_string")
    with open(file_name, "w") as text_file:
        text_file.write(texts)
except FileNotFoundError as f:
    print("Could not find the file you are trying to read.")

def findReplace(find, replace):

    import os 

    src = os.path.join(os.getcwd(), os.pardir) 

    for path, dirs, files in os.walk(os.path.abspath(src)):

        for name in files: 

            if name.endswith('.py'): 

                filepath = os.path.join(path, name)

                with open(filepath) as f: 

                    s = f.read()

                s = s.replace(find, replace) 

                with open(filepath, "w") as f:

                    f.write(s) 

我是这样做的:

#!/usr/bin/env python3

import fileinput
import os

Dir = input ("Source directory: ")
os.chdir(Dir)

Filelist = os.listdir()
print('File list: ',Filelist)

NomeFile = input ("Insert file name: ")

CarOr = input ("Text to search: ")

CarNew = input ("New text: ")

with fileinput.FileInput(NomeFile, inplace=True, backup='.bak') as file:
    for line in file:
        print(line.replace(CarOr, CarNew), end='')

file.close ()