也许是一个简单的单行程序，具有相同或不同的列名。即使df2['Name2']包含重复的值也能正常工作。

newDf = df1.set_index('Name1')
           .drop(df2['Name2'], errors='ignore')
           .reset_index(drop=False)

定义数据框架:

df1 = pd.DataFrame({
    'Name':
        ['John','Mike','Smith','Wale','Marry','Tom','Menda','Bolt','Yuswa'],
    'Age':
        [23,45,12,34,27,44,28,39,40]
})

df2 = df1[df1.Name.isin(['John','Smith','Wale','Tom','Menda','Yuswa'])

df1

    Name  Age
0   John   23
1   Mike   45
2  Smith   12
3   Wale   34
4  Marry   27
5    Tom   44
6  Menda   28
7   Bolt   39
8  Yuswa   40

df2

    Name  Age
0   John   23
2  Smith   12
3   Wale   34
5    Tom   44
6  Menda   28
8  Yuswa   40

两者之间的区别是:

df1[~df1.isin(df2)].dropna()

    Name   Age
1   Mike  45.0
4  Marry  27.0
7   Bolt  39.0

地点:

isin(df2)返回df1中也在df2中的行。 ~(元素逻辑NOT)在表达式前面对结果求反，因此我们得到df1中不在df2中的元素——两者之间的差值。 .dropna()删除NaN显示所需输出的行

注意:这只适用于len(df1) >= len(df2)。如果df2比df1长，可以反转表达式:df2[~df2.isin(df1)].dropna()

nice @liangli的解决方案略有变化，不需要改变现有数据框架的索引:

newdf = df1.drop(df1.join(df2.set_index('Name').index))

通过索引查找差异。假设df1是df2的一个子集，并且在进行子集设置时将索引前移

df1.loc[set(df1.index).symmetric_difference(set(df2.index))].dropna()

# Example

df1 = pd.DataFrame({"gender":np.random.choice(['m','f'],size=5), "subject":np.random.choice(["bio","phy","chem"],size=5)}, index = [1,2,3,4,5])

df2 =  df1.loc[[1,3,5]]

df1

 gender subject
1      f     bio
2      m    chem
3      f     phy
4      m     bio
5      f     bio

df2

  gender subject
1      f     bio
3      f     phy
5      f     bio

df3 = df1.loc[set(df1.index).symmetric_difference(set(df2.index))].dropna()

df3

  gender subject
2      m    chem
4      m     bio

除了公认的答案，我想提出一个更广泛的解决方案，可以找到两个数据框架的2D集差异与任何索引/列(他们可能不符合两个数据框架)。此外，该方法允许设置浮动元素的容忍度，用于数据帧比较(它使用np.isclose)

import numpy as np
import pandas as pd

def get_dataframe_setdiff2d(df_new: pd.DataFrame, 
                            df_old: pd.DataFrame, 
                            rtol=1e-03, atol=1e-05) -> pd.DataFrame:
    """Returns set difference of two pandas DataFrames"""

    union_index = np.union1d(df_new.index, df_old.index)
    union_columns = np.union1d(df_new.columns, df_old.columns)

    new = df_new.reindex(index=union_index, columns=union_columns)
    old = df_old.reindex(index=union_index, columns=union_columns)

    mask_diff = ~np.isclose(new, old, rtol, atol)

    df_bool = pd.DataFrame(mask_diff, union_index, union_columns)

    df_diff = pd.concat([new[df_bool].stack(),
                         old[df_bool].stack()], axis=1)

    df_diff.columns = ["New", "Old"]

    return df_diff

例子:

In [1]

df1 = pd.DataFrame({'A':[2,1,2],'C':[2,1,2]})
df2 = pd.DataFrame({'A':[1,1],'B':[1,1]})

print("df1:\n", df1, "\n")

print("df2:\n", df2, "\n")

diff = get_dataframe_setdiff2d(df1, df2)

print("diff:\n", diff, "\n")

Out [1]

df1:
   A  C
0  2  2
1  1  1
2  2  2 

df2:
   A  B
0  1  1
1  1  1 

diff:
     New  Old
0 A  2.0  1.0
  B  NaN  1.0
  C  2.0  NaN
1 B  NaN  1.0
  C  1.0  NaN
2 A  2.0  NaN
  C  2.0  NaN 

试试这个: Df_new = df1。merge(df2, how='outer'， indicator=True)。查询('_merge == "left_only"')。下降(_merge, 1)

它将产生一个新的数据框架，其差异是:df1中存在的值，而df2中不存在。