下面是一些代码，据我所知，它与接受的答案相同，但代码更少:

    public static bool IsFileLocked(string file)
    {
        try
        {
            using (var stream = File.OpenRead(file))
                return false;
        }
        catch (IOException)
        {
            return true;
        }        
    }

然而，我认为用以下方式来做会更稳健:

    public static void TryToDoWithFileStream(string file, Action<FileStream> action, 
        int count, int msecTimeOut)
    {
        FileStream stream = null;
        for (var i = 0; i < count; ++i)
        {
            try
            {
                stream = File.OpenRead(file);
                break;
            }
            catch (IOException)
            {
                Thread.Sleep(msecTimeOut);
            }
        }
        action(stream);
    }

static bool FileInUse(string path)
    {
        try
        {
            using (FileStream fs = new FileStream(path, FileMode.OpenOrCreate))
            {
                fs.CanWrite
            }
            return false;
        }
        catch (IOException ex)
        {
            return true;
        }
    }

string filePath = "C:\\Documents And Settings\\yourfilename";
bool isFileInUse;

isFileInUse = FileInUse(filePath);

// Then you can do some checking
if (isFileInUse)
   Console.WriteLine("File is in use");
else
   Console.WriteLine("File is not in use");

希望这能有所帮助!

我很有兴趣看看这是否会引发任何WTF反射。我有一个进程，它创建并随后从控制台应用程序启动PDF文档。然而，我正在处理一个弱点，如果用户要多次运行该进程，生成相同的文件而不首先关闭先前生成的文件，应用程序将抛出异常并死亡。这是一个相当常见的情况，因为文件名是基于销售报价数字的。

与其以这种不体面的方式失败，我决定依靠自动递增的文件版本控制:

private static string WriteFileToDisk(byte[] data, string fileName, int version = 0)
{
    try
    {
        var versionExtension = version > 0 ? $"_{version:000}" : string.Empty;
        var filePath = Path.Combine(AppDomain.CurrentDomain.BaseDirectory, $"{fileName}{versionExtension}.pdf");
        using (var writer = new FileStream(filePath, FileMode.Create))
        {
            writer.Write(data, 0, data.Length);
        }
        return filePath;
    }
    catch (IOException)
    {
        return WriteFileToDisk(data, fileName, ++version);
    }
}

可能需要对catch块多加注意，以确保捕获了正确的IOException(s)。我可能还会在启动时清除应用程序存储，因为这些文件是临时的。

我意识到这超出了OP的问题范围，即简单地检查文件是否在使用，但这确实是我到达这里时希望解决的问题，所以也许它对其他人有用。

尝试将文件移动/复制到临时目录。如果可以的话，它没有锁，您可以安全地在临时目录中工作而不需要锁。否则就在x秒内再移动一次。

也许您可以使用FileSystemWatcher并观察“已更改”事件。

我自己还没用过这个，但也许值得一试。如果对于这种情况，文件系统监控器显得有点重，那么我将使用try/catch/sleep循环。

I once needed to upload PDFs to an online backup archive. But the backup would fail if the user had the file open in another program (such as PDF reader). In my haste, I attempted a few of the top answers in this thread but could not get them to work. What did work for me was trying to move the PDF file to its own directory. I found that this would fail if the file was open in another program, and if the move were successful there would be no restore-operation required as there would be if it were moved to a separate directory. I want to post my basic solution in case it may be useful for others' specific use cases.

string str_path_and_name = str_path + '\\' + str_filename;
FileInfo fInfo = new FileInfo(str_path_and_name);
bool open_elsewhere = false;
try
{
    fInfo.MoveTo(str_path_and_name);
}
catch (Exception ex)
{
    open_elsewhere = true;
}

if (open_elsewhere)
{
    //handle case
}