public static String getFileType(Uri file)
{
    try
    {
        if (file.getScheme().equals(ContentResolver.SCHEME_CONTENT))
            return subStringFromLastMark(SystemMaster.getContentResolver().getType(file), "/");
        else
            return MimeTypeMap.getFileExtensionFromUrl(file.toString()).toLowerCase();
    }
    catch(Exception e)
    {
        return null;
    }
}

public static String getMimeType(Uri file)
{
    try
    {
        return MimeTypeMap.getSingleton().getMimeTypeFromExtension(getFileType(file));
    }
    catch(Exception e)
    {
        return null;
    }
}

public static String subStringFromLastMark(String str,String mark)
{
    int l = str.lastIndexOf(mark);
    int end = str.length();
    if(l == -1)
        return str;

    return str.substring(l + 1, end);
}

我尝试使用标准方法来确定mime类型，但我不能使用MimeTypeMap.getFileExtensionFromUrl(uri.getPath())保留文件扩展名。这个方法返回一个空字符串。所以我做了一个重要的解决方案来保留文件扩展名。

下面是返回文件扩展名的方法:

private String getExtension(String fileName){
    char[] arrayOfFilename = fileName.toCharArray();
    for(int i = arrayOfFilename.length-1; i > 0; i--){
        if(arrayOfFilename[i] == '.'){
            return fileName.substring(i+1, fileName.length());
        }
    }
    return "";
}

并且保留了文件扩展名，可以获得如下所示的mime类型:

public String getMimeType(File file) {
    String mimeType = "";
    String extension = getExtension(file.getName());
    if (MimeTypeMap.getSingleton().hasExtension(extension)) {
        mimeType = MimeTypeMap.getSingleton().getMimeTypeFromExtension(extension);
    }
    return mimeType;
}

Jens的回答的优化版本与零安全和回退类型。

@NonNull
static String getMimeType(@NonNull File file) {
    String type = null;
    final String url = file.toString();
    final String extension = MimeTypeMap.getFileExtensionFromUrl(url);
    if (extension != null) {
        type = MimeTypeMap.getSingleton().getMimeTypeFromExtension(extension.toLowerCase());
    }
    if (type == null) {
        type = "image/*"; // fallback type. You might set it to */*
    }
    return type;
}

重要:getFileExtensionFromUrl()只适用于小写字母!

更新(19.03.2018)

好处:上面的方法是一个不那么冗长的Kotlin扩展函数:

fun File.getMimeType(fallback: String = "image/*"): String {
    return MimeTypeMap.getFileExtensionFromUrl(toString())
            ?.run { MimeTypeMap.getSingleton().getMimeTypeFromExtension(toLowerCase()) }
            ?: fallback // You might set it to */*
}

首先，你应该考虑调用MimeTypeMap#getMimeTypeFromExtension()，就像这样:

// url = file path or whatever suitable URL you want.
public static String getMimeType(String url) {
    String type = null;
    String extension = MimeTypeMap.getFileExtensionFromUrl(url);
    if (extension != null) {
        type = MimeTypeMap.getSingleton().getMimeTypeFromExtension(extension);
    }
    return type;
}

对于Xamarin Android(来自@HoaLe的回答)

public String getMimeType(Uri uri) {
    String mimeType = null;
    if (uri.Scheme.Equals(ContentResolver.SchemeContent))
    {
        ContentResolver cr = Application.Context.ContentResolver;
        mimeType = cr.GetType(uri);
    }
    else
    {
        String fileExtension = MimeTypeMap.GetFileExtensionFromUrl(uri.ToString());
        mimeType = MimeTypeMap.Singleton.GetMimeTypeFromExtension(
        fileExtension.ToLower());
    }
    return mimeType;
}

而从资产/文件(注意，在MimeTypeMap中缺少一些情况)。

private String getMimeType(String path) {
    if (null == path) return "*/*";

    String extension = path;
    int lastDot = extension.lastIndexOf('.');
    if (lastDot != -1) {
        extension = extension.substring(lastDot + 1);
    }

    // Convert the URI string to lower case to ensure compatibility with MimeTypeMap (see CB-2185).
    extension = extension.toLowerCase(Locale.getDefault());
    if (extension.equals("3ga")) {
        return "audio/3gpp";
    } else if (extension.equals("js")) {
        return "text/javascript";
    } else if (extension.equals("woff")) {
        return "application/x-font-woff";
    } else {
        // TODO
        // anyting missing from the map (http://www.sitepoint.com/web-foundations/mime-types-complete-list/)
        // reference: http://grepcode.com/file/repo1.maven.org/maven2/com.google.okhttp/okhttp/20120626/libcore/net/MimeUtils.java#MimeUtils
    }

    return MimeTypeMap.getSingleton().getMimeTypeFromExtension(extension);
}

而使用ContentResolver

contentResolver.getType(uri)

当http/https请求

    try {
        HttpURLConnection conn = httpClient.open(new URL(uri.toString()));
        conn.setDoInput(false);
        conn.setRequestMethod("HEAD");
        return conn.getHeaderField("Content-Type");
    } catch (IOException e) {
    }