我使用类似于@Ofaim的方法

private bool jobSaved = true;
private bool JobSaved    
{ 
    get => jobSaved; 
    set
    {
        if (value == jobSaved) return;
        jobSaved = value;

        OnPropertyChanged();
        OnPropertyChanged("EnableSaveButton");
    }
}

public bool EnableSaveButton => !jobSaved;

你可以使用ValueConverter来反转bool属性。

XAML:

IsEnabled="{Binding Path=IsReadOnly, Converter={StaticResource InverseBooleanConverter}}"

转换器:

[ValueConversion(typeof(bool), typeof(bool))]
    public class InverseBooleanConverter: IValueConverter
    {
        #region IValueConverter Members

        public object Convert(object value, Type targetType, object parameter,
            System.Globalization.CultureInfo culture)
        {
            if (targetType != typeof(bool))
                throw new InvalidOperationException("The target must be a boolean");

            return !(bool)value;
        }

        public object ConvertBack(object value, Type targetType, object parameter,
            System.Globalization.CultureInfo culture)
        {
            throw new NotSupportedException();
        }

        #endregion
    }

你考虑过IsNotReadOnly属性吗?如果被绑定的对象是MVVM域中的ViewModel，那么附加属性非常有意义。如果它是一个直接的实体模型，您可能会考虑组合并将实体的专用ViewModel呈现给表单。

I did something very similar. I created my property behind the scenes that enabled the selection of a combobox ONLY if it had finished searching for data. When my window first appears, it launches an async loaded command but I do not want the user to click on the combobox while it is still loading data (would be empty, then would be populated). So by default the property is false so I return the inverse in the getter. Then when I'm searching I set the property to true and back to false when complete.

private bool _isSearching;
public bool IsSearching
{
    get { return !_isSearching; }
    set
    {
        if(_isSearching != value)
        {
            _isSearching = value;
            OnPropertyChanged("IsSearching");
        }
    }
}

public CityViewModel()
{
    LoadedCommand = new DelegateCommandAsync(LoadCity, LoadCanExecute);
}

private async Task LoadCity(object pArg)
{
    IsSearching = true;

    //**Do your searching task here**

    IsSearching = false;
}

private bool LoadCanExecute(object pArg)
{
    return IsSearching;
}

然后，对于组合框，我可以直接绑定到IsSearching:

<ComboBox ItemsSource="{Binding Cities}" IsEnabled="{Binding IsSearching}" DisplayMemberPath="City" />

我建议使用https://github.com/JohannesMoersch/QuickConverter

反转一个布尔值就像这样简单: <Button IsEnabled="{qc:正在绑定'!$P'， P={正在绑定IsReadOnly}}" />

这加快了编写转换器通常所需的时间。

在视图模型中再添加一个属性，它将返回反向值。 然后把它绑定到按钮上。 像;

视图模型:

public bool IsNotReadOnly{get{return !IsReadOnly;}}

在xaml:

IsEnabled="{Binding IsNotReadOnly"}