如果你想重用HttpClient，建议不要使用DefaultRequestHeaders，因为它们是用来发送每个请求的。

你可以试试这个:

var requestMessage = new HttpRequestMessage
    {
        Method = HttpMethod.Post,
        Content = new StringContent("...", Encoding.UTF8, "application/json"),
        RequestUri = new Uri("...")
    };

requestMessage.Headers.Authorization = new AuthenticationHeaderValue("Basic", 
    Convert.ToBase64String(System.Text.ASCIIEncoding.ASCII.GetBytes($"{user}:{password}")));

var response = await _httpClient.SendAsync(requestMessage);

request.DefaultRequestHeaders.Authorization = 
    new AuthenticationHeaderValue(
        "Basic", Convert.ToBase64String(
            System.Text.ASCIIEncoding.ASCII.GetBytes(
               $"{yourusername}:{yourpwd}")));

使用基本授权和Json参数。

using (HttpClient client = new HttpClient())
{
    var request_json = "your json string";

    var content = new StringContent(request_json, Encoding.UTF8, "application/json");

    var authenticationBytes = Encoding.ASCII.GetBytes("YourUsername:YourPassword");

    client.DefaultRequestHeaders.Authorization = new AuthenticationHeaderValue("Basic",
            Convert.ToBase64String(authenticationBytes));
    client.DefaultRequestHeaders.Accept.Add(new MediaTypeWithQualityHeaderValue("application/json"));

    var result = await client.PostAsync("YourURL", content);

    var result_string = await result.Content.ReadAsStringAsync();
}

方法是这样的，

httpClient.DefaultRequestHeaders.Authorization =
    new AuthenticationHeaderValue("Bearer", "Your Oauth token");

这可能有助于设置标题:

WebClient client = new WebClient();

string authInfo = this.credentials.UserName + ":" + this.credentials.Password;
authInfo = Convert.ToBase64String(Encoding.Default.GetBytes(authInfo));
client.Headers["Authorization"] = "Basic " + authInfo;

我在寻找一个好的方法来处理这个问题，我也在考虑同样的问题。希望这个答案能帮助到每个和我一样有同样问题的人。

using (var client = new HttpClient())
{
    var url = "https://www.theidentityhub.com/{tenant}/api/identity/v1";
    client.DefaultRequestHeaders.Add("Authorization", "Bearer " + accessToken);
    var response = await client.GetStringAsync(url);
    // Parse JSON response.
    ....
}

参考来自https://www.theidentityhub.com/hub/Documentation/CallTheIdentityHubApi