我编写了一个util函数来实现这个目的。你可以看看：

// adjust the height of a multi-line label to make it align vertical with top
+ (void) alignLabelWithTop:(UILabel *)label {
  CGSize maxSize = CGSizeMake(label.frame.size.width, 999);
  label.adjustsFontSizeToFitWidth = NO;

  // get actual height
  CGSize actualSize = [label.text sizeWithFont:label.font constrainedToSize:maxSize lineBreakMode:label.lineBreakMode];
  CGRect rect = label.frame;
  rect.size.height = actualSize.height;
  label.frame = rect;
}

.如何使用？（如果lblHello是由Interface builder创建的，所以我跳过了一些UILabel属性的详细信息）

lblHello.text = @"Hello World! Hello World! Hello World! Hello World! Hello World! Hello World! Hello World! Hello World!";
lblHello.numberOfLines = 5;
[Utils alignLabelWithTop:lblHello];

我还在博客上写了一篇文章：http://fstoke.me/blog/?p=2819

Swift 4.0中有一个解决方案：

func viewDidLoad() {

    super.viewDidLoad()

    // 20 point top and left margin. Sized to leave 20 pt at right.
    let labelFrame = CGRect(x: 20, y: 20, width: 280, height: 150)
    let myLabel = UILabel(frame: labelFrame)
    myLabel.backgroundColor = UIColor.orange

    let labelText = "I am the very model of a modern Major-General, 
    I've information vegetable, animal, and mineral"
    myLabel.text = labelText

    // Tell the label to use an unlimited number of lines
    myLabel.numberOfLines = 0
    myLabel.sizeToFit()

    view.addSubview(myLabel) // add label
}

您可以手动更改标签的高度，而不是使用sizeToFit；

CGSize size = [descLabel.text sizeWithFont:descLabel.font constrainedToSize:CGSizeMake(labelWidth, labelHeight)];
CGRect frame = descLabel.frame;
frame.size.height = size.height;    
[yourLabel setFrame:frame];

返回的尺寸将最适合标签的内容。如果标签的高度适合其内容，则内容位于标签中心时不会出现问题。

我发现这个问题的答案现在有点过时了，所以为汽车布局爱好者添加这个。

自动布局使这个问题变得非常微不足道。假设我们要将标签添加到UIView*视图中，以下代码将完成此操作：

UILabel *label = [[UILabel alloc] initWithFrame:CGRectZero];
[label setText:@"Some text here"];
[label setTranslatesAutoresizingMaskIntoConstraints:NO];
[view addSubview:label];

[view addConstraints:[NSLayoutConstraint constraintsWithVisualFormat:@"H:|[label]|" options:0 metrics:nil views:@{@"label": label}]];
[view addConstraints:[NSLayoutConstraint constraintsWithVisualFormat:@"V:|[label]" options:0 metrics:nil views:@{@"label": label}]];

标签的高度将自动计算（使用其intrinsicContentSize），标签将在视图顶部水平放置。

就像上面的答案一样，但它不太正确，或者很容易插入代码，所以我稍微清理了一下。将此扩展名添加到它自己的.h和.m文件中，或者直接粘贴到您打算使用的实现上方：

#pragma mark VerticalAlign
@interface UILabel (VerticalAlign)
- (void)alignTop;
- (void)alignBottom;
@end


@implementation UILabel (VerticalAlign)
- (void)alignTop
{
    CGSize fontSize = [self.text sizeWithFont:self.font];

    double finalHeight = fontSize.height * self.numberOfLines;
    double finalWidth = self.frame.size.width;    //expected width of label


    CGSize theStringSize = [self.text sizeWithFont:self.font constrainedToSize:CGSizeMake(finalWidth, finalHeight) lineBreakMode:self.lineBreakMode];


    int newLinesToPad = (finalHeight  - theStringSize.height) / fontSize.height;

    for(int i=0; i<= newLinesToPad; i++)
    {
        self.text = [self.text stringByAppendingString:@" \n"];
    }
}

- (void)alignBottom
{
    CGSize fontSize = [self.text sizeWithFont:self.font];

    double finalHeight = fontSize.height * self.numberOfLines;
    double finalWidth = self.frame.size.width;    //expected width of label


    CGSize theStringSize = [self.text sizeWithFont:self.font constrainedToSize:CGSizeMake(finalWidth, finalHeight) lineBreakMode:self.lineBreakMode];


    int newLinesToPad = (finalHeight  - theStringSize.height) / fontSize.height;

    for(int i=0; i< newLinesToPad; i++)
    {
        self.text = [NSString stringWithFormat:@" \n%@",self.text];
    }
}
@end

然后要使用，请将文本放入标签中，然后调用适当的方法将其对齐：

[myLabel alignTop];

or

[myLabel alignBottom];

Swift 2.0版本：

在空Swift文件中生成常量枚举值。

//  AppRef.swift

import UIKit
import Foundation

enum UILabelTextPositions : String {

 case VERTICAL_ALIGNMENT_TOP = "VerticalAlignmentTop"
 case VERTICAL_ALIGNMENT_MIDDLE = "VerticalAlignmentMiddle"
 case VERTICAL_ALIGNMENT_BOTTOM = "VerticalAlignmentBottom"

}

使用UILabel扩展：

创建一个空的Swift类并命名它

//  AppExtensions.swift

import Foundation
import UIKit

extension UILabel{ 
 func makeLabelTextPosition (sampleLabel :UILabel?, positionIdentifier : String) -> UILabel
 {
  let rect = sampleLabel!.textRectForBounds(bounds, limitedToNumberOfLines: 0)

  switch positionIdentifier
  {
  case "VerticalAlignmentTop":
   sampleLabel!.frame = CGRectMake(bounds.origin.x+5, bounds.origin.y, rect.size.width, rect.size.height)
   break;

  case "VerticalAlignmentMiddle":
   sampleLabel!.frame = CGRectMake(bounds.origin.x+5,bounds.origin.y + (bounds.size.height - rect.size.height) / 2,
    rect.size.width, rect.size.height);
   break;

  case "VerticalAlignmentBottom":
   sampleLabel!.frame = CGRectMake(bounds.origin.x+5, bounds.origin.y + (bounds.size.height - rect.size.height),rect.size.width, rect.size.height);
   break;

  default:
   sampleLabel!.frame = bounds;
   break;
  }
  return sampleLabel!

 }
}

用法：

myMessageLabel.makeLabelTextPosition(messageLabel, positionIdentifier: UILabelTextPositions.VERTICAL_ALIGNMENT_TOP.rawValue)