我接受了这里的建议，并创建了一个可以包装UILabel的视图，它将调整大小并设置行数，使其顶部对齐。只需将UILabel作为子视图：

@interface TopAlignedLabelContainer : UIView
{
}

@end

@implementation TopAlignedLabelContainer

- (void)layoutSubviews
{
    CGRect bounds = self.bounds;

    for (UILabel *label in [self subviews])
    {
        if ([label isKindOfClass:[UILabel class]])
        {
            CGSize fontSize = [label.text sizeWithFont:label.font];

            CGSize textSize = [label.text sizeWithFont:label.font
                                     constrainedToSize:bounds.size
                                         lineBreakMode:label.lineBreakMode];

            label.numberOfLines = textSize.height / fontSize.height;

            label.frame = CGRectMake(0, 0, textSize.width,
                 fontSize.height * label.numberOfLines);
        }
    }
}

@end

子类UILabel并约束绘图矩形，如下所示：

- (void)drawTextInRect:(CGRect)rect
{
    CGSize sizeThatFits = [self sizeThatFits:rect.size];
    rect.size.height = MIN(rect.size.height, sizeThatFits.height);

    [super drawTextInRect:rect];
}

我尝试了涉及换行填充的解决方案，在某些情况下遇到了错误的行为。根据我的经验，如上所述约束绘图矩形比使用numberOfLines更容易。

P.S.你可以想象一下这样轻松地支持UIViewContentMode：

- (void)drawTextInRect:(CGRect)rect
{
    CGSize sizeThatFits = [self sizeThatFits:rect.size];

    if (self.contentMode == UIViewContentModeTop) {
        rect.size.height = MIN(rect.size.height, sizeThatFits.height);
    }
    else if (self.contentMode == UIViewContentModeBottom) {
        rect.origin.y = MAX(0, rect.size.height - sizeThatFits.height);
        rect.size.height = MIN(rect.size.height, sizeThatFits.height);
    }

    [super drawTextInRect:rect];
}

如果您使用的是自动布局，请在代码或IB中将垂直内容HuggingPriority设置为1000。在IB中，您可能需要通过将其优先级设置为1然后删除来删除高度限制。

Swift 4.0中有一个解决方案：

func viewDidLoad() {

    super.viewDidLoad()

    // 20 point top and left margin. Sized to leave 20 pt at right.
    let labelFrame = CGRect(x: 20, y: 20, width: 280, height: 150)
    let myLabel = UILabel(frame: labelFrame)
    myLabel.backgroundColor = UIColor.orange

    let labelText = "I am the very model of a modern Major-General, 
    I've information vegetable, animal, and mineral"
    myLabel.text = labelText

    // Tell the label to use an unlimited number of lines
    myLabel.numberOfLines = 0
    myLabel.sizeToFit()

    view.addSubview(myLabel) // add label
}

我接受了这里的建议，并创建了一个可以包装UILabel的视图，它将调整大小并设置行数，使其顶部对齐。只需将UILabel作为子视图：

@interface TopAlignedLabelContainer : UIView
{
}

@end

@implementation TopAlignedLabelContainer

- (void)layoutSubviews
{
    CGRect bounds = self.bounds;

    for (UILabel *label in [self subviews])
    {
        if ([label isKindOfClass:[UILabel class]])
        {
            CGSize fontSize = [label.text sizeWithFont:label.font];

            CGSize textSize = [label.text sizeWithFont:label.font
                                     constrainedToSize:bounds.size
                                         lineBreakMode:label.lineBreakMode];

            label.numberOfLines = textSize.height / fontSize.height;

            label.frame = CGRectMake(0, 0, textSize.width,
                 fontSize.height * label.numberOfLines);
        }
    }
}

@end

创建UILabel的子类。就像一个魅力：

// TopLeftLabel.h

#import <Foundation/Foundation.h>

@interface TopLeftLabel : UILabel 
{
}

@end

// TopLeftLabel.m

#import "TopLeftLabel.h"

@implementation TopLeftLabel

- (id)initWithFrame:(CGRect)frame 
{
    return [super initWithFrame:frame];
}

- (CGRect)textRectForBounds:(CGRect)bounds limitedToNumberOfLines:(NSInteger)numberOfLines 
{
    CGRect textRect = [super textRectForBounds:bounds limitedToNumberOfLines:numberOfLines];    
    textRect.origin.y = bounds.origin.y;
    return textRect;
}

-(void)drawTextInRect:(CGRect)requestedRect 
{
    CGRect actualRect = [self textRectForBounds:requestedRect limitedToNumberOfLines:self.numberOfLines];
    [super drawTextInRect:actualRect];
}

@end

正如这里所讨论的。