我很长一段时间都在纠结这个问题，我想分享我的解决方案。

这将为您提供一个UILabel，它将自动将文本缩小到0.5个刻度，并将文本垂直居中。故事板/IB中也提供了这些选项。

[labelObject setMinimumScaleFactor:0.5];
[labelObject setBaselineAdjustment:UIBaselineAdjustmentAlignCenters];

您可以手动更改标签的高度，而不是使用sizeToFit；

CGSize size = [descLabel.text sizeWithFont:descLabel.font constrainedToSize:CGSizeMake(labelWidth, labelHeight)];
CGRect frame = descLabel.frame;
frame.size.height = size.height;    
[yourLabel setFrame:frame];

返回的尺寸将最适合标签的内容。如果标签的高度适合其内容，则内容位于标签中心时不会出现问题。

我希望有一个标签能够有多行，最小字体大小，并在父视图中水平和垂直居中。我以编程方式将标签添加到视图中：

- (void) customInit {
    // Setup label
    self.label = [[UILabel alloc] initWithFrame:CGRectMake(0, 0, self.frame.size.width, self.frame.size.height)];
    self.label.numberOfLines = 0;
    self.label.lineBreakMode = UILineBreakModeWordWrap;
    self.label.textAlignment = UITextAlignmentCenter;

    // Add the label as a subview
    self.autoresizesSubviews = YES;
    [self addSubview:self.label];
}

然后当我想更改标签的文本时。。。

- (void) updateDisplay:(NSString *)text {
    if (![text isEqualToString:self.label.text]) {
        // Calculate the font size to use (save to label's font)
        CGSize textConstrainedSize = CGSizeMake(self.frame.size.width, INT_MAX);
        self.label.font = [UIFont systemFontOfSize:TICKER_FONT_SIZE];
        CGSize textSize = [text sizeWithFont:self.label.font constrainedToSize:textConstrainedSize];
        while (textSize.height > self.frame.size.height && self.label.font.pointSize > TICKER_MINIMUM_FONT_SIZE) {
            self.label.font = [UIFont systemFontOfSize:self.label.font.pointSize-1];
            textSize = [ticker.blurb sizeWithFont:self.label.font constrainedToSize:textConstrainedSize];
        }
        // In cases where the frame is still too large (when we're exceeding minimum font size),
        // use the views size
        if (textSize.height > self.frame.size.height) {
            textSize = [text sizeWithFont:self.label.font constrainedToSize:self.frame.size];
        }

        // Draw 
        self.label.frame = CGRectMake(0, self.frame.size.height/2 - textSize.height/2, self.frame.size.width, textSize.height);
        self.label.text = text;
    }
    [self setNeedsDisplay];
}

希望这对某人有所帮助！

在发布的所有其他解决方案的基础上，我创建了一个简单的小UILabel子类，在设置其对齐属性时将为您处理垂直对齐。这还将在方向更改时更新标签，将高度约束到文本，并将标签的宽度保持在其原始大小。

.h

@interface VAlignLabel : UILabel
@property (nonatomic, assign) WBZVerticalAlignment alignment;
@end


.m

 -(void)setAlignment:(WBZVerticalAlignment)alignment{

    _alignment = alignment;

    CGSize s = [self.text sizeWithFont:self.font constrainedToSize:CGSizeMake(self.frame.size.width, 9999) lineBreakMode:NSLineBreakByWordWrapping];

    switch (_alignment)
    {
        case wbzLabelAlignmentVerticallyTop:
            self.frame = CGRectMake(self.frame.origin.x, self.frame.origin.y, self.frame.size.width, s.height);
            break;
        case wbzLabelAlignmentVerticallyMiddle:
            self.frame = CGRectMake(self.frame.origin.x, self.frame.origin.y + (self.frame.size.height - s.height)/2, self.frame.size.width, s.height);
            break;
        case wbzLabelAlignmentVerticallyBottom:
            self.frame = CGRectMake(self.frame.origin.x, self.frame.origin.y + (self.frame.size.height - s.height), self.frame.size.width, s.height);
            break;
        default:
            break;
    }
}

-(void)layoutSubviews{
    [self setAlignment:self.alignment];
}

如果您使用的是自动布局，请在代码或IB中将垂直内容HuggingPriority设置为1000。在IB中，您可能需要通过将其优先级设置为1然后删除来删除高度限制。

我接受了这里的建议，并创建了一个可以包装UILabel的视图，它将调整大小并设置行数，使其顶部对齐。只需将UILabel作为子视图：

@interface TopAlignedLabelContainer : UIView
{
}

@end

@implementation TopAlignedLabelContainer

- (void)layoutSubviews
{
    CGRect bounds = self.bounds;

    for (UILabel *label in [self subviews])
    {
        if ([label isKindOfClass:[UILabel class]])
        {
            CGSize fontSize = [label.text sizeWithFont:label.font];

            CGSize textSize = [label.text sizeWithFont:label.font
                                     constrainedToSize:bounds.size
                                         lineBreakMode:label.lineBreakMode];

            label.numberOfLines = textSize.height / fontSize.height;

            label.frame = CGRectMake(0, 0, textSize.width,
                 fontSize.height * label.numberOfLines);
        }
    }
}

@end