我也有同样的问题。请遵循以下步骤:

确保你已经安装了System.Data.SQLite.Core包 来自NuGet的SQLite开发团队。 转到项目解决方案，并尝试在包文件夹内找到构建文件夹 检查您的项目框架并选择所需的SQLite.Interop.dll并将其放置在调试/发布文件夹中

参考

I don't know why this has not been included yet, but I had to do the research and find this out for myself, so hopefully someone will find this answer and be saved the trouble. This was for a WPF app. It worked fine on my Dev box, but did not work on the computer where I was copying it and got the Unable to load DLL 'SQLite.Interop.dll' error. I ported over all of its associated directories and files, directly from my "Debug" folder to this other computer when I got the same error as the OP when I ran it. My "bin" folder that contained my DLLs had been copied to "Debug\bin" and all were included, along with my application files when I did my copying to the other computer using this path, so it was not missing any files.

我在其他答案中看到的不适用的东西:

I did not use the NuGet package or need to create x86 or x64 folders that it seems that NuGet package creates. My DLLs (System.Data.SQLite and SQLite.Interop.dll, along with System.Data.SQLite.config) are in the "bin" folder in my project and were copied in manually (create "bin" folder in Solution Explorer in VS, paste DLLs into this folder in Windows Explorer, use Add > Existing Item to bring files into VS folder/project). Then I reference them as Referenced Assemblies in my project using that location ("References" > "Add Reference", and browse to one, rinse, repeat for the rest). This ensures my project knows exactly where they are. I did not need to reference any SQLite DLL file in my app.config or even touch my MyProject.csproj file. I did not even need to specify a particular processor! My project's build is for "Any CPU", even though I have only mixed or 64-bit DLLs and will only be running on Windows 7+, which are 64-bit OSes. (no x86-only/32-bit solely DLLs) I was already specifying them as "Content" and "copy if newer" for these DLLs when I experienced the OP's error.

我从https://system.data.sqlite.org/index.html/doc/trunk/www/faq.wiki#q20上找到了这个:

(11) Why do I get a DllNotFoundException (for "sqlite3.dll" or "SQLite.Interop.dll") when trying to run my application? Either the named dynamic link library (DLL) cannot be located or it cannot be loaded due to missing dependencies. Make sure the named dynamic link library is located in the application directory or a directory along the system PATH and try again. Also, be sure the necessary Visual C++ runtime redistributable has been installed unless you are using a dynamic link library that was built statically linked to it.

我要强调这段内粗体的部分。目标计算机是新的，除了. net 4.0之外没有加载任何程序。一旦我安装了c++，它就能够完成SQLite的命令。这应该是第一个常见问题之一，也是先决条件的一部分，但它被埋在了第11位。我的开发计算机已经加载了它，因为它带有Visual Studio，所以这就是它在那里工作的原因。

下载: Visual c++ Redistributable for Visual Studio 2015 https://www.microsoft.com/en-us/download/details.aspx?id=48145

更新3(累积更新): https://www.microsoft.com/en-us/download/details.aspx?id=53587

如果您试图在64位项目中运行32位dll，也可能会出现此错误。

当我在x86和x64文件夹中放置相同的文件(32位版本的SQLite.Interop.dll)时，我得到了这个。

超过30个答案，但我用了不同的方法。

我有两个独立的项目。一个Windows服务，和一个Windows窗体应用程序。应用程序引用WS项目，两者都引用SQLite核心nuget包。

在构建WS项目时，有x64和x32文件夹。但在构建应用程序时，文件夹不会显示出来。

检查这里的答案，我不能让他们工作。但是我发现WS项目中有以下代码片段，而App项目中没有。我添加了它，现在文件夹显示正确。

<Import Project="..\packages\System.Data.SQLite.Core.1.0.112.0\build\net46\System.Data.SQLite.Core.targets" Condition="Exists('..\packages\System.Data.SQLite.Core.1.0.112.0\build\net46\System.Data.SQLite.Core.targets')" />

简而言之

为了让它也能与NCrunch一起工作，我必须在NCrunch配置中添加与NuGet包一起提供的Interop.dll版本作为附加文件。

我的情况

我有一个c#解决方案，其中一个项目直接依赖于SQLite(一个帮助库)和一个使用这个帮助库的单元测试项目。我已经安装了System.Data.SQLite.Core版本1.0.97.0作为NuGet包。

在我的案例中，Marin提供的解决方案使它可以在Visual Studio和CI中工作。然而，这仍然会在NCrunch中提供错误。

在NCrunch配置中，我在单元测试项目设置下的“附加文件”中添加了以下路径:

..\packages\System.Data.SQLite.Core.1.0.97.0\build\net45\**.dll

我尝试了几乎所有的解决方案，但没有任何运气。最终解决这个问题的方法是将我选择的平台对应的SQLite.Interop.dll的副本直接放在我的安装项目的根目录下。

我不知道为什么它起作用了，但它确实起了作用。