我在多个项目的解决方案中遇到了类似的问题。SQLite.Interop.dll对于使用ClickOnce随软件发布的一个插件是必要的。

在visual studio中调试一切正常，但是部署的版本缺少包含DLL的文件夹x86/和x64/。

使用ClickOnce让它在部署后工作的解决方案是在解决方案的启动项目(也是正在发布的项目)中创建这两个子文件夹，将dll复制到其中，并将它们设置为Content copy Always。

通过这种方式，ClickOnce发布工具自动将这些文件和文件夹包含在清单中，并使用它们部署软件

扩展Kugel的回答，这对我来说是有效的(VS2015 Enterprise)，利用dll中的SQLite，可以在构建和测试后从主项目中删除Nuget包:

1.安装Nuget包到主项目。

Install-Package System.Data.SQLite

2.构建应用程序并测试Sqlite连接是否正常工作:

select * from sqlite_master

3.从主版本卸载Nuget包。

UnInstall-Package System.Data.SQLite

4.手动删除SQLite和EntityFramework的dll引用:

System.Data.SQLite
System.Data.SQLite.EF6
System.Data.SQLite.Linq

从主项目的“包”中删除Xml引用。配置”XML文件。

这对我来说很有效，使我的项目保持干净。

我有这个问题，因为Visual c++ 2010可重分发没有安装在我的电脑。如果你还没有安装Visual c++ 2010 redistributable，下载并安装这个(检查x86或64 dll)。

我在运行Visual Studio Express 2013时也遇到了同样的问题。我尝试了这里和其他地方提到的几种解决方案，但都没有用。我希望这个修正能帮助到其他人。

我通过在测试基于sqlite的服务的测试类上使用deploymenttem属性来修复它。

例子:

[TestClass]
[DeploymentItem(@"x86\SQLite.Interop.dll", "x86")] // this is the key
public class LocalStoreServiceTests
{

    [TestMethod]
    public void SomeTestThatWasFailing_DueToThisVeryIssue()
    {
         // ... test code here
    }
}

这将导致所需的SQLite.Interop.dll被复制到适当的“TestResults”文件夹中的x86目录。

全是绿色的。一切都很好。

I don't know why this has not been included yet, but I had to do the research and find this out for myself, so hopefully someone will find this answer and be saved the trouble. This was for a WPF app. It worked fine on my Dev box, but did not work on the computer where I was copying it and got the Unable to load DLL 'SQLite.Interop.dll' error. I ported over all of its associated directories and files, directly from my "Debug" folder to this other computer when I got the same error as the OP when I ran it. My "bin" folder that contained my DLLs had been copied to "Debug\bin" and all were included, along with my application files when I did my copying to the other computer using this path, so it was not missing any files.

我在其他答案中看到的不适用的东西:

I did not use the NuGet package or need to create x86 or x64 folders that it seems that NuGet package creates. My DLLs (System.Data.SQLite and SQLite.Interop.dll, along with System.Data.SQLite.config) are in the "bin" folder in my project and were copied in manually (create "bin" folder in Solution Explorer in VS, paste DLLs into this folder in Windows Explorer, use Add > Existing Item to bring files into VS folder/project). Then I reference them as Referenced Assemblies in my project using that location ("References" > "Add Reference", and browse to one, rinse, repeat for the rest). This ensures my project knows exactly where they are. I did not need to reference any SQLite DLL file in my app.config or even touch my MyProject.csproj file. I did not even need to specify a particular processor! My project's build is for "Any CPU", even though I have only mixed or 64-bit DLLs and will only be running on Windows 7+, which are 64-bit OSes. (no x86-only/32-bit solely DLLs) I was already specifying them as "Content" and "copy if newer" for these DLLs when I experienced the OP's error.

我从https://system.data.sqlite.org/index.html/doc/trunk/www/faq.wiki#q20上找到了这个:

(11) Why do I get a DllNotFoundException (for "sqlite3.dll" or "SQLite.Interop.dll") when trying to run my application? Either the named dynamic link library (DLL) cannot be located or it cannot be loaded due to missing dependencies. Make sure the named dynamic link library is located in the application directory or a directory along the system PATH and try again. Also, be sure the necessary Visual C++ runtime redistributable has been installed unless you are using a dynamic link library that was built statically linked to it.

我要强调这段内粗体的部分。目标计算机是新的，除了. net 4.0之外没有加载任何程序。一旦我安装了c++，它就能够完成SQLite的命令。这应该是第一个常见问题之一，也是先决条件的一部分，但它被埋在了第11位。我的开发计算机已经加载了它，因为它带有Visual Studio，所以这就是它在那里工作的原因。

下载: Visual c++ Redistributable for Visual Studio 2015 https://www.microsoft.com/en-us/download/details.aspx?id=48145

更新3(累积更新): https://www.microsoft.com/en-us/download/details.aspx?id=53587

如果您试图在64位项目中运行32位dll，也可能会出现此错误。

当我在x86和x64文件夹中放置相同的文件(32位版本的SQLite.Interop.dll)时，我得到了这个。