Swift 3版本

let _redView = UIView()
        _redView.backgroundColor = UIColor.red
        _redView.translatesAutoresizingMaskIntoConstraints = false

        let _yellowView = UIView()
        _yellowView.backgroundColor = UIColor.yellow
        _yellowView.translatesAutoresizingMaskIntoConstraints = false

        let _blueView = UIView()
        _blueView.backgroundColor = UIColor.blue
        _blueView.translatesAutoresizingMaskIntoConstraints = false

        self.view.addSubview(_redView)
        self.view.addSubview(_yellowView)
        self.view.addSubview(_blueView)

        var views = ["_redView": _redView, "_yellowView": _yellowView, "_blueView":_blueView]

        var nslayoutConstraint_H = NSLayoutConstraint.constraints(withVisualFormat: "|->=0-[_redView(40)]->=0-[_yellowView(40)]->=0-[_blueView(40)]->=0-|", options: [.alignAllTop, .alignAllBottom], metrics: nil, views: views)
        self.view.addConstraints(nslayoutConstraint_H)

        var nslayoutConstraint_V = NSLayoutConstraint.constraints(withVisualFormat: "V:[_redView(60)]", options: NSLayoutFormatOptions.init(rawValue: 0), metrics: nil, views: views)
        self.view.addConstraints(nslayoutConstraint_V)


        let constraint_red = NSLayoutConstraint.init(item: self.view, attribute: .centerY, relatedBy: .equal, toItem: _redView, attribute: .centerY, multiplier: 1, constant: 0)
        self.view.addConstraint(constraint_red)

        let constraint_yellow = NSLayoutConstraint.init(item: self.view, attribute: .centerX, relatedBy: .equal, toItem: _yellowView, attribute: .centerX, multiplier: 1, constant: 0)
        self.view.addConstraint(constraint_yellow)

        let constraint_yellow1 = NSLayoutConstraint.init(item: _redView, attribute: .centerX, relatedBy: .equal, toItem: _yellowView, attribute: .leading, multiplier: 0.5, constant: 0)
        self.view.addConstraint(constraint_yellow1)

        let constraint_yellow2 = NSLayoutConstraint.init(item: _blueView, attribute: .centerX, relatedBy: .equal, toItem: _yellowView, attribute: .leading, multiplier: 1.5, constant: 40)
        self.view.addConstraint(constraint_yellow2)

查看https://developer.apple.com/library/ios/documentation/UserExperience/Conceptual/AutolayoutPG/AutoLayoutbyExample/AutoLayoutbyExample.html，上面有关于解决问题的详细描述。

基于Ben Dolman的回答，这将更均匀地分配视图(使用填充等):

+(NSArray *)constraintsForEvenDistributionOfItems:(NSArray *)views
                           relativeToCenterOfItem:(id)toView vertically:(BOOL)vertically
{
    NSMutableArray *constraints = [NSMutableArray new];
    NSLayoutAttribute attr = vertically ? NSLayoutAttributeCenterY : NSLayoutAttributeCenterX;

    CGFloat min = 0.25;
    CGFloat max = 1.75;
    CGFloat d = (max-min) / ([views count] - 1);
    for (NSUInteger i = 0; i < [views count]; i++) {
        id view = views[i];
        CGFloat multiplier = i * d + min;
        NSLayoutConstraint *constraint = [NSLayoutConstraint constraintWithItem:view
                                                                      attribute:attr
                                                                      relatedBy:NSLayoutRelationEqual
                                                                         toItem:toView
                                                                      attribute:attr
                                                                     multiplier:multiplier
                                                                       constant:0];
        [constraints addObject:constraint];
    }

    return constraints;
}

这里还有另一个答案。我在回答一个类似的问题时看到了这个问题的链接。我没有看到任何与我类似的答案。所以我想写在这里。

  class ViewController: UIViewController {

    override func viewDidLoad() {
        super.viewDidLoad()
        view.backgroundColor = UIColor.whiteColor()
        setupViews()
    }

    var constraints: [NSLayoutConstraint] = []

    func setupViews() {

        let container1 = createButtonContainer(withButtonTitle: "Button 1")
        let container2 = createButtonContainer(withButtonTitle: "Button 2")
        let container3 = createButtonContainer(withButtonTitle: "Button 3")
        let container4 = createButtonContainer(withButtonTitle: "Button 4")

        view.addSubview(container1)
        view.addSubview(container2)
        view.addSubview(container3)
        view.addSubview(container4)

        [

            // left right alignment
            container1.leftAnchor.constraintEqualToAnchor(view.leftAnchor, constant: 20),
            container1.rightAnchor.constraintEqualToAnchor(view.rightAnchor, constant: -20),
            container2.leftAnchor.constraintEqualToAnchor(container1.leftAnchor),
            container2.rightAnchor.constraintEqualToAnchor(container1.rightAnchor),
            container3.leftAnchor.constraintEqualToAnchor(container1.leftAnchor),
            container3.rightAnchor.constraintEqualToAnchor(container1.rightAnchor),
            container4.leftAnchor.constraintEqualToAnchor(container1.leftAnchor),
            container4.rightAnchor.constraintEqualToAnchor(container1.rightAnchor),


            // place containers one after another vertically
            container1.topAnchor.constraintEqualToAnchor(view.topAnchor),
            container2.topAnchor.constraintEqualToAnchor(container1.bottomAnchor),
            container3.topAnchor.constraintEqualToAnchor(container2.bottomAnchor),
            container4.topAnchor.constraintEqualToAnchor(container3.bottomAnchor),
            container4.bottomAnchor.constraintEqualToAnchor(view.bottomAnchor),


            // container height constraints
            container2.heightAnchor.constraintEqualToAnchor(container1.heightAnchor),
            container3.heightAnchor.constraintEqualToAnchor(container1.heightAnchor),
            container4.heightAnchor.constraintEqualToAnchor(container1.heightAnchor)
            ]
            .forEach { $0.active = true }
    }


    func createButtonContainer(withButtonTitle title: String) -> UIView {
        let view = UIView(frame: .zero)
        view.translatesAutoresizingMaskIntoConstraints = false

        let button = UIButton(type: .System)
        button.translatesAutoresizingMaskIntoConstraints = false
        button.setTitle(title, forState: .Normal)
        view.addSubview(button)

        [button.centerYAnchor.constraintEqualToAnchor(view.centerYAnchor),
            button.leftAnchor.constraintEqualToAnchor(view.leftAnchor),
            button.rightAnchor.constraintEqualToAnchor(view.rightAnchor)].forEach { $0.active = true }

        return view
    }
}

同样，这也可以用iOS9 UIStackViews很容易做到。

class ViewController: UIViewController {

    override func viewDidLoad() {
        super.viewDidLoad()
        view.backgroundColor = UIColor.greenColor()
        setupViews()
    }

    var constraints: [NSLayoutConstraint] = []

    func setupViews() {

        let container1 = createButtonContainer(withButtonTitle: "Button 1")
        let container2 = createButtonContainer(withButtonTitle: "Button 2")
        let container3 = createButtonContainer(withButtonTitle: "Button 3")
        let container4 = createButtonContainer(withButtonTitle: "Button 4")

        let stackView = UIStackView(arrangedSubviews: [container1, container2, container3, container4])
        stackView.translatesAutoresizingMaskIntoConstraints = false
        stackView.axis = .Vertical
        stackView.distribution = .FillEqually
        view.addSubview(stackView)

        [stackView.topAnchor.constraintEqualToAnchor(view.topAnchor),
            stackView.bottomAnchor.constraintEqualToAnchor(view.bottomAnchor),
            stackView.leftAnchor.constraintEqualToAnchor(view.leftAnchor, constant: 20),
            stackView.rightAnchor.constraintEqualToAnchor(view.rightAnchor, constant: -20)].forEach { $0.active = true }
    }


    func createButtonContainer(withButtonTitle title: String) -> UIView {
        let button = UIButton(type: .Custom)
        button.translatesAutoresizingMaskIntoConstraints = false
        button.backgroundColor = UIColor.redColor()
        button.setTitleColor(UIColor.whiteColor(), forState: .Normal)
        button.setTitle(title, forState: .Normal)
        let buttonContainer = UIStackView(arrangedSubviews: [button])
        buttonContainer.distribution = .EqualCentering
        buttonContainer.alignment = .Center
        buttonContainer.translatesAutoresizingMaskIntoConstraints = false
        return buttonContainer
    }
}

注意，这与上面的方法完全相同。它添加了四个容器视图，这些视图都是均等填充的，每个堆栈视图都添加了一个视图，并在中间对齐。但是，这个版本的UIStackView减少了一些代码，看起来不错。

在iOS 9中，苹果通过(期待已久的)UIStackView使这变得非常容易。只需选择要包含在接口构建器中的视图，并选择编辑器->嵌入->堆栈视图。为堆栈视图设置适当的宽度/高度/边距约束，并确保将Distribution属性设置为'Equal spacing':

当然，如果你需要支持iOS 8或更低版本，你必须从其他选项中选择一个。

我找到了一个完美而简单的方法。自动布局不允许你平等地调整空间大小，但它允许你平等地调整视图大小。简单地在你的字段之间放置一些不可见的视图，并告诉自动布局保持它们相同的大小。它工作得很完美!

但有一件事值得注意;当我在界面设计器中减小尺寸时，有时它会混淆，在原来的地方留下一个标签，如果大小改变了奇数个量，它就会发生冲突。除此之外，它工作得很完美。

编辑:我发现冲突成了一个问题。因此，我删除了其中一个间距约束，并将其替换为两个约束，一个大于或等于，一个小于或等于。两者的大小相同，优先级比其他约束低得多。结果没有进一步的冲突。