使用正则表达式验证器:

<asp:TextBox ID="TextBoxNum" runat="server"></asp:TextBox><br />
<asp:RegularExpressionValidator ID="RegularExpressionValidator1"
                        ControlToValidate="TextBoxNum" runat="server"
                        ErrorMessage="Only numbers allowed"
                        ValidationExpression="\d+">
</asp:RegularExpressionValidator>

我会在KeyDown事件中处理它。

void TextBox_KeyDown(object sender, KeyEventArgs e)
        {
            char c = Convert.ToChar(e.PlatformKeyCode);
            if (!char.IsDigit(c))
            {
                e.Handled = true;
            }
        }

我也在寻找最好的方法来检查文本框中只有数字和键盘的问题是，它不支持通过右键单击或剪贴板复制粘贴，所以提出了这个代码，验证光标离开文本字段时，它也检查空字段。(newguy改编版)

private void txtFirstValue_MouseLeave(object sender, EventArgs e)
{
    int num;
    bool isNum = int.TryParse(txtFirstValue.Text.Trim(), out num);

    if (!isNum && txtFirstValue.Text != String.Empty)
    {
        MessageBox.Show("The First Value You Entered Is Not a Number, Please Try Again", "Invalid Value Detected", MessageBoxButtons.OK, MessageBoxIcon.Error);
        txtFirstValue.Clear();
    }
}

WPF的工作解决方案&一个简单的TextChangedEventArgs。

private void TextBox_TextChanged(object sender, TextChangedEventArgs e)
{
    var TextBox = (sender as TextBox);

    // if not a numeric value, remove news characters
    if (Regex.IsMatch(TextBox.Text, "[^0-9]"))
    {
        foreach (TextChange Change in e.Changes)
        {
            TextBox.Text = TextBox.Text.Remove(Change.Offset, Change.AddedLength);

            TextBox.CaretIndex = Change.Offset;
        }
    }
}

不要忘记用户可以在文本框中粘贴无效文本。

如果你想限制它，遵循下面的代码:

private void ultraTextEditor1_TextChanged(object sender, EventArgs e)
{
    string append="";
    foreach (char c in ultraTextEditor1.Text)
    {
        if ((!Char.IsNumber(c)) && (c != Convert.ToChar(Keys.Back)))
        {

        }
        else
        {
            append += c;
        }
    }

    ultraTextEditor1.Text = append;
}   

这可能有用。它允许“真实”数值，包括正确的小数点和前面的加号或减号。从相关的KeyPress事件中调用它。

       private bool IsOKForDecimalTextBox(char theCharacter, TextBox theTextBox)
    {
        // Only allow control characters, digits, plus and minus signs.
        // Only allow ONE plus sign.
        // Only allow ONE minus sign.
        // Only allow the plus or minus sign as the FIRST character.
        // Only allow ONE decimal point.
        // Do NOT allow decimal point or digits BEFORE any plus or minus sign.

        if (
            !char.IsControl(theCharacter)
            && !char.IsDigit(theCharacter)
            && (theCharacter != '.')
            && (theCharacter != '-')
            && (theCharacter != '+')
        )
        {
            // Then it is NOT a character we want allowed in the text box.
            return false;
        }



        // Only allow one decimal point.
        if (theCharacter == '.'
            && theTextBox.Text.IndexOf('.') > -1)
        {
            // Then there is already a decimal point in the text box.
            return false;
        }

        // Only allow one minus sign.
        if (theCharacter == '-'
            && theTextBox.Text.IndexOf('-') > -1)
        {
            // Then there is already a minus sign in the text box.
            return false;
        }

        // Only allow one plus sign.
        if (theCharacter == '+'
            && theTextBox.Text.IndexOf('+') > -1)
        {
            // Then there is already a plus sign in the text box.
            return false;
        }

        // Only allow one plus sign OR minus sign, but not both.
        if (
            (
                (theCharacter == '-')
                || (theCharacter == '+')
            )
            && 
            (
                (theTextBox.Text.IndexOf('-') > -1)
                ||
                (theTextBox.Text.IndexOf('+') > -1)
            )
            )
        {
            // Then the user is trying to enter a plus or minus sign and
            // there is ALREADY a plus or minus sign in the text box.
            return false;
        }

        // Only allow a minus or plus sign at the first character position.
        if (
            (
                (theCharacter == '-')
                || (theCharacter == '+')
            )
            && theTextBox.SelectionStart != 0
            )
        {
            // Then the user is trying to enter a minus or plus sign at some position 
            // OTHER than the first character position in the text box.
            return false;
        }

        // Only allow digits and decimal point AFTER any existing plus or minus sign
        if  (
                (
                    // Is digit or decimal point
                    char.IsDigit(theCharacter)
                    ||
                    (theCharacter == '.')
                )
                &&
                (
                    // A plus or minus sign EXISTS
                    (theTextBox.Text.IndexOf('-') > -1)
                    ||
                    (theTextBox.Text.IndexOf('+') > -1)
                )
                &&
                    // Attempting to put the character at the beginning of the field.
                    theTextBox.SelectionStart == 0
            )
        {
            // Then the user is trying to enter a digit or decimal point in front of a minus or plus sign.
            return false;
        }

        // Otherwise the character is perfectly fine for a decimal value and the character
        // may indeed be placed at the current insertion position.
        return true;
    }