# FIRST METHOD
# Storing all punctuations in a variable    
punctuation='!?,.:;"\')(_-'
newstring ='' # Creating empty string
word = raw_input("Enter string: ")
for i in word:
     if(i not in punctuation):
                  newstring += i
print ("The string without punctuation is", newstring)

# SECOND METHOD
word = raw_input("Enter string: ")
punctuation = '!?,.:;"\')(_-'
newstring = word.translate(None, punctuation)
print ("The string without punctuation is",newstring)


# Output for both methods
Enter string: hello! welcome -to_python(programming.language)??,
The string without punctuation is: hello welcome topythonprogramminglanguage

考虑unicode。代码已在python3中检查。

from unicodedata import category
text = 'hi, how are you?'
text_without_punc = ''.join(ch for ch in text if not category(ch).startswith('P'))

我还没有看到这个答案。只需使用正则表达式；它删除了除单词字符（\w）和数字字符（\d）之外的所有字符，后跟一个空白字符（\s）：

import re
s = "string. With. Punctuation?" # Sample string 
out = re.sub(ur'[^\w\d\s]+', '', s)

with open('one.txt','r')as myFile:

    str1=myFile.read()

    print(str1)


    punctuation = ['(', ')', '?', ':', ';', ',', '.', '!', '/', '"', "'"] 

for i in punctuation:

        str1 = str1.replace(i," ") 
        myList=[]
        myList.extend(str1.split(" "))
print (str1) 
for i in myList:

    print(i,end='\n')
    print ("____________")

字符串标点符号仅为ASCII！一种更正确（但也慢得多）的方法是使用unicodedata模块：

# -*- coding: utf-8 -*-
from unicodedata import category
s = u'String — with -  «punctation »...'
s = ''.join(ch for ch in s if category(ch)[0] != 'P')
print 'stripped', s

您还可以概括和剥离其他类型的字符：

''.join(ch for ch in s if category(ch)[0] not in 'SP')

它还将删除~*+§$等字符，这些字符可能是“标点符号”，也可能不是“标点符号。

不一定更简单，但如果你更熟悉re家族的话，就另辟蹊径。

import re, string
s = "string. With. Punctuation?" # Sample string 
out = re.sub('[%s]' % re.escape(string.punctuation), '', s)