显然，我无法对所选答案进行编辑，所以这里有一个适用于Python3的更新。在进行非平凡转换时，转换方法仍然是最有效的选择。

上面的@Brian为最初的繁重工作做出了贡献。感谢@ddejohn对原始测试的改进建议。

#!/usr/bin/env python3

"""Determination of most efficient way to remove punctuation in Python 3.

Results in Python 3.8.10 on my system using the default arguments:

set       : 51.897
regex     : 17.901
translate :  2.059
replace   : 13.209
"""

import argparse
import re
import string
import timeit

parser = argparse.ArgumentParser()
parser.add_argument("--filename", "-f", default=argparse.__file__)
parser.add_argument("--iterations", "-i", type=int, default=10000)
opts = parser.parse_args()
with open(opts.filename) as fp:
    s = fp.read()
exclude = set(string.punctuation)
table = str.maketrans("", "", string.punctuation)
regex = re.compile(f"[{re.escape(string.punctuation)}]")

def test_set(s):
    return "".join(ch for ch in s if ch not in exclude)

def test_regex(s):  # From Vinko's solution, with fix.
    return regex.sub("", s)

def test_translate(s):
    return s.translate(table)

def test_replace(s):  # From S.Lott's solution
    for c in string.punctuation:
        s = s.replace(c, "")
    return s

opts = dict(globals=globals(), number=opts.iterations)
solutions = "set", "regex", "translate", "replace"
for solution in solutions:
    elapsed = timeit.timeit(f"test_{solution}(s)", **opts)
    print(f"{solution:<10}: {elapsed:6.3f}")

为什么你们都不用这个？

 ''.join(filter(str.isalnum, s)) 

太慢了？

# FIRST METHOD
# Storing all punctuations in a variable    
punctuation='!?,.:;"\')(_-'
newstring ='' # Creating empty string
word = raw_input("Enter string: ")
for i in word:
     if(i not in punctuation):
                  newstring += i
print ("The string without punctuation is", newstring)

# SECOND METHOD
word = raw_input("Enter string: ")
punctuation = '!?,.:;"\')(_-'
newstring = word.translate(None, punctuation)
print ("The string without punctuation is",newstring)


# Output for both methods
Enter string: hello! welcome -to_python(programming.language)??,
The string without punctuation is: hello welcome topythonprogramminglanguage

作为更新，我重写了Python 3中的@Brian示例，并对其进行了更改，以将正则表达式编译步骤移到函数内部。我在这里的想法是对使功能工作所需的每一步进行计时。也许您使用的是分布式计算，无法在工作人员之间共享regex对象，需要在每个工作人员处执行re.compile步骤。此外，我还很好奇地对Python 3的maketrans的两种不同实现进行计时

table = str.maketrans({key: None for key in string.punctuation})

vs

table = str.maketrans('', '', string.punctuation)

另外，我添加了另一种使用集合的方法，在这里我利用交集函数来减少迭代次数。

这是完整的代码：

import re, string, timeit

s = "string. With. Punctuation"


def test_set(s):
    exclude = set(string.punctuation)
    return ''.join(ch for ch in s if ch not in exclude)


def test_set2(s):
    _punctuation = set(string.punctuation)
    for punct in set(s).intersection(_punctuation):
        s = s.replace(punct, ' ')
    return ' '.join(s.split())


def test_re(s):  # From Vinko's solution, with fix.
    regex = re.compile('[%s]' % re.escape(string.punctuation))
    return regex.sub('', s)


def test_trans(s):
    table = str.maketrans({key: None for key in string.punctuation})
    return s.translate(table)


def test_trans2(s):
    table = str.maketrans('', '', string.punctuation)
    return(s.translate(table))


def test_repl(s):  # From S.Lott's solution
    for c in string.punctuation:
        s=s.replace(c,"")
    return s


print("sets      :",timeit.Timer('f(s)', 'from __main__ import s,test_set as f').timeit(1000000))
print("sets2      :",timeit.Timer('f(s)', 'from __main__ import s,test_set2 as f').timeit(1000000))
print("regex     :",timeit.Timer('f(s)', 'from __main__ import s,test_re as f').timeit(1000000))
print("translate :",timeit.Timer('f(s)', 'from __main__ import s,test_trans as f').timeit(1000000))
print("translate2 :",timeit.Timer('f(s)', 'from __main__ import s,test_trans2 as f').timeit(1000000))
print("replace   :",timeit.Timer('f(s)', 'from __main__ import s,test_repl as f').timeit(1000000))

这是我的结果：

sets      : 3.1830138750374317
sets2      : 2.189873124472797
regex     : 7.142953420989215
translate : 4.243278483860195
translate2 : 2.427158243022859
replace   : 4.579746678471565

从效率的角度来看，你不会击败

s.translate(None, string.punctuation)

对于更高版本的Python，请使用以下代码：

s.translate(str.maketrans('', '', string.punctuation))

它使用查找表在C语言中执行原始字符串操作——除了编写自己的C代码之外，没有什么能比这更好的了。

如果速度不令人担忧，另一个选择是：

exclude = set(string.punctuation)
s = ''.join(ch for ch in s if ch not in exclude)

这比用每个字符替换s.replace更快，但不会像正则表达式或字符串转换等非纯python方法那样执行得好，正如您从下面的计时中看到的那样。对于这种类型的问题，在尽可能低的水平上解决是有回报的。

计时代码：

import re, string, timeit

s = "string. With. Punctuation"
exclude = set(string.punctuation)
table = string.maketrans("","")
regex = re.compile('[%s]' % re.escape(string.punctuation))

def test_set(s):
    return ''.join(ch for ch in s if ch not in exclude)

def test_re(s):  # From Vinko's solution, with fix.
    return regex.sub('', s)

def test_trans(s):
    return s.translate(table, string.punctuation)

def test_repl(s):  # From S.Lott's solution
    for c in string.punctuation:
        s=s.replace(c,"")
    return s

print "sets      :",timeit.Timer('f(s)', 'from __main__ import s,test_set as f').timeit(1000000)
print "regex     :",timeit.Timer('f(s)', 'from __main__ import s,test_re as f').timeit(1000000)
print "translate :",timeit.Timer('f(s)', 'from __main__ import s,test_trans as f').timeit(1000000)
print "replace   :",timeit.Timer('f(s)', 'from __main__ import s,test_repl as f').timeit(1000000)

结果如下：

sets      : 19.8566138744
regex     : 6.86155414581
translate : 2.12455511093
replace   : 28.4436721802

为了方便使用，我总结了Python 2和Python 3中从字符串中删除标点符号的注意事项。有关详细说明，请参阅其他答案。

Python 2

import string

s = "string. With. Punctuation?"
table = string.maketrans("","")
new_s = s.translate(table, string.punctuation)      # Output: string without punctuation

Python 3

import string

s = "string. With. Punctuation?"
table = str.maketrans(dict.fromkeys(string.punctuation))  # OR {key: None for key in string.punctuation}
new_s = s.translate(table)                          # Output: string without punctuation