我在寻找一个非常简单的解决方案。这是我得到的：

import re 

s = "string. With. Punctuation?" 
s = re.sub(r'[\W\s]', ' ', s)

print(s)
'string  With  Punctuation '

# FIRST METHOD
# Storing all punctuations in a variable    
punctuation='!?,.:;"\')(_-'
newstring ='' # Creating empty string
word = raw_input("Enter string: ")
for i in word:
     if(i not in punctuation):
                  newstring += i
print ("The string without punctuation is", newstring)

# SECOND METHOD
word = raw_input("Enter string: ")
punctuation = '!?,.:;"\')(_-'
newstring = word.translate(None, punctuation)
print ("The string without punctuation is",newstring)


# Output for both methods
Enter string: hello! welcome -to_python(programming.language)??,
The string without punctuation is: hello welcome topythonprogramminglanguage

我通常用这样的词：

>>> s = "string. With. Punctuation?" # Sample string
>>> import string
>>> for c in string.punctuation:
...     s= s.replace(c,"")
...
>>> s
'string With Punctuation'

这可能不是最好的解决方案，但我就是这样做的。

import string
f = lambda x: ''.join([i for i in x if i not in string.punctuation])

从效率的角度来看，你不会击败

s.translate(None, string.punctuation)

对于更高版本的Python，请使用以下代码：

s.translate(str.maketrans('', '', string.punctuation))

它使用查找表在C语言中执行原始字符串操作——除了编写自己的C代码之外，没有什么能比这更好的了。

如果速度不令人担忧，另一个选择是：

exclude = set(string.punctuation)
s = ''.join(ch for ch in s if ch not in exclude)

这比用每个字符替换s.replace更快，但不会像正则表达式或字符串转换等非纯python方法那样执行得好，正如您从下面的计时中看到的那样。对于这种类型的问题，在尽可能低的水平上解决是有回报的。

计时代码：

import re, string, timeit

s = "string. With. Punctuation"
exclude = set(string.punctuation)
table = string.maketrans("","")
regex = re.compile('[%s]' % re.escape(string.punctuation))

def test_set(s):
    return ''.join(ch for ch in s if ch not in exclude)

def test_re(s):  # From Vinko's solution, with fix.
    return regex.sub('', s)

def test_trans(s):
    return s.translate(table, string.punctuation)

def test_repl(s):  # From S.Lott's solution
    for c in string.punctuation:
        s=s.replace(c,"")
    return s

print "sets      :",timeit.Timer('f(s)', 'from __main__ import s,test_set as f').timeit(1000000)
print "regex     :",timeit.Timer('f(s)', 'from __main__ import s,test_re as f').timeit(1000000)
print "translate :",timeit.Timer('f(s)', 'from __main__ import s,test_trans as f').timeit(1000000)
print "replace   :",timeit.Timer('f(s)', 'from __main__ import s,test_repl as f').timeit(1000000)

结果如下：

sets      : 19.8566138744
regex     : 6.86155414581
translate : 2.12455511093
replace   : 28.4436721802

下面是Python 3.5的一行代码：

import string
"l*ots! o(f. p@u)n[c}t]u[a'ti\"on#$^?/".translate(str.maketrans({a:None for a in string.punctuation}))