myString.translate(None, string.punctuation)

不一定更简单，但如果你更熟悉re家族的话，就另辟蹊径。

import re, string
s = "string. With. Punctuation?" # Sample string 
out = re.sub('[%s]' % re.escape(string.punctuation), '', s)

试试那个：）

regex.sub(r'\p{P}','', s)

这里有一个没有正则表达式的解决方案。

import string

input_text = "!where??and!!or$$then:)"
punctuation_replacer = string.maketrans(string.punctuation, ' '*len(string.punctuation))    
print ' '.join(input_text.translate(punctuation_replacer).split()).strip()

Output>> where and or then

用空格替换标点用单个空格替换单词之间的多个空格删除尾随空格（如果有）条带（）

# FIRST METHOD
# Storing all punctuations in a variable    
punctuation='!?,.:;"\')(_-'
newstring ='' # Creating empty string
word = raw_input("Enter string: ")
for i in word:
     if(i not in punctuation):
                  newstring += i
print ("The string without punctuation is", newstring)

# SECOND METHOD
word = raw_input("Enter string: ")
punctuation = '!?,.:;"\')(_-'
newstring = word.translate(None, punctuation)
print ("The string without punctuation is",newstring)


# Output for both methods
Enter string: hello! welcome -to_python(programming.language)??,
The string without punctuation is: hello welcome topythonprogramminglanguage

下面是Python 3.5的一行代码：

import string
"l*ots! o(f. p@u)n[c}t]u[a'ti\"on#$^?/".translate(str.maketrans({a:None for a in string.punctuation}))