转到“项目属性”，在“构建”下确保“优化代码”复选框未选中。

此外，在高级选项(在构建选项卡下)中将“调试信息”下拉菜单设置为“完全”。

我也遇到过同样的问题，我的解决方案是将解决方案配置从发布更改为调试。希望能有所帮助

关于“优化代码”属性未选中的问题，但代码仍然编译为优化:在尝试了所有东西后，最后帮助我的是在同一设置页面上检查“启用非托管代码调试”复选框(项目属性-调试)。它与代码优化没有直接关系，但是启用这个功能后，VS不再优化我的库，我可以调试。

I found that I had the same problem when I was running a project and debugging by attaching to an IIS process. I also was running in Debug mode with optimizations turned off. While I thought the code compiled fine, when I detached and tried to compile, one of the references was not found. This was due to another developer here that made modifications and changed the location of the reference. The reference did not show up with the alert symbol, so I thought everything was fine until I did the compilation. Once fixing the reference and running again it worked.

检查您的AssemblyInfo文件中是否有Debuggable属性。如果存在，则删除它并重新构建解决方案，以查看本地变量是否可用。

我的可调试属性被设置为:DebuggableAttribute.DebuggingModes.IgnoreSymbolStoreSequencePoints，根据这篇MSDN文章，它告诉JIT编译器使用优化。我从我的AssemblyInfo.cs文件中删除了这一行，本地变量就可用了。

在Visual Studio 2012中:

打开项目属性->调试->取消选中“启用Visual Studio托管进程”