我在这个游戏中有点晚了，但你可以做一个性能的比较，上面提到的一些代码和这个，两个最快的竞争者是，

list(set(x).symmetric_difference(set(y)))
list(set(x) ^ set(y))

我为我的初级编码水平道歉。

import time
import random
from itertools import filterfalse

# 1 - performance (time taken)
# 2 - correctness (answer - 1,4,5,6)
# set performance
performance = 1
numberoftests = 7

def answer(x,y,z):
    if z == 0:
        start = time.clock()
        lists = (str(list(set(x)-set(y))+list(set(y)-set(y))))
        times = ("1 = " + str(time.clock() - start))
        return (lists,times)

    elif z == 1:
        start = time.clock()
        lists = (str(list(set(x).symmetric_difference(set(y)))))
        times = ("2 = " + str(time.clock() - start))
        return (lists,times)

    elif z == 2:
        start = time.clock()
        lists = (str(list(set(x) ^ set(y))))
        times = ("3 = " + str(time.clock() - start))
        return (lists,times)

    elif z == 3:
        start = time.clock()
        lists = (filterfalse(set(y).__contains__, x))
        times = ("4 = " + str(time.clock() - start))
        return (lists,times)

    elif z == 4:
        start = time.clock()
        lists = (tuple(set(x) - set(y)))
        times = ("5 = " + str(time.clock() - start))
        return (lists,times)

    elif z == 5:
        start = time.clock()
        lists = ([tt for tt in x if tt not in y])
        times = ("6 = " + str(time.clock() - start))
        return (lists,times)

    else:    
        start = time.clock()
        Xarray = [iDa for iDa in x if iDa not in y]
        Yarray = [iDb for iDb in y if iDb not in x]
        lists = (str(Xarray + Yarray))
        times = ("7 = " + str(time.clock() - start))
        return (lists,times)

n = numberoftests

if performance == 2:
    a = [1,2,3,4,5]
    b = [3,2,6]
    for c in range(0,n):
        d = answer(a,b,c)
        print(d[0])

elif performance == 1:
    for tests in range(0,10):
        print("Test Number" + str(tests + 1))
        a = random.sample(range(1, 900000), 9999)
        b = random.sample(range(1, 900000), 9999)
        for c in range(0,n):
            #if c not in (1,4,5,6):
            d = answer(a,b,c)
            print(d[1])

下面是@arkolec的回答，下面是一个用于比较列表、元组和集的实用程序类:

from difflib import SequenceMatcher

class ListDiffer:

    def __init__(self, left, right, strict:bool=False):
        assert isinstance(left, (list, tuple, set)), "left must be list, tuple or set"
        assert isinstance(right, (list, tuple, set)), "right must be list, tuple or set"
        self.l = list(left) if isinstance(left, (tuple, set)) else left
        self.r = list(right) if isinstance(left, (tuple, set)) else right

        if strict:
            assert isinstance(left, right.__class__), \
                f'left type ({left.__class__.__name__}) must equal right type ({right.__class__.__name__})'

        self.diffs = []
        self.equal = []

        for tag, i, j, k, l in SequenceMatcher(None, self.l, self.r).get_opcodes():
            if tag in ['delete', 'replace', 'insert']:
                self.diffs.append((tag, i, j, k, l))
            elif tag == 'equal':
                [self.equal.append(v) for v in left[i:j]]
                


    def has_diffs(self):
        return len(self.diffs) > 0


    def only_left(self):
        a = self.l[:]
        [a.remove(v) for v in self.equal]
        return a

    def only_right(self):
        a = self.r[:]
        [a.remove(v) for v in self.equal]
        return a


    def __str__(self, verbose:bool=False):
        iD = 0
        sb = []
        if verbose:
            sb.append(f"left: {self.l}\n")
            sb.append(f"right: {self.r}\n")
            sb.append(f"diffs: ")
        for tag, i, j, k, l in self.diffs:
            s = f"({iD})"
            if iD > 0: sb.append(' | ')
            if tag in ('delete', 'replace'): s = f'{s} l:{self.l[i:j]}'
            if tag in ('insert', 'replace'): s = f'{s} r:{self.r[k:l]}'
            sb.append(s)
            iD = iD + 1

        if verbose:
            sb.append(f"\nequal: {self.equal}")
        return ''.join(sb)

    def __repr__(self) -> str:
        return "<ListDiffer> {}".format(self.__str__())

用法:

left = ['a','b','c']
right = ['aa','b','c','d']
# right = ('aa','b','c','d')
ld = ListDiffer(left, right, strict=True)
print(f'ld.has_diffs(): {ld.has_diffs()}')
print(f'ld: {ld}')
print(f'ld.only_left(): {ld.only_left()}')
print(f'ld.only_right(): {ld.only_right()}')

输出:

ld.has_diffs(): True
ld: (0) l:['a'] r:['aa'] | (1) r:['d']
ld.only_left(): ['a']
ld.only_right(): ['aa', 'd']

我不能说性能，但你可以使用ld.only_left()来获得你正在寻找的结果。

我们可以计算交集减去列表并集:

temp1 = ['One', 'Two', 'Three', 'Four']
temp2 = ['One', 'Two', 'Five']

set(temp1+temp2)-(set(temp1)&set(temp2))

Out: set(['Four', 'Five', 'Three']) 

这里有一个最简单情况的反答案。

这比上面那个做双向差分的要短，因为它只做了问题要求的事情:生成第一个列表中的东西的列表，而不是第二个列表中的东西。

from collections import Counter

lst1 = ['One', 'Two', 'Three', 'Four']
lst2 = ['One', 'Two']

c1 = Counter(lst1)
c2 = Counter(lst2)
diff = list((c1 - c2).elements())

或者，根据你的可读性偏好，它可以是一个不错的单行代码:

diff = list((Counter(lst1) - Counter(lst2)).elements())

输出:

['Three', 'Four']

请注意，如果您只是对其进行迭代，则可以删除list(…)调用。

因为这个解决方案使用计数器，所以相对于许多基于集合的答案，它可以正确地处理数量。例如，在这个输入中:

lst1 = ['One', 'Two', 'Two', 'Two', 'Three', 'Three', 'Four']
lst2 = ['One', 'Two']

输出结果为:

['Two', 'Two', 'Three', 'Three', 'Four']

我知道这个问题已经得到了很好的答案，但我希望使用numpy添加以下方法。

temp1 = ['One', 'Two', 'Three', 'Four']
temp2 = ['One', 'Two']

list(np.setdiff1d(temp1,temp2))

['Four', 'Three'] #Output

由于目前的解决方案都不产生一个元组，我将抛出:

temp3 = tuple(set(temp1) - set(temp2))

另外:

#edited using @Mark Byers idea. If you accept this one as answer, just accept his instead.
temp3 = tuple(x for x in temp1 if x not in set(temp2))

像其他在这个方向上得到答案的非元组一样，它保持了顺序