我的解决方案是直接使用反射来创建序列化器。这就绕过了导致异常的奇怪文件加载。我将其打包在一个helper函数中，该函数还负责缓存序列化器。

private static readonly Dictionary<Type,XmlSerializer> _xmlSerializerCache = new Dictionary<Type, XmlSerializer>();

public static XmlSerializer CreateDefaultXmlSerializer(Type type) 
{
    XmlSerializer serializer;
    if (_xmlSerializerCache.TryGetValue(type, out serializer))
    {
        return serializer;
    }
    else
    {
        var importer = new XmlReflectionImporter();
        var mapping = importer.ImportTypeMapping(type, null, null);
        serializer = new XmlSerializer(mapping);
        return _xmlSerializerCache[type] = serializer;
    }
}

只是作为参考。从D-B的回答和评论中，我得出了这个接近D-B的解决方案。它在我的所有情况下都工作得很好，并且是线程安全的。我不认为使用ConcurrentDictionary是可以的。

using System;
using System.Collections.Generic;
using System.Xml.Serialization;

namespace HQ.Util.General
{
    public class XmlSerializerHelper
    {
        private static readonly Dictionary<Type, XmlSerializer> _dictTypeToSerializer = new Dictionary<Type, XmlSerializer>();

        public static XmlSerializer GetSerializer(Type type)
        {
            lock (_dictTypeToSerializer)
            {
                XmlSerializer serializer;
                if (! _dictTypeToSerializer.TryGetValue(type, out serializer))
                {
                    var importer = new XmlReflectionImporter();
                    var mapping = importer.ImportTypeMapping(type, null, null);
                    serializer = new XmlSerializer(mapping);
                    return _dictTypeToSerializer[type] = serializer;
                }

                return serializer;
            }
        }
    }
}

用法:

        if (File.Exists(Path))
        {
            using (XmlTextReader reader = new XmlTextReader(Path))
            {
                // XmlSerializer x  = new XmlSerializer(typeof(T));
                var x = XmlSerializerHelper.GetSerializer(typeof(T));

                try
                {
                    options = (OptionsBase<T>)x.Deserialize(reader);
                }
                catch (Exception ex)
                {
                    Log.Instance.AddEntry(LogType.LogException, "Unable to open Options file: " + Path, ex);
                }
            }
        }

我得到了同样的错误，这是由于我试图反序列化的类型没有默认的无参数构造函数。我添加了一个构造函数，它开始工作了。

XmlSerializer函数。FromTypes不会抛出异常，但它会泄漏内存。这就是为什么你需要为每个类型缓存这样的序列化器，以避免内存泄漏为每个创建的实例。

创建自己的XmlSerializer工厂并简单地使用它:

XmlSerializer serializer = XmlSerializerFactoryNoThrow.Create(typeof(MyType));

工厂是这样的:

public static class XmlSerializerFactoryNoThrow
{
    public static Dictionary<Type, XmlSerializer> _cache = new Dictionary<Type, XmlSerializer>();

    private static object SyncRootCache = new object();        

    /// <summary>
    /// //the constructor XmlSerializer.FromTypes does not throw exception, but it is said that it causes memory leaks
    /// http://stackoverflow.com/questions/1127431/xmlserializer-giving-filenotfoundexception-at-constructor
    /// That is why I use dictionary to cache the serializers my self.
    /// </summary>
    public static XmlSerializer Create(Type type)
    {
        XmlSerializer serializer;

        lock (SyncRootCache)
        {
            if (_cache.TryGetValue(type, out serializer))
                return serializer;
        }

        lock (type) //multiple variable of type of one type is same instance
        {
            //constructor XmlSerializer.FromTypes does not throw the first chance exception           
            serializer = XmlSerializer.FromTypes(new[] { type })[0];
            //serializer = XmlSerializerFactoryNoThrow.Create(type);
        }

        lock (SyncRootCache)
        {
            _cache[type] = serializer;
        }
        return serializer;
    }       
}

更复杂的版本，没有内存泄漏的可能性(请有人检查代码):

    public static XmlSerializer Create(Type type)
    {
        XmlSerializer serializer;

        lock (SyncRootCache)
        {
            if (_cache.TryGetValue(type, out serializer))
                return serializer;
        }

        lock (type) //multiple variable of type of one type is same instance
        {
            lock (SyncRootCache)
            {
                if (_cache.TryGetValue(type, out serializer))
                    return serializer;
            }
            serializer = XmlSerializer.FromTypes(new[] { type })[0];
            lock (SyncRootCache)
            {
                _cache[type] = serializer;
            }
        }          
        return serializer;
    }       
}

我也有同样的问题，直到我使用第三方工具从XSD生成类，它工作了!我发现这个工具在类的顶部添加了一些额外的代码。当我把同样的代码添加到我原来的类的顶部时，它起作用了。以下是我添加的内容……

#pragma warning disable
namespace MyNamespace
{
  using System;
  using System.Diagnostics;
  using System.Xml.Serialization;
  using System.Collections;
  using System.Xml.Schema;
  using System.ComponentModel;
  using System.Xml;
  using System.Collections.Generic;

  [System.CodeDom.Compiler.GeneratedCodeAttribute("System.Xml", "4.6.1064.2")]
  [System.SerializableAttribute()]
  [System.Diagnostics.DebuggerStepThroughAttribute()]
  [System.ComponentModel.DesignerCategoryAttribute("code")]
  [System.Xml.Serialization.XmlTypeAttribute(AnonymousType = true)]
  [System.Xml.Serialization.XmlRootAttribute(Namespace = "", IsNullable = false)]
  public partial class MyClassName
  {
  ...

您的类型可能会引用在GAC和本地bin文件夹中都找不到的其他程序集==>…

或其依赖项之一。该系统 无法找到指定的文件"

您能举例说明要序列化的类型吗?

注意:确保你的类型实现Serializable。