FWIW，多处理模块使用Pool类提供了一个很好的接口。如果您希望坚持使用线程而不是进程，可以直接使用multiprocessing.pool.ThreadPool类作为替代。

def foo(bar, baz):
  print 'hello {0}'.format(bar)
  return 'foo' + baz

from multiprocessing.pool import ThreadPool
pool = ThreadPool(processes=1)

async_result = pool.apply_async(foo, ('world', 'foo')) # tuple of args for foo

# do some other stuff in the main process

return_val = async_result.get()  # get the return value from your function.

考虑到@iman对@JakeBiesinger回答的评论，我重新组合了它，使其具有不同数量的线程:

from multiprocessing.pool import ThreadPool

def foo(bar, baz):
    print 'hello {0}'.format(bar)
    return 'foo' + baz

numOfThreads = 3 
results = []

pool = ThreadPool(numOfThreads)

for i in range(0, numOfThreads):
    results.append(pool.apply_async(foo, ('world', 'foo'))) # tuple of args for foo)

# do some other stuff in the main process
# ...
# ...

results = [r.get() for r in results]
print results

pool.close()
pool.join()

在Python 3.2+中，stdlib concurrent。futures模块为线程提供了一个更高级别的API，包括将返回值或异常从工作线程传递回主线程:

import concurrent.futures

def foo(bar):
    print('hello {}'.format(bar))
    return 'foo'

with concurrent.futures.ThreadPoolExecutor() as executor:
    future = executor.submit(foo, 'world!')
    return_value = future.result()
    print(return_value)

另一个不需要更改现有代码的解决方案:

import Queue             # Python 2.x
#from queue import Queue # Python 3.x

from threading import Thread

def foo(bar):
    print 'hello {0}'.format(bar)     # Python 2.x
    #print('hello {0}'.format(bar))   # Python 3.x
    return 'foo'

que = Queue.Queue()      # Python 2.x
#que = Queue()           # Python 3.x

t = Thread(target=lambda q, arg1: q.put(foo(arg1)), args=(que, 'world!'))
t.start()
t.join()
result = que.get()
print result             # Python 2.x
#print(result)           # Python 3.x

它也可以很容易地调整到多线程环境:

import Queue             # Python 2.x
#from queue import Queue # Python 3.x
from threading import Thread

def foo(bar):
    print 'hello {0}'.format(bar)     # Python 2.x
    #print('hello {0}'.format(bar))   # Python 3.x
    return 'foo'

que = Queue.Queue()      # Python 2.x
#que = Queue()           # Python 3.x

threads_list = list()

t = Thread(target=lambda q, arg1: q.put(foo(arg1)), args=(que, 'world!'))
t.start()
threads_list.append(t)

# Add more threads here
...
threads_list.append(t2)
...
threads_list.append(t3)
...

# Join all the threads
for t in threads_list:
    t.join()

# Check thread's return value
while not que.empty():
    result = que.get()
    print result         # Python 2.x
    #print(result)       # Python 3.x

这是我根据@Kindall的回答创建的版本。

这个版本使得您所要做的就是输入带有参数的命令来创建新线程。

这是用Python 3.8做的:

from threading import Thread
from typing import Any

def test(plug, plug2, plug3):
    print(f"hello {plug}")
    print(f'I am the second plug : {plug2}')
    print(plug3)
    return 'I am the return Value!'

def test2(msg):
    return f'I am from the second test: {msg}'

def test3():
    print('hello world')

def NewThread(com, Returning: bool, *arguments) -> Any:
    """
    Will create a new thread for a function/command.

    :param com: Command to be Executed
    :param arguments: Arguments to be sent to Command
    :param Returning: True/False Will this command need to return anything
    """
    class NewThreadWorker(Thread):
        def __init__(self, group = None, target = None, name = None, args = (), kwargs = None, *,
                     daemon = None):
            Thread.__init__(self, group, target, name, args, kwargs, daemon = daemon)
            
            self._return = None
        
        def run(self):
            if self._target is not None:
                self._return = self._target(*self._args, **self._kwargs)
        
        def join(self):
            Thread.join(self)
            return self._return
    
    ntw = NewThreadWorker(target = com, args = (*arguments,))
    ntw.start()
    if Returning:
        return ntw.join()

if __name__ == "__main__":
    print(NewThread(test, True, 'hi', 'test', test2('hi')))
    NewThread(test3, True)

GuySoft的想法很棒，但我认为对象不一定要从Thread继承，start()可以从接口中删除:

from threading import Thread
import queue
class ThreadWithReturnValue(object):
    def __init__(self, target=None, args=(), **kwargs):
        self._que = queue.Queue()
        self._t = Thread(target=lambda q,arg1,kwargs1: q.put(target(*arg1, **kwargs1)) ,
                args=(self._que, args, kwargs), )
        self._t.start()

    def join(self):
        self._t.join()
        return self._que.get()


def foo(bar):
    print('hello {0}'.format(bar))
    return "foo"

twrv = ThreadWithReturnValue(target=foo, args=('world!',))

print(twrv.join())   # prints foo