问题可能是线程从钩子调用你的代码还没有被运行时初始化，所以调用运行时方法不起作用。

也许您可以尝试执行Invoke将代码编组到UI线程，以调用将窗口带到前台的代码。

如果用户正在与另一个应用程序交互，则可能无法将您的应用程序放在前面。作为一般规则，只有当进程已经是前台进程时，该进程才能期望设置前台窗口。(微软在SetForegroundWindow() MSDN条目中记录了限制。)这是因为:

The user "owns" the foreground. For example, it would be extremely annoying if another program stole the foreground while the user is typing, at the very least interrupting her workflow, and possibly causing unintended consequences as her keystrokes meant for one application are misinterpreted by the offender until she notices the change. Imagine that each of two programs checks to see if its window is the foreground and attempts to set it to the foreground if it is not. As soon as the second program is running, the computer is rendered useless as the foreground bounces between the two at every task switch.

如果你试图隐藏窗口，例如你最小化窗口，我发现使用

    this.Hide();

将隐藏它正确，然后简单地使用

    this.Show();

然后将窗口再次显示为最上面的项目。

我知道这是一个很晚的答案，也许对研究人员有帮助

 if (!WindowName.IsVisible)
 {
     WindowName.Show();
     WindowName.Activate();
 }

这是上面几个简单有效的建议的结合。它只在那些事件触发时才出现在前面，因此事件之后弹出的任何窗口当然都会保持在顶部。

public partial class MainWindow : Window
{
    protected override void OnContentRendered(EventArgs e)
    {
        base.OnContentRendered(e);

        Topmost = true;
        Topmost = false;
    }
    protected override void OnInitialized(EventArgs e)
    {
        base.OnInitialized(e);

        Topmost = true;
        Topmost = false;
    }

    ....
}

只是想给这个问题加上一个解。这个实现适用于我的场景，其中CaliBurn负责显示主窗口。

protected override void OnStartup(object sender, StartupEventArgs e)
{
    DisplayRootViewFor<IMainWindowViewModel>();

    Application.MainWindow.Topmost = true;
    Application.MainWindow.Activate();
    Application.MainWindow.Activated += OnMainWindowActivated;
}

private static void OnMainWindowActivated(object sender, EventArgs e)
{
    var window = sender as Window;
    if (window != null)
    {
        window.Activated -= OnMainWindowActivated;
        window.Topmost = false;
        window.Focus();
    }
}