这里已经有了一些很好的答案。根据mdsharpe的建议，这里有一个扩展方法，当您想处理Uri实例时可以轻松使用：

using System;
using System.Linq;

public static class UriExtensions
{
    public static Uri Append(this Uri uri, params string[] paths)
    {
        return new Uri(paths.Aggregate(uri.AbsoluteUri, (current, path) => string.Format("{0}/{1}", current.TrimEnd('/'), path.TrimStart('/'))));
    }
}

使用示例：

var url = new Uri("http://example.com/subpath/").Append("/part1/", "part2").AbsoluteUri;

这将产生http://example.com/subpath/part1/part2

如果您希望使用字符串而不是Uris，那么以下操作也会产生相同的结果，只需根据您的需要进行调整即可：

public string JoinUriSegments(string uri, params string[] segments)
{
    if (string.IsNullOrWhiteSpace(uri))
        return null;

    if (segments == null || segments.Length == 0)
        return uri;

    return segments.Aggregate(uri, (current, segment) => $"{current.TrimEnd('/')}/{segment.TrimStart('/')}");
}

var uri = JoinUriSegements("http://example.com/subpath/", "/part1/", "part2");

这是Microsoft的（OfficeDev PnP）方法UrlUtility。组合：

    const char PATH_DELIMITER = '/';

    /// <summary>
    /// Combines a path and a relative path.
    /// </summary>
    /// <param name="path"></param>
    /// <param name="relative"></param>
    /// <returns></returns>
    public static string Combine(string path, string relative) 
    {
        if(relative == null)
            relative = String.Empty;

        if(path == null)
            path = String.Empty;

        if(relative.Length == 0 && path.Length == 0)
            return String.Empty;

        if(relative.Length == 0)
            return path;

        if(path.Length == 0)
            return relative;

        path = path.Replace('\\', PATH_DELIMITER);
        relative = relative.Replace('\\', PATH_DELIMITER);

        return path.TrimEnd(PATH_DELIMITER) + PATH_DELIMITER + relative.TrimStart(PATH_DELIMITER);
    }

来源：GitHub

如果您不想拥有像Flurl这样的依赖项，可以使用它的源代码：

    /// <summary>
    /// Basically a Path.Combine for URLs. Ensures exactly one '/' separates each segment,
    /// and exactly on '&amp;' separates each query parameter.
    /// URL-encodes illegal characters but not reserved characters.
    /// </summary>
    /// <param name="parts">URL parts to combine.</param>
    public static string Combine(params string[] parts) {
        if (parts == null)
            throw new ArgumentNullException(nameof(parts));

        string result = "";
        bool inQuery = false, inFragment = false;

        string CombineEnsureSingleSeparator(string a, string b, char separator) {
            if (string.IsNullOrEmpty(a)) return b;
            if (string.IsNullOrEmpty(b)) return a;
            return a.TrimEnd(separator) + separator + b.TrimStart(separator);
        }

        foreach (var part in parts) {
            if (string.IsNullOrEmpty(part))
                continue;

            if (result.EndsWith("?") || part.StartsWith("?"))
                result = CombineEnsureSingleSeparator(result, part, '?');
            else if (result.EndsWith("#") || part.StartsWith("#"))
                result = CombineEnsureSingleSeparator(result, part, '#');
            else if (inFragment)
                result += part;
            else if (inQuery)
                result = CombineEnsureSingleSeparator(result, part, '&');
            else
                result = CombineEnsureSingleSeparator(result, part, '/');

            if (part.Contains("#")) {
                inQuery = false;
                inFragment = true;
            }
            else if (!inFragment && part.Contains("?")) {
                inQuery = true;
            }
        }
        return EncodeIllegalCharacters(result);
    }

    /// <summary>
    /// URL-encodes characters in a string that are neither reserved nor unreserved. Avoids encoding reserved characters such as '/' and '?'. Avoids encoding '%' if it begins a %-hex-hex sequence (i.e. avoids double-encoding).
    /// </summary>
    /// <param name="s">The string to encode.</param>
    /// <param name="encodeSpaceAsPlus">If true, spaces will be encoded as + signs. Otherwise, they'll be encoded as %20.</param>
    /// <returns>The encoded URL.</returns>
    public static string EncodeIllegalCharacters(string s, bool encodeSpaceAsPlus = false) {
        if (string.IsNullOrEmpty(s))
            return s;

        if (encodeSpaceAsPlus)
            s = s.Replace(" ", "+");

        // Uri.EscapeUriString mostly does what we want - encodes illegal characters only - but it has a quirk
        // in that % isn't illegal if it's the start of a %-encoded sequence https://stackoverflow.com/a/47636037/62600

        // no % characters, so avoid the regex overhead
        if (!s.Contains("%"))
            return Uri.EscapeUriString(s);

        // pick out all %-hex-hex matches and avoid double-encoding 
        return Regex.Replace(s, "(.*?)((%[0-9A-Fa-f]{2})|$)", c => {
            var a = c.Groups[1].Value; // group 1 is a sequence with no %-encoding - encode illegal characters
            var b = c.Groups[2].Value; // group 2 is a valid 3-character %-encoded sequence - leave it alone!
            return Uri.EscapeUriString(a) + b;
        });
    }

值得一提的是，这里有几个扩展方法。第一个将合并路径，第二个将向URL添加参数。

    public static string CombineUrl(this string root, string path, params string[] paths)
    {
        if (string.IsNullOrWhiteSpace(path))
        {
            return root;
        }

        Uri baseUri = new Uri(root);
        Uri combinedPaths = new Uri(baseUri, path);

        foreach (string extendedPath in paths)
        {
           combinedPaths = new Uri(combinedPaths, extendedPath);
        }

        return combinedPaths.AbsoluteUri;
    }

    public static string AddUrlParams(this string url, Dictionary<string, string> parameters)
    {
        if (parameters == null || !parameters.Keys.Any())
        {
            return url;
        }

        var tempUrl = new StringBuilder($"{url}?");
        int count = 0;

        foreach (KeyValuePair<string, string> parameter in parameters)
        {
            if (count > 0)
            {
                tempUrl.Append("&");
            }

            tempUrl.Append($"{WebUtility.UrlEncode(parameter.Key)}={WebUtility.UrlEncode(parameter.Value)}");
            count++;
        }

        return tempUrl.ToString();
    }

这可能是一个合适的简单解决方案：

public static string Combine(string uri1, string uri2)
{
    uri1 = uri1.TrimEnd('/');
    uri2 = uri2.TrimStart('/');
    return string.Format("{0}/{1}", uri1, uri2);
}

将URL与URI组合时的规则

为了避免奇怪的行为，需要遵循一条规则：

路径（目录）必须以“/”结尾。如果路径结尾不带“/”，则最后一部分将被视为文件名，并且在尝试与下一个URL部分组合时将被连接。有一个例外：基本URL地址（没有目录信息）不需要以“/”结尾路径部分不能以“/”开头。如果它以“/”开头，则URL中的所有现有相关信息都将被删除。。。添加字符串。空的部分路径也会从URL中删除相对目录！

如果您遵循上面的规则，您可以将URL与下面的代码组合。根据您的情况，您可以向URL添加多个“目录”部分。。。

        var pathParts = new string[] { destinationBaseUrl, destinationFolderUrl, fileName };

        var destination = pathParts.Aggregate((left, right) =>
        {
            if (string.IsNullOrWhiteSpace(right))
                return left;

            return new Uri(new Uri(left), right).ToString();
        });