我认为这取决于你想做什么，你的问题没有详细说明。

对我来说，我想在一个已经多线程的进程中做一个昂贵的操作。所以我让leader流程检查时间，只有她做昂贵的操作(检查点深度学习模型)。为了做到这一点，我增加了计数器，以确保5秒、10秒、15秒过去，每5秒保存一次(或使用math.floor的模块化算术):

def print_every_5_seconds_have_passed_exit_eventually():
    """
    https://stackoverflow.com/questions/3393612/run-certain-code-every-n-seconds
    https://stackoverflow.com/questions/474528/what-is-the-best-way-to-repeatedly-execute-a-function-every-x-seconds
    :return:
    """
    opts = argparse.Namespace(start=time.time())
    next_time_to_print = 0
    while True:
        current_time_passed = time.time() - opts.start
        if current_time_passed >= next_time_to_print:
            next_time_to_print += 5
            print(f'worked and {current_time_passed=}')
            print(f'{current_time_passed % 5=}')
            print(f'{math.floor(current_time_passed % 5) == 0}')

starting __main__ at __init__
worked and current_time_passed=0.0001709461212158203
current_time_passed % 5=0.0001709461212158203
True
worked and current_time_passed=5.0
current_time_passed % 5=0.0
True
worked and current_time_passed=10.0
current_time_passed % 5=0.0
True
worked and current_time_passed=15.0
current_time_passed % 5=0.0
True

对我来说，检查if语句是我所需要的。在我已经复杂的多处理器多gpu代码中拥有线程，调度器并不是我想要添加的复杂性，如果我可以避免它，似乎我可以。检查worker id很容易确保只有一个进程在做这件事。

注意，我使用True print语句来确保模块化的算术技巧有效，因为检查确切的时间显然是行不通的!但令我惊喜的是，地板竟然起了作用。

它和cron之间的主要区别是异常会永久地杀死守护进程。您可能希望使用异常捕获器和记录器进行包装。

下面是MestreLion对代码的更新，它可以避免随着时间的推移而漂移。

这里的RepeatedTimer类按照OP的请求每隔“间隔”秒调用给定函数;调度并不取决于函数执行的时间。我喜欢这个解决方案，因为它没有外部库依赖关系;这是纯python。

import threading 
import time

class RepeatedTimer(object):
  def __init__(self, interval, function, *args, **kwargs):
    self._timer = None
    self.interval = interval
    self.function = function
    self.args = args
    self.kwargs = kwargs
    self.is_running = False
    self.next_call = time.time()
    self.start()

  def _run(self):
    self.is_running = False
    self.start()
    self.function(*self.args, **self.kwargs)

  def start(self):
    if not self.is_running:
      self.next_call += self.interval
      self._timer = threading.Timer(self.next_call - time.time(), self._run)
      self._timer.start()
      self.is_running = True

  def stop(self):
    self._timer.cancel()
    self.is_running = False

示例用法(摘自MestreLion的回答):

from time import sleep

def hello(name):
    print "Hello %s!" % name

print "starting..."
rt = RepeatedTimer(1, hello, "World") # it auto-starts, no need of rt.start()
try:
    sleep(5) # your long-running job goes here...
finally:
    rt.stop() # better in a try/finally block to make sure the program ends!

这里是另一个不使用任何额外库的解决方案。

def delay_until(condition_fn, interval_in_sec, timeout_in_sec):
    """Delay using a boolean callable function.

    `condition_fn` is invoked every `interval_in_sec` until `timeout_in_sec`.
    It can break early if condition is met.

    Args:
        condition_fn     - a callable boolean function
        interval_in_sec  - wait time between calling `condition_fn`
        timeout_in_sec   - maximum time to run

    Returns: None
    """
    start = last_call = time.time()
    while time.time() - start < timeout_in_sec:
        if (time.time() - last_call) > interval_in_sec:
            if condition_fn() is True:
                break
            last_call = time.time()

我用这个方法使每小时产生60个事件，其中大多数事件在整分钟后的相同秒数内发生:

import math
import time
import random

TICK = 60 # one minute tick size
TICK_TIMING = 59 # execute on 59th second of the tick
TICK_MINIMUM = 30 # minimum catch up tick size when lagging

def set_timing():

    now = time.time()
    elapsed = now - info['begin']
    minutes = math.floor(elapsed/TICK)
    tick_elapsed = now - info['completion_time']
    if (info['tick']+1) > minutes:
        wait = max(0,(TICK_TIMING-(time.time() % TICK)))
        print ('standard wait: %.2f' % wait)
        time.sleep(wait)
    elif tick_elapsed < TICK_MINIMUM:
        wait = TICK_MINIMUM-tick_elapsed
        print ('minimum wait: %.2f' % wait)
        time.sleep(wait)
    else:
        print ('skip set_timing(); no wait')
    drift = ((time.time() - info['begin']) - info['tick']*TICK -
        TICK_TIMING + info['begin']%TICK)
    print ('drift: %.6f' % drift)

info['tick'] = 0
info['begin'] = time.time()
info['completion_time'] = info['begin'] - TICK

while 1:

    set_timing()

    print('hello world')

    #random real world event
    time.sleep(random.random()*TICK_MINIMUM)

    info['tick'] += 1
    info['completion_time'] = time.time()

根据实际情况，你可能会得到长度的刻度:

60,60,62,58,60,60,120,30,30,60,60,60,60,60...etc.

但在60分钟结束时，你会有60个滴答;而且它们中的大多数都将出现在您喜欢的正确偏移时间。

在我的系统中，我得到了< 1/20秒的典型漂移，直到需要纠正。

该方法的优点是具有较好的时钟漂移分辨率;这可能会导致问题，如果你做的事情，比如每tick追加一个项目，你希望每小时追加60个项目。未能考虑漂移可能导致次要指标，如移动平均线，将数据考虑得过于深入过去，从而导致错误的输出。

像这样将你的时间循环锁定到系统时钟上:

import time
starttime = time.time()
while True:
    print("tick")
    time.sleep(60.0 - ((time.time() - starttime) % 60.0))