TLDR;不要使用synchronized修饰符或synchronized(this){…}表达式but synchronized(myLock){…其中myLock是一个持有私有对象的最终实例字段。

在方法声明中使用synchronized修饰符与在方法主体中使用synchronized(..){}表达式的区别如下:

The synchronized modifier specified on the method's signature is visible in the generated JavaDoc, is programmatically determinable via reflection when testing a method's modifier for Modifier.SYNCHRONIZED, requires less typing and indention compared to synchronized(this) { .... }, and (depending on your IDE) is visible in the class outline and code completion, uses the this object as lock when declared on non-static method or the enclosing class when declared on a static method. The synchronized(...){...} expression allows you to only synchronize the execution of parts of a method's body, to be used within a constructor or a (static) initialization block, to choose the lock object which controls the synchronized access.

然而，使用synchronized修饰符或synchronized(…){…}使用this作为锁对象(如synchronized(this){…})，也有同样的缺点。两者都使用它自己的实例作为锁对象进行同步。这是很危险的，因为不仅对象本身，而且任何其他持有该对象引用的外部对象/代码也可以将其用作同步锁，这可能会产生严重的副作用(性能下降和死锁)。

因此，最佳实践是既不使用synchronized修饰符，也不使用synchronized(…)表达式作为锁对象，而是使用该对象的私有锁对象。例如:

public class MyService {
    private final lock = new Object();

    public void doThis() {
       synchronized(lock) {
          // do code that requires synchronous execution
        }
    }

    public void doThat() {
       synchronized(lock) {
          // do code that requires synchronous execution
        }
    }
}

您也可以使用多个锁对象，但是需要特别注意，以确保在嵌套使用时不会导致死锁。

public class MyService {
    private final lock1 = new Object();
    private final lock2 = new Object();

    public void doThis() {
       synchronized(lock1) {
          synchronized(lock2) {
              // code here is guaranteed not to be executes at the same time
              // as the synchronized code in doThat() and doMore().
          }
    }

    public void doThat() {
       synchronized(lock1) {
              // code here is guaranteed not to be executes at the same time
              // as the synchronized code in doThis().
              // doMore() may execute concurrently
        }
    }

    public void doMore() {
       synchronized(lock2) {
              // code here is guaranteed not to be executes at the same time
              // as the synchronized code in doThis().
              // doThat() may execute concurrently
        }
    }
}

当java编译器将源代码转换为字节码时，它处理同步方法和同步块的方式非常不同。

当JVM执行一个同步方法时，执行线程识别出该方法的method_info结构体设置了ACC_SYNCHRONIZED标志，然后它自动获取对象的锁，调用该方法，并释放锁。如果发生异常，线程自动释放锁。

另一方面，同步方法块绕过了JVM对获取对象锁和异常处理的内置支持，并要求显式地用字节代码编写功能。如果读取带有同步块的方法的字节代码，您将看到十多个额外的操作来管理此功能。

这显示了生成同步方法和同步块的调用:

public class SynchronizationExample {
    private int i;

    public synchronized int synchronizedMethodGet() {
        return i;
    }

    public int synchronizedBlockGet() {
        synchronized( this ) {
            return i;
        }
    }
}

synchronizedMethodGet()方法生成以下字节代码:

0:  aload_0
1:  getfield
2:  nop
3:  iconst_m1
4:  ireturn

下面是synchronizedBlockGet()方法的字节代码:

0:  aload_0
1:  dup
2:  astore_1
3:  monitorenter
4:  aload_0
5:  getfield
6:  nop
7:  iconst_m1
8:  aload_1
9:  monitorexit
10: ireturn
11: astore_2
12: aload_1
13: monitorexit
14: aload_2
15: athrow

One significant difference between synchronized method and block is that, Synchronized block generally reduce scope of lock. As scope of lock is inversely proportional to performance, its always better to lock only critical section of code. One of the best example of using synchronized block is double checked locking in Singleton pattern where instead of locking whole getInstance() method we only lock critical section of code which is used to create Singleton instance. This improves performance drastically because locking is only required one or two times.

在使用同步方法时，如果混合使用静态同步方法和非静态同步方法，则需要格外小心。

使用同步块，您可以有多个同步器，因此多个同时但不冲突的事情可以同时进行。

来自Java规范摘要: http://www.cs.cornell.edu/andru/javaspec/17.doc.html

The synchronized statement (§14.17) computes a reference to an object; it then attempts to perform a lock action on that object and does not proceed further until the lock action has successfully completed. ... A synchronized method (§8.4.3.5) automatically performs a lock action when it is invoked; its body is not executed until the lock action has successfully completed. If the method is an instance method, it locks the lock associated with the instance for which it was invoked (that is, the object that will be known as this during execution of the body of the method). If the method is static, it locks the lock associated with the Class object that represents the class in which the method is defined. ...

基于这些描述，我想说以前的大多数答案都是正确的，同步方法可能对静态方法特别有用，否则您必须弄清楚如何获得“表示定义方法的类的Class对象”。

编辑:我原本以为这些是对实际Java规范的引用。澄清一下，本页只是对规范的总结/解释

主要的区别是，如果你使用同步块，你可以锁定一个对象，而不是这个，这允许更灵活。

假设您有一个消息队列和多个消息生产者和消费者。我们不希望生产者相互干扰，但是消费者应该能够检索消息，而不必等待生产者。 我们只需要创建一个对象

Object writeLock = new Object();

从现在开始，每当制作人想要添加一条新信息时，我们就会锁定它:

synchronized(writeLock){
  // do something
}

因此，消费者可能仍会阅读，而生产者将被锁定。

唯一真正的区别是同步块可以选择在哪个对象上同步。同步方法只能使用'this'(或同步类方法的相应Class实例)。例如，它们在语义上是等价的:

synchronized void foo() {
  ...
}

void foo() {
    synchronized (this) {
      ...
    }
}

后者更灵活，因为它可以竞争任何对象(通常是成员变量)的关联锁。它也更细粒度，因为您可以在块之前和块之后执行并发代码，但仍然在方法中。当然，您也可以通过将并发代码重构为单独的非同步方法来轻松地使用同步方法。使用任何使代码更容易理解的方法。