您可以使用OLEDB创建和操作Excel文件。选中此项：使用OLEDB读写Excel。

典型示例：

using (OleDbConnection conn = new OleDbConnection("Provider=Microsoft.Jet.OLEDB.4.0;Data Source=C:\\temp\\test.xls;Extended Properties='Excel 8.0;HDR=Yes'"))
{
  conn.Open();
  OleDbCommand cmd = new OleDbCommand("CREATE TABLE [Sheet1] ([Column1] string, [Column2] string)", conn);
  cmd.ExecuteNonQuery();
}

编辑-更多链接：

嘿，脚本人！如何在不使用Excel的情况下从Excel读取？如何使用ADO.NET在Visual Basic.NET中检索和修改Excel工作簿中的记录使用ADO.NET C#DbProviderFactory读写Excel电子表格

一个经常被忽略的简单选项是使用Microsoft Reporting创建.rdlc报告并将其导出为excel格式。您可以在visual studio中设计它，并使用以下方法生成文件：

localReport.Render("EXCELOPENXML", null, ((name, ext, encoding, mimeType, willSeek) => stream = new FileStream(name, FileMode.CreateNew)), out warnings);

您还可以分别使用“WORDOPENXML”和“pdf”将其导出为.doc或.pdf，并且它在许多不同的平台（如ASP.NET和SSRS）上都受支持。

在可视化设计器中进行更改要容易得多，在那里您可以看到结果，相信我，一旦开始分组数据、格式化组标题、添加新节，您就不想处理几十个XML节点。

您可以考虑使用XML Spreadsheet 2003格式创建文件。这是一种简单的XML格式，使用了一个文档化的模式。

我最近刚刚使用了FlexCel.NET，发现它是一个优秀的库！我对太多的软件产品不这么说。在这里进行整个销售宣传没有意义，你可以阅读他们网站上的所有功能。

这是一个商业产品，但如果你购买它，你会得到完整的源代码。所以我想，如果你真的想，你可以将它编译成你的程序集。否则，它只是一个额外的程序集来xcopy-没有配置或安装或类似的东西。

我认为，如果没有第三方库，您将找不到任何方法来做到这一点，因为.NET框架显然没有内置的支持，OLE自动化只是一个痛苦的世界。

您可以在Visual Studio上安装OpenXml nuget包。以下是将数据表导出到excel文件的代码：

Imports DocumentFormat.OpenXml
Imports DocumentFormat.OpenXml.Packaging
Imports DocumentFormat.OpenXml.Spreadsheet

Public Class ExportExcelClass
    Public Sub New()

    End Sub

    Public Sub ExportDataTable(ByVal table As DataTable, ByVal exportFile As String)
        ' Create a spreadsheet document by supplying the filepath.
        ' By default, AutoSave = true, Editable = true, and Type = xlsx.
        Dim spreadsheetDocument As SpreadsheetDocument = spreadsheetDocument.Create(exportFile, SpreadsheetDocumentType.Workbook)

        ' Add a WorkbookPart to the document.
        Dim workbook As WorkbookPart = spreadsheetDocument.AddWorkbookPart
        workbook.Workbook = New Workbook

        ' Add a WorksheetPart to the WorkbookPart.
        Dim Worksheet As WorksheetPart = workbook.AddNewPart(Of WorksheetPart)()
        Worksheet.Worksheet = New Worksheet(New SheetData())

        ' Add Sheets to the Workbook.
        Dim sheets As Sheets = spreadsheetDocument.WorkbookPart.Workbook.AppendChild(Of Sheets)(New Sheets())

        Dim data As SheetData = Worksheet.Worksheet.GetFirstChild(Of SheetData)()
        Dim Header As Row = New Row()
        Header.RowIndex = CType(1, UInt32)

        For Each column As DataColumn In table.Columns
            Dim headerCell As Cell = createTextCell(table.Columns.IndexOf(column) + 1, 1, column.ColumnName)
            Header.AppendChild(headerCell)
        Next

        data.AppendChild(Header)

        Dim contentRow As DataRow
        For i As Integer = 0 To table.Rows.Count - 1
            contentRow = table.Rows(i)
            data.AppendChild(createContentRow(contentRow, i + 2))
        Next

    End Sub

    Private Function createTextCell(ByVal columnIndex As Integer, ByVal rowIndex As Integer, ByVal cellValue As Object) As Cell
        Dim cell As Cell = New Cell()
        cell.DataType = CellValues.InlineString

        cell.CellReference = getColumnName(columnIndex) + rowIndex.ToString

        Dim inlineString As InlineString = New InlineString()
        Dim t As Text = New Text()
        t.Text = cellValue.ToString()
        inlineString.AppendChild(t)
        cell.AppendChild(inlineString)
        Return cell
    End Function

    Private Function createContentRow(ByVal dataRow As DataRow, ByVal rowIndex As Integer) As Row
        Dim row As Row = New Row With {
            .rowIndex = CType(rowIndex, UInt32)
        }

        For i As Integer = 0 To dataRow.Table.Columns.Count - 1
            Dim dataCell As Cell = createTextCell(i + 1, rowIndex, dataRow(i))
            row.AppendChild(dataCell)
        Next

        Return row
    End Function

    Private Function getColumnName(ByVal columnIndex As Integer) As String
        Dim dividend As Integer = columnIndex
        Dim columnName As String = String.Empty
        Dim modifier As Integer

        While dividend > 0
            modifier = (dividend - 1) Mod 26
            columnName = Convert.ToChar(65 + modifier).ToString() & columnName
            dividend = CInt(((dividend - modifier) / 26))
        End While

        Return columnName
    End Function
End Class

如果您从代码中创建数据表或数据网格视图，则可以使用此简单方法保存所有数据。不建议使用此方法，但它可以100%工作，即使您没有在计算机中安装MS Excel。

try
 {
  SaveFileDialog saveFileDialog1 = new SaveFileDialog();
  saveFileDialog1.Filter = "Excel Documents (*.xls)|*.xls";
  saveFileDialog1.FileName = "Employee Details.xls";
  if (saveFileDialog1.ShowDialog() == DialogResult.OK)
  {
  string fname = saveFileDialog1.FileName;
  StreamWriter wr = new StreamWriter(fname);
  for (int i = 0; i <DataTable.Columns.Count; i++)
  {
  wr.Write(DataTable.Columns[i].ToString().ToUpper() + "\t");
  }
  wr.WriteLine();

  //write rows to excel file
  for (int i = 0; i < (DataTable.Rows.Count); i++)
  {
  for (int j = 0; j < DataTable.Columns.Count; j++)
  {
  if (DataTable.Rows[i][j] != null)
  {
  wr.Write(Convert.ToString(getallData.Rows[i][j]) + "\t");
  }
   else
   {
   wr.Write("\t");
   }
   }
   //go to next line
   wr.WriteLine();
   }
   //close file
   wr.Close();
   }
   }
   catch (Exception)
   {
    MessageBox.Show("Error Create Excel Sheet!");
   }