这是我在swift中的解决方案。子类应该同时适用于attributedText和text属性以及characterSpacing + lineSpacing。如果设置了新字符串或attributedString，则保留空格。

open class UHBCustomLabel : UILabel {
    @IBInspectable open var characterSpacing:CGFloat = 1 {
        didSet {
            updateWithSpacing()
        }

    }
    @IBInspectable open var lines_spacing:CGFloat = -1 {
        didSet {
            updateWithSpacing()
        }

    }
    open override var text: String? {
        set {
            super.text = newValue
            updateWithSpacing()
        }
        get {
            return super.text
        }
    }
    open override var attributedText: NSAttributedString? {
        set {
            super.attributedText = newValue
            updateWithSpacing() 
        }
        get {
            return super.attributedText
        }
    }
    func updateWithSpacing() {
        let attributedString = self.attributedText == nil ? NSMutableAttributedString(string: self.text ?? "") : NSMutableAttributedString(attributedString: attributedText!)
        attributedString.addAttribute(NSKernAttributeName, value: self.characterSpacing, range: NSRange(location: 0, length: attributedString.length))
        if lines_spacing >= 0 {
            let paragraphStyle = NSMutableParagraphStyle()
            paragraphStyle.lineSpacing = lines_spacing
            paragraphStyle.alignment = textAlignment
            attributedString.addAttribute(NSParagraphStyleAttributeName, value:paragraphStyle, range:NSMakeRange(0, attributedString.length))
        }
        super.attributedText = attributedString
    }
}

在ios6中有另一个答案，那就是在标签上设置attributedText，使用NSAttributedString和适当的段落样式。关于NSAttributedString的行高，请参阅堆栈溢出答案:

NSAttributedString行高，对吗?

我想在这个答案中加入一些新的东西，这样我就不会感觉那么糟糕了……以下是斯威夫特的回答:

import Cocoa

let paragraphStyle = NSMutableParagraphStyle()
paragraphStyle.lineSpacing = 40

let attrString = NSMutableAttributedString(string: "Swift Answer")
attrString.addAttribute(.paragraphStyle, value:paragraphStyle, range:NSMakeRange(0, attrString.length))

var tableViewCell = NSTableCellView()
tableViewCell.textField.attributedStringValue = attrString

简单的回答是:你不能。要改变文本行间的间距，你必须继承UILabel并滚动自己的drawTextInRect，或者创建多个标签。”

参见:设置UILabel行间距

这是一个非常老的答案，其他人已经添加了新的更好的方法来处理这个问题。请参阅下面提供的最新答案。

另一个答案……如果你通过编程的方式传递字符串，你需要传递一个带属性的字符串，而不是一个普通的字符串，并改变它的风格。

NSMutableAttributedString * attrString = [[NSMutableAttributedString alloc] initWithString:@"Your \nregular \nstring"];
NSMutableParagraphStyle *style = [[NSMutableParagraphStyle alloc] init];
[style setLineSpacing:4];
[attrString addAttribute:NSParagraphStyleAttributeName
                   value:style
                   range:NSMakeRange(0, attrString.length)];
_label.attributedText = attrString;

根据@Mike的回答，减少lineHeightMultiple是关键点。下面的例子，它很适合我:

NSString* text = label.text;
CGFloat textWidth = [text sizeWithAttributes:@{NSFontAttributeName: label.font}].width;
if (textWidth > label.frame.size.width) {
  NSMutableParagraphStyle *paragraph = [[NSMutableParagraphStyle alloc] init];
  paragraph.alignment = NSTextAlignmentCenter;
  paragraph.lineSpacing = 1.0f;
  paragraph.lineHeightMultiple = 0.75;     // Reduce this value !!!
  NSMutableAttributedString* attrText = [[NSMutableAttributedString alloc] initWithString:text];
  [attrText addAttribute:NSParagraphStyleAttributeName value:paragraph range:NSMakeRange(0, text.length)];
  label.attributedText = attrText;
}

SWIFT 3有用的扩展设置行间的空间更容易:)

extension UILabel
{
    func setLineHeight(lineHeight: CGFloat)
    {
        let text = self.text
        if let text = text 
        {

            let attributeString = NSMutableAttributedString(string: text)
            let style = NSMutableParagraphStyle()

           style.lineSpacing = lineHeight
           attributeString.addAttribute(NSParagraphStyleAttributeName,
                                        value: style,
                                        range: NSMakeRange(0, text.characters.count))

           self.attributedText = attributeString
        }
    }
}