根据@Mike的回答，减少lineHeightMultiple是关键点。下面的例子，它很适合我:

NSString* text = label.text;
CGFloat textWidth = [text sizeWithAttributes:@{NSFontAttributeName: label.font}].width;
if (textWidth > label.frame.size.width) {
  NSMutableParagraphStyle *paragraph = [[NSMutableParagraphStyle alloc] init];
  paragraph.alignment = NSTextAlignmentCenter;
  paragraph.lineSpacing = 1.0f;
  paragraph.lineHeightMultiple = 0.75;     // Reduce this value !!!
  NSMutableAttributedString* attrText = [[NSMutableAttributedString alloc] initWithString:text];
  [attrText addAttribute:NSParagraphStyleAttributeName value:paragraph range:NSMakeRange(0, text.length)];
  label.attributedText = attrText;
}

这应该会有帮助。然后你可以将你的标签分配给故事板中的这个自定义类，并直接在属性中使用它的参数:

open class SpacingLabel : UILabel {

    @IBInspectable open var lineHeight:CGFloat = 1 {
        didSet {
            let paragraphStyle = NSMutableParagraphStyle()
            paragraphStyle.lineSpacing = 1.0
            paragraphStyle.lineHeightMultiple = self.lineHeight
            paragraphStyle.alignment = self.textAlignment

            let attrString = NSMutableAttributedString(string: self.text!)
            attrString.addAttribute(NSAttributedStringKey.font, value: self.font, range: NSMakeRange(0, attrString.length))
            attrString.addAttribute(NSAttributedStringKey.paragraphStyle, value:paragraphStyle, range:NSMakeRange(0, attrString.length))
            self.attributedText = attrString
        }
    } 
}

另一个答案……如果你通过编程的方式传递字符串，你需要传递一个带属性的字符串，而不是一个普通的字符串，并改变它的风格。

NSMutableAttributedString * attrString = [[NSMutableAttributedString alloc] initWithString:@"Your \nregular \nstring"];
NSMutableParagraphStyle *style = [[NSMutableParagraphStyle alloc] init];
[style setLineSpacing:4];
[attrString addAttribute:NSParagraphStyleAttributeName
                   value:style
                   range:NSMakeRange(0, attrString.length)];
_label.attributedText = attrString;

下面是一个子类UILabel具有行高属性的类:https://github.com/LemonCake/MSLabel

我想在这个答案中加入一些新的东西，这样我就不会感觉那么糟糕了……以下是斯威夫特的回答:

import Cocoa

let paragraphStyle = NSMutableParagraphStyle()
paragraphStyle.lineSpacing = 40

let attrString = NSMutableAttributedString(string: "Swift Answer")
attrString.addAttribute(.paragraphStyle, value:paragraphStyle, range:NSMakeRange(0, attrString.length))

var tableViewCell = NSTableCellView()
tableViewCell.textField.attributedStringValue = attrString

简单的回答是:你不能。要改变文本行间的间距，你必须继承UILabel并滚动自己的drawTextInRect，或者创建多个标签。”

参见:设置UILabel行间距

这是一个非常老的答案，其他人已经添加了新的更好的方法来处理这个问题。请参阅下面提供的最新答案。

下面是UILabel的一个子类，它设置lineHeightMultiple并确保内在高度足够大，不会截断文本。

@IBDesignable
class Label: UILabel {
    override var intrinsicContentSize: CGSize {
        var size = super.intrinsicContentSize
        let padding = (1.0 - lineHeightMultiple) * font.pointSize
        size.height += padding
        return size
    }

    override var text: String? {
        didSet {
            updateAttributedText()
        }
    }

    @IBInspectable var lineHeightMultiple: CGFloat = 1.0 {
        didSet {
            updateAttributedText()
        }
    }

    private func updateAttributedText() {
        let paragraphStyle = NSMutableParagraphStyle()
        paragraphStyle.lineHeightMultiple = lineHeightMultiple
        attributedText = NSAttributedString(string: text ?? "", attributes: [
            .font: font,
            .paragraphStyle: paragraphStyle,
            .foregroundColor: textColor
        ])
        invalidateIntrinsicContentSize()
    }
}