根据@Mike的回答，减少lineHeightMultiple是关键点。下面的例子，它很适合我:

NSString* text = label.text;
CGFloat textWidth = [text sizeWithAttributes:@{NSFontAttributeName: label.font}].width;
if (textWidth > label.frame.size.width) {
  NSMutableParagraphStyle *paragraph = [[NSMutableParagraphStyle alloc] init];
  paragraph.alignment = NSTextAlignmentCenter;
  paragraph.lineSpacing = 1.0f;
  paragraph.lineHeightMultiple = 0.75;     // Reduce this value !!!
  NSMutableAttributedString* attrText = [[NSMutableAttributedString alloc] initWithString:text];
  [attrText addAttribute:NSParagraphStyleAttributeName value:paragraph range:NSMakeRange(0, text.length)];
  label.attributedText = attrText;
}

在ios6中有另一个答案，那就是在标签上设置attributedText，使用NSAttributedString和适当的段落样式。关于NSAttributedString的行高，请参阅堆栈溢出答案:

NSAttributedString行高，对吗?

在Swift中，作为一个函数，灵感来自DarkDust

// Usage: setTextWithLineSpacing(myEpicUILabel,text:"Hello",lineSpacing:20)
func setTextWithLineSpacing(label:UILabel,text:String,lineSpacing:CGFloat)
{
    let paragraphStyle = NSMutableParagraphStyle()
    paragraphStyle.lineSpacing = lineSpacing

    let attrString = NSMutableAttributedString(string: text)
    attrString.addAttribute(NSAttributedString.Key.paragraphStyle, value:paragraphStyle, range:NSMakeRange(0, attrString.length))

    label.attributedText = attrString
}

从接口生成器(Storyboard/XIB):

编程:

斯威夫特4

使用标签扩展

extension UILabel {

    // Pass value for any one of both parameters and see result
    func setLineSpacing(lineSpacing: CGFloat = 0.0, lineHeightMultiple: CGFloat = 0.0) {

        guard let labelText = self.text else { return }

        let paragraphStyle = NSMutableParagraphStyle()
        paragraphStyle.lineSpacing = lineSpacing
        paragraphStyle.lineHeightMultiple = lineHeightMultiple

        let attributedString:NSMutableAttributedString
        if let labelattributedText = self.attributedText {
            attributedString = NSMutableAttributedString(attributedString: labelattributedText)
        } else {
            attributedString = NSMutableAttributedString(string: labelText)
        }

        // Line spacing attribute
        attributedString.addAttribute(NSAttributedStringKey.paragraphStyle, value:paragraphStyle, range:NSMakeRange(0, attributedString.length))

        self.attributedText = attributedString
    }
}

现在调用扩展函数

let label = UILabel()
let stringValue = "How to\ncontrol\nthe\nline spacing\nin UILabel"

// Pass value for any one argument - lineSpacing or lineHeightMultiple
label.setLineSpacing(lineSpacing: 2.0) .  // try values 1.0 to 5.0

// or try lineHeightMultiple
//label.setLineSpacing(lineHeightMultiple = 2.0) // try values 0.5 to 2.0

或者使用标签实例(只要复制并执行这段代码就可以看到结果)

let label = UILabel()
let stringValue = "How to\ncontrol\nthe\nline spacing\nin UILabel"
let attrString = NSMutableAttributedString(string: stringValue)
var style = NSMutableParagraphStyle()
style.lineSpacing = 24 // change line spacing between paragraph like 36 or 48
style.minimumLineHeight = 20 // change line spacing between each line like 30 or 40

// Line spacing attribute
attrString.addAttribute(NSAttributedStringKey.paragraphStyle, value: style, range: NSRange(location: 0, length: stringValue.characters.count))

// Character spacing attribute
attrString.addAttribute(NSAttributedStringKey.kern, value: 2, range: NSMakeRange(0, attrString.length))

label.attributedText = attrString

斯威夫特3

let label = UILabel()
let stringValue = "How to\ncontrol\nthe\nline spacing\nin UILabel"
let attrString = NSMutableAttributedString(string: stringValue)
var style = NSMutableParagraphStyle()
style.lineSpacing = 24 // change line spacing between paragraph like 36 or 48
style.minimumLineHeight = 20 // change line spacing between each line like 30 or 40
attrString.addAttribute(NSParagraphStyleAttributeName, value: style, range: NSRange(location: 0, length: stringValue.characters.count))
label.attributedText = attrString

SWIFT 3有用的扩展设置行间的空间更容易:)

extension UILabel
{
    func setLineHeight(lineHeight: CGFloat)
    {
        let text = self.text
        if let text = text 
        {

            let attributeString = NSMutableAttributedString(string: text)
            let style = NSMutableParagraphStyle()

           style.lineSpacing = lineHeight
           attributeString.addAttribute(NSParagraphStyleAttributeName,
                                        value: style,
                                        range: NSMakeRange(0, text.characters.count))

           self.attributedText = attributeString
        }
    }
}

从ios6开始，你可以为UILabel设置带属性字符串。检查以下内容:

NSMutableAttributedString *attributedString = [[NSMutableAttributedString alloc] initWithString:label.text];
NSMutableParagraphStyle *paragraphStyle = [[NSMutableParagraphStyle alloc] init];
paragraphStyle.lineSpacing = spacing;
[attributedString addAttribute:NSParagraphStyleAttributeName value:paragraphStyle range:NSMakeRange(0, label.text.length)];

label.attributedText = attributedString;