根据@Mike的回答，减少lineHeightMultiple是关键点。下面的例子，它很适合我:

NSString* text = label.text;
CGFloat textWidth = [text sizeWithAttributes:@{NSFontAttributeName: label.font}].width;
if (textWidth > label.frame.size.width) {
  NSMutableParagraphStyle *paragraph = [[NSMutableParagraphStyle alloc] init];
  paragraph.alignment = NSTextAlignmentCenter;
  paragraph.lineSpacing = 1.0f;
  paragraph.lineHeightMultiple = 0.75;     // Reduce this value !!!
  NSMutableAttributedString* attrText = [[NSMutableAttributedString alloc] initWithString:text];
  [attrText addAttribute:NSParagraphStyleAttributeName value:paragraph range:NSMakeRange(0, text.length)];
  label.attributedText = attrText;
}

我想在这个答案中加入一些新的东西，这样我就不会感觉那么糟糕了……以下是斯威夫特的回答:

import Cocoa

let paragraphStyle = NSMutableParagraphStyle()
paragraphStyle.lineSpacing = 40

let attrString = NSMutableAttributedString(string: "Swift Answer")
attrString.addAttribute(.paragraphStyle, value:paragraphStyle, range:NSMakeRange(0, attrString.length))

var tableViewCell = NSTableCellView()
tableViewCell.textField.attributedStringValue = attrString

简单的回答是:你不能。要改变文本行间的间距，你必须继承UILabel并滚动自己的drawTextInRect，或者创建多个标签。”

参见:设置UILabel行间距

这是一个非常老的答案，其他人已经添加了新的更好的方法来处理这个问题。请参阅下面提供的最新答案。

下面是一个子类UILabel具有行高属性的类:https://github.com/LemonCake/MSLabel

Swift 3扩展:

import UIKit
    
extension UILabel {
  func setTextWithLineSpacing(text: String, lineHeightMultiply: CGFloat = 1.3) {
    let paragraphStyle = NSMutableParagraphStyle()
    paragraphStyle.lineHeightMultiple = lineHeightMultiply
    paragraphStyle.alignment = .center
    let attributedString = NSMutableAttributedString(string: text)
    attributedString.addAttribute(NSParagraphStyleAttributeName, value: paragraphStyle, range: NSRange(location: 0, length: attributedString.length))
    self.attributedText = attributedString
  }
}

在UITextView或UILabel扩展中，添加这个函数:

我添加了一些代码来保持当前的带属性文本，如果您已经在视图中使用带属性字符串(而不是覆盖它们)。

func setLineHeight(_ lineHeight: CGFloat) {
    guard let text = self.text, let font = self.font else { return }

    let paragraphStyle = NSMutableParagraphStyle()
    paragraphStyle.lineSpacing = 1.0
    paragraphStyle.lineHeightMultiple = lineHeight
    paragraphStyle.alignment = self.textAlignment

    var attrString:NSMutableAttributedString
    if let attributed = self.attributedText {
        attrString = NSMutableAttributedString(attributedString: attributed)
    } else {
        attrString = NSMutableAttributedString(string: text)
        attrString.addAttribute(NSFontAttributeName, value: font, range: NSMakeRange(0, attrString.length))
    }
    attrString.addAttribute(NSParagraphStyleAttributeName, value:paragraphStyle, range:NSMakeRange(0, attrString.length))
    self.attributedText = attrString
}

在Xcode 6中，你可以在storyboard中这样做: