从ios6开始，你可以为UILabel设置带属性字符串。检查以下内容:

NSMutableAttributedString *attributedString = [[NSMutableAttributedString alloc] initWithString:label.text];
NSMutableParagraphStyle *paragraphStyle = [[NSMutableParagraphStyle alloc] init];
paragraphStyle.lineSpacing = spacing;
[attributedString addAttribute:NSParagraphStyleAttributeName value:paragraphStyle range:NSMakeRange(0, label.text.length)];

label.attributedText = attributedString;

SWIFT 3有用的扩展设置行间的空间更容易:)

extension UILabel
{
    func setLineHeight(lineHeight: CGFloat)
    {
        let text = self.text
        if let text = text 
        {

            let attributeString = NSMutableAttributedString(string: text)
            let style = NSMutableParagraphStyle()

           style.lineSpacing = lineHeight
           attributeString.addAttribute(NSParagraphStyleAttributeName,
                                        value: style,
                                        range: NSMakeRange(0, text.characters.count))

           self.attributedText = attributeString
        }
    }
}

我想在这个答案中加入一些新的东西，这样我就不会感觉那么糟糕了……以下是斯威夫特的回答:

import Cocoa

let paragraphStyle = NSMutableParagraphStyle()
paragraphStyle.lineSpacing = 40

let attrString = NSMutableAttributedString(string: "Swift Answer")
attrString.addAttribute(.paragraphStyle, value:paragraphStyle, range:NSMakeRange(0, attrString.length))

var tableViewCell = NSTableCellView()
tableViewCell.textField.attributedStringValue = attrString

简单的回答是:你不能。要改变文本行间的间距，你必须继承UILabel并滚动自己的drawTextInRect，或者创建多个标签。”

参见:设置UILabel行间距

这是一个非常老的答案，其他人已经添加了新的更好的方法来处理这个问题。请参阅下面提供的最新答案。

下面是一个子类UILabel具有行高属性的类:https://github.com/LemonCake/MSLabel

在Swift中，作为一个函数，灵感来自DarkDust

// Usage: setTextWithLineSpacing(myEpicUILabel,text:"Hello",lineSpacing:20)
func setTextWithLineSpacing(label:UILabel,text:String,lineSpacing:CGFloat)
{
    let paragraphStyle = NSMutableParagraphStyle()
    paragraphStyle.lineSpacing = lineSpacing

    let attrString = NSMutableAttributedString(string: text)
    attrString.addAttribute(NSAttributedString.Key.paragraphStyle, value:paragraphStyle, range:NSMakeRange(0, attrString.length))

    label.attributedText = attrString
}

根据@Mike的回答，减少lineHeightMultiple是关键点。下面的例子，它很适合我:

NSString* text = label.text;
CGFloat textWidth = [text sizeWithAttributes:@{NSFontAttributeName: label.font}].width;
if (textWidth > label.frame.size.width) {
  NSMutableParagraphStyle *paragraph = [[NSMutableParagraphStyle alloc] init];
  paragraph.alignment = NSTextAlignmentCenter;
  paragraph.lineSpacing = 1.0f;
  paragraph.lineHeightMultiple = 0.75;     // Reduce this value !!!
  NSMutableAttributedString* attrText = [[NSMutableAttributedString alloc] initWithString:text];
  [attrText addAttribute:NSParagraphStyleAttributeName value:paragraph range:NSMakeRange(0, text.length)];
  label.attributedText = attrText;
}