如果我是你，我会这样做:

Debug.Assert(val != null);
if ( val == null )
    throw new exception();

或者避免重复条件检查

if ( val == null )
{
    Debug.Assert(false,"breakpoint if val== null");
    throw new exception();
}

我不会在产品代码中使用它们。抛出异常，捕获和记录。

在asp.net中也需要小心，因为断言可以显示在控制台上并冻结请求。

摘自Code Complete (Wikipedia):

8 Defensive Programming 8.2 Assertions An assertion is code that’s used during development—usually a routine or macro—that allows a program to check itself as it runs. When an assertion is true, that means everything is operating as expected. When it’s false, that means it has detected an unexpected error in the code. For example, if the system assumes that a customer-information file will never have more than 50,000 records, the program might contain an assertion that the number of records is lessthan or equal to 50,000. As long as the number of records is less than or equal to 50,000, the assertion will be silent. If it encounters more than 50,000 records, however, it will loudly “assert” that there is an error in the program. Assertions are especially useful in large, complicated programs and in high reliability programs. They enable programmers to more quickly flush out mismatched interface assumptions, errors that creep in when code is modified, and so on. An assertion usually takes two arguments: a boolean expression that describes the assumption that’s supposed to be true and a message to display if it isn’t. (…) Normally, you don’t want users to see assertion messages in production code; assertions are primarily for use during development and maintenance. Assertions are normally compiled into the code at development time and compiled out of the code for production. During development, assertions flush out contradictory assumptions, unexpected conditions, bad values passed to routines, and so on. During production, they are compiled out of the code so that the assertions don’t degrade system performance.

使用断言检查开发人员的假设，使用异常检查环境的假设。

我已经在这里阅读了答案，我认为我应该添加一个重要的区别。使用断言有两种非常不同的方式。一种是作为临时的开发人员快捷方式，表示“这不应该真的发生，所以如果它发生了，就告诉我，这样我就可以决定怎么做”，有点像一个条件断点，用于你的程序能够继续的情况。另一种方法是在代码中假设有效的程序状态。

在第一种情况下，断言甚至不需要出现在最终代码中。您应该使用Debug。在开发期间断言，如果/当不再需要时，您可以删除它们。如果你想要保留它们或者忘记删除它们，没有问题，因为它们在发布汇编中不会有任何后果。

But in the second case, the assertions are part of the code. They, well, assert, that your assumptions are true, and also document them. In that case, you really want to leave them in the code. If the program is in an invalid state it should not be allowed to continue. If you couldn't afford the performance hit you wouldn't be using C#. On one hand it might be useful to be able to attach a debugger if it happens. On the other, you don't want the stack trace popping up on your users and perhaps more important you don't want them to be able to ignore it. Besides, if it's in a service it will always be ignored. Therefore in production the correct behavior would be to throw an Exception, and use the normal exception handling of your program, which might show the user a nice message and log the details.

跟踪。Assert有实现这一点的完美方法。它不会在生产环境中被删除，并且可以使用app.config配置不同的侦听器。 因此，对于开发来说，默认的处理程序就可以了，对于生产来说，您可以创建一个简单的TraceListener(如下所示)，它会抛出一个异常并在生产配置文件中激活它。

using System.Diagnostics;

public class ExceptionTraceListener : DefaultTraceListener
{
    [DebuggerStepThrough]
    public override void Fail(string message, string detailMessage)
    {
        throw new AssertException(message);
    }
}

public class AssertException : Exception
{
    public AssertException(string message) : base(message) { }
}

在产品配置文件中:

<system.diagnostics>
  <trace>
    <listeners>
      <remove name="Default"/>
      <add name="ExceptionListener" type="Namespace.ExceptionTraceListener,AssemblyName"/>
    </listeners>
  </trace>
 </system.diagnostics>

摘自《实用程序员:从熟练工到高手》

Leave Assertions Turned On There is a common misunderstanding about assertions, promulgated by the people who write compilers and language environments. It goes something like this: Assertions add some overhead to code. Because they check for things that should never happen, they'll get triggered only by a bug in the code. Once the code has been tested and shipped, they are no longer needed, and should be turned off to make the code run faster. Assertions are a debugging facility. There are two patently wrong assumptions here. First, they assume that testing finds all the bugs. In reality, for any complex program you are unlikely to test even a miniscule percentage of the permutations your code will be put through (see Ruthless Testing). Second, the optimists are forgetting that your program runs in a dangerous world. During testing, rats probably won't gnaw through a communications cable, someone playing a game won't exhaust memory, and log files won't fill the hard drive. These things might happen when your program runs in a production environment. Your first line of defense is checking for any possible error, and your second is using assertions to try to detect those you've missed. Turning off assertions when you deliver a program to production is like crossing a high wire without a net because you once made it across in practice. There's dramatic value, but it's hard to get life insurance. Even if you do have performance issues, turn off only those assertions that really hit you.