如果你可以不使用文本包装，我认为用标签替换TextBlock是最简洁的方法。否则，从其他有效答案中选择一个。

<Label Content="Some Text" VerticalAlignment="Center"/>

只是为了好玩，试试这个XAML吧。它不是完美的，因为它不是一个“对齐”，但它允许你调整一个段落中的文本对齐。

<TextBlock>
    <TextBlock BaselineOffset="30">One</TextBlock>
    <TextBlock BaselineOffset="20">Two</TextBlock>  
    <Run>Three</Run>            
    <Run BaselineAlignment="Subscript">Four</Run>   
</TextBlock>

对我来说，VerticalAlignment=“中心”修复了这个问题。 这可能是因为textblock被包装在一个网格中，但实际上是wpf中的一切。

  <TextBox AcceptsReturn="True" 
           TextWrapping="Wrap"  
           VerticalContentAlignment="Top" >
  </TextBox>

To expand on the answer provided by @Orion Edwards, this is how you would do fully from code-behind (no styles set). Basically create a custom class that inherits from Border which has its Child set to a TextBox. The example below assumes that you only want a single line and that the border is a child of a Canvas. Also assumes you would need to adjust the MaxLength property of the TextBox based on the width of the Border. The example below also sets the cursor of the Border to mimic a Textbox by setting it to the type 'IBeam'. A margin of '3' is set so that the TextBox isn't absolutely aligned to the left of the border.

double __dX = 20;
double __dY = 180;
double __dW = 500;
double __dH = 40;
int __iMaxLen = 100;

this.m_Z3r0_TextBox_Description = new CZ3r0_TextBox(__dX, __dY, __dW, __dH, __iMaxLen, TextAlignment.Left);
this.Children.Add(this.m_Z3r0_TextBox_Description);

类:

using System;
using System.Collections.Generic;
using System.Text;
using System.Windows;
using System.Windows.Controls;
using System.Windows.Input;
using System.Windows.Media;
using System.Windows.Shapes;
using System.Windows.Controls.Primitives;


namespace ifn0tz3r0Exp
{
    class CZ3r0_TextBox : Border
    {
        private TextBox m_TextBox;

        private SolidColorBrush m_Brush_Green = new SolidColorBrush(Colors.MediumSpringGreen);
        private SolidColorBrush m_Brush_Black = new SolidColorBrush(Colors.Black);
        private SolidColorBrush m_Brush_Transparent = new SolidColorBrush(Colors.Transparent);

        public CZ3r0_TextBox(double _dX, double _dY, double _dW, double _dH, int _iMaxLen, TextAlignment _Align)
        {

            /////////////////////////////////////////////////////////////
            //TEXTBOX
            this.m_TextBox = new TextBox();
            this.m_TextBox.Text = "This is a vertically centered one-line textbox embedded in a border...";
            Canvas.SetLeft(this, _dX);
            Canvas.SetTop(this, _dY);
            this.m_TextBox.FontFamily = new FontFamily("Consolas");
            this.m_TextBox.FontSize = 11;
            this.m_TextBox.Background = this.m_Brush_Black;
            this.m_TextBox.Foreground = this.m_Brush_Green;
            this.m_TextBox.BorderBrush = this.m_Brush_Transparent;
            this.m_TextBox.BorderThickness = new Thickness(0.0);
            this.m_TextBox.Width = _dW;
            this.m_TextBox.MaxLength = _iMaxLen;
            this.m_TextBox.TextAlignment = _Align;
            this.m_TextBox.VerticalAlignment = System.Windows.VerticalAlignment.Center;
            this.m_TextBox.FocusVisualStyle = null;
            this.m_TextBox.Margin = new Thickness(3.0);
            this.m_TextBox.CaretBrush = this.m_Brush_Green;
            this.m_TextBox.SelectionBrush = this.m_Brush_Green;
            this.m_TextBox.SelectionOpacity = 0.3;

            this.m_TextBox.GotFocus += this.CZ3r0_TextBox_GotFocus;
            this.m_TextBox.LostFocus += this.CZ3r0_TextBox_LostFocus;
            /////////////////////////////////////////////////////////////
            //BORDER

            this.BorderBrush = this.m_Brush_Transparent;
            this.BorderThickness = new Thickness(1.0);
            this.Background = this.m_Brush_Black;            
            this.Height = _dH;
            this.Child = this.m_TextBox;
            this.FocusVisualStyle = null;
            this.MouseDown += this.CZ3r0_TextBox_MouseDown;
            this.Cursor = Cursors.IBeam;
            /////////////////////////////////////////////////////////////
        }
        private void CZ3r0_TextBox_MouseDown(object _Sender, MouseEventArgs e)
        {
            this.m_TextBox.Focus();
        }
        private void CZ3r0_TextBox_GotFocus(object _Sender, RoutedEventArgs e)
        {
            this.BorderBrush = this.m_Brush_Green;
        }
        private void CZ3r0_TextBox_LostFocus(object _Sender, RoutedEventArgs e)
        {
            this.BorderBrush = this.m_Brush_Transparent;
        }
    }
}

一个文本块本身不能做垂直对齐

最好的方法，这样做，我发现是把文本块内的边界，所以边界为您对齐。

<Border BorderBrush="{x:Null}" Height="50">
    <TextBlock TextWrapping="Wrap" Text="Some Text" VerticalAlignment="Center"/>
</Border>

注意:这在功能上等同于使用网格，它只是取决于你想让控件如何与你的布局的其余部分相适应，以确定哪个更适合