如果你可以不使用文本包装，我认为用标签替换TextBlock是最简洁的方法。否则，从其他有效答案中选择一个。

<Label Content="Some Text" VerticalAlignment="Center"/>

虽然Orion Edwards Answer适用于任何情况，但每次想要这样做时，添加边界和设置边界的属性可能是一件痛苦的事情。另一个快速的方法是设置文本块的填充:

<TextBlock Height="22" Padding="3" />

TextBlock不支持其内容的垂直对齐。如果你必须使用TextBlock，那么你必须对齐它与它的父。

然而，如果你可以使用标签代替(他们确实有非常相似的功能)，那么你可以定位文本内容:

<Label VerticalContentAlignment="Center" HorizontalContentAlignment="Center">
   I am centred text!
</Label>

默认情况下，标签将拉伸以填充其边界，这意味着标签的文本将居中。

在我的情况下，我这样做是为了使TextBlock显示更好。

<Border BorderThickness="3" BorderBrush="Yellow" CornerRadius="10" Padding="2"
    HorizontalAlignment="Center" VerticalAlignment="Center" Height="30" Width="150">
        <TextBlock FontSize="20" Height="23" HorizontalAlignment="Left" Margin="0,0,0,-5" Text="" VerticalAlignment="Top" Width="141" Background="White" />
</Border>

使文本离底部更远的技巧是设置

Margin="0,0,0,-5"

我认为最好是使用一个标签(或TextBlock)变成一个标签，你不能直接在边界控件中附加鼠标事件，最后它附加在TextBlock中，这是我的建议:

<Label 
    Height="32"
    VerticalContentAlignment="Center"
    HorizontalContentAlignment="Stretch"
    MouseLeftButtonUp="MenuItem_MouseLeftButtonUp">
    <TextBlock Padding="32 0 10 0">
        Label with click event
    </TextBlock>
</Label>

To expand on the answer provided by @Orion Edwards, this is how you would do fully from code-behind (no styles set). Basically create a custom class that inherits from Border which has its Child set to a TextBox. The example below assumes that you only want a single line and that the border is a child of a Canvas. Also assumes you would need to adjust the MaxLength property of the TextBox based on the width of the Border. The example below also sets the cursor of the Border to mimic a Textbox by setting it to the type 'IBeam'. A margin of '3' is set so that the TextBox isn't absolutely aligned to the left of the border.

double __dX = 20;
double __dY = 180;
double __dW = 500;
double __dH = 40;
int __iMaxLen = 100;

this.m_Z3r0_TextBox_Description = new CZ3r0_TextBox(__dX, __dY, __dW, __dH, __iMaxLen, TextAlignment.Left);
this.Children.Add(this.m_Z3r0_TextBox_Description);

类:

using System;
using System.Collections.Generic;
using System.Text;
using System.Windows;
using System.Windows.Controls;
using System.Windows.Input;
using System.Windows.Media;
using System.Windows.Shapes;
using System.Windows.Controls.Primitives;


namespace ifn0tz3r0Exp
{
    class CZ3r0_TextBox : Border
    {
        private TextBox m_TextBox;

        private SolidColorBrush m_Brush_Green = new SolidColorBrush(Colors.MediumSpringGreen);
        private SolidColorBrush m_Brush_Black = new SolidColorBrush(Colors.Black);
        private SolidColorBrush m_Brush_Transparent = new SolidColorBrush(Colors.Transparent);

        public CZ3r0_TextBox(double _dX, double _dY, double _dW, double _dH, int _iMaxLen, TextAlignment _Align)
        {

            /////////////////////////////////////////////////////////////
            //TEXTBOX
            this.m_TextBox = new TextBox();
            this.m_TextBox.Text = "This is a vertically centered one-line textbox embedded in a border...";
            Canvas.SetLeft(this, _dX);
            Canvas.SetTop(this, _dY);
            this.m_TextBox.FontFamily = new FontFamily("Consolas");
            this.m_TextBox.FontSize = 11;
            this.m_TextBox.Background = this.m_Brush_Black;
            this.m_TextBox.Foreground = this.m_Brush_Green;
            this.m_TextBox.BorderBrush = this.m_Brush_Transparent;
            this.m_TextBox.BorderThickness = new Thickness(0.0);
            this.m_TextBox.Width = _dW;
            this.m_TextBox.MaxLength = _iMaxLen;
            this.m_TextBox.TextAlignment = _Align;
            this.m_TextBox.VerticalAlignment = System.Windows.VerticalAlignment.Center;
            this.m_TextBox.FocusVisualStyle = null;
            this.m_TextBox.Margin = new Thickness(3.0);
            this.m_TextBox.CaretBrush = this.m_Brush_Green;
            this.m_TextBox.SelectionBrush = this.m_Brush_Green;
            this.m_TextBox.SelectionOpacity = 0.3;

            this.m_TextBox.GotFocus += this.CZ3r0_TextBox_GotFocus;
            this.m_TextBox.LostFocus += this.CZ3r0_TextBox_LostFocus;
            /////////////////////////////////////////////////////////////
            //BORDER

            this.BorderBrush = this.m_Brush_Transparent;
            this.BorderThickness = new Thickness(1.0);
            this.Background = this.m_Brush_Black;            
            this.Height = _dH;
            this.Child = this.m_TextBox;
            this.FocusVisualStyle = null;
            this.MouseDown += this.CZ3r0_TextBox_MouseDown;
            this.Cursor = Cursors.IBeam;
            /////////////////////////////////////////////////////////////
        }
        private void CZ3r0_TextBox_MouseDown(object _Sender, MouseEventArgs e)
        {
            this.m_TextBox.Focus();
        }
        private void CZ3r0_TextBox_GotFocus(object _Sender, RoutedEventArgs e)
        {
            this.BorderBrush = this.m_Brush_Green;
        }
        private void CZ3r0_TextBox_LostFocus(object _Sender, RoutedEventArgs e)
        {
            this.BorderBrush = this.m_Brush_Transparent;
        }
    }
}