你可以在python中使用sed、awk或grep(有一些限制)。这里有一个非常简单的例子。它在文件中把香蕉变成香蕉牙膏。你可以编辑和使用它。(我测试过了…注意:如果你在Windows下测试，你应该先安装sed命令并设置路径)

import os 
file="a.txt"
oldtext="Banana"
newtext=" BananaToothpaste"
os.system('sed -i "s/{}/{}/g" {}'.format(oldtext,newtext,file))
#print(f'sed -i "s/{oldtext}/{newtext}/g" {file}')
print('This command was applied:  sed -i "s/{}/{}/g" {}'.format(oldtext,newtext,file))

如果你想直接在文件上看到结果，应用:"type" for windows/ "cat" for linux:

####FOR WINDOWS:
os.popen("type " + file).read()
####FOR LINUX:
os.popen("cat " + file).read()

Besides the answers already mentioned, here is an explanation of why you have some random characters at the end: You are opening the file in r+ mode, not w mode. The key difference is that w mode clears the contents of the file as soon as you open it, whereas r+ doesn't. This means that if your file content is "123456789" and you write "www" to it, you get "www456789". It overwrites the characters with the new input, but leaves any remaining input untouched. You can clear a section of the file contents by using truncate(<startPosition>), but you are probably best off saving the updated file content to a string first, then doing truncate(0) and writing it all at once. Or you can use my library :D

正如Jack Aidley发布的和J.F. Sebastian指出的那样，这个代码是行不通的:

 # Read in the file
filedata = None
with file = open('file.txt', 'r') :
  filedata = file.read()

# Replace the target string
filedata.replace('ram', 'abcd')

# Write the file out again
with file = open('file.txt', 'w') :
  file.write(filedata)`

但这段代码将工作(我已经测试过了):

f = open(filein,'r')
filedata = f.read()
f.close()

newdata = filedata.replace("old data","new data")

f = open(fileout,'w')
f.write(newdata)
f.close()

使用此方法，fileein和fileout可以是同一个文件，因为Python 3.3将在打开进行写入时覆盖该文件。

我试过用readline代替read

with open('dummy.txt','r') as file:
    list = file.readlines()
print(f'before removal {list}')
for i in list[:]:
        list.remove(i)

print(f'After removal {list}')
with open('dummy.txt','w+') as f:
    for i in list:
        f.write(i)

我已经把这个作为一个课程的练习:打开文件，找到并替换字符串，并写入一个新文件。

class Letter:

    def __init__(self):

        with open("./Input/Names/invited_names.txt", "r") as file:
            # read the list of names
            list_names = [line.rstrip() for line in file]
            with open("./Input/Letters/starting_letter.docx", "r") as f:
                # read letter
                file_source = f.read()
            for name in list_names:
                with open(f"./Output/ReadyToSend/LetterTo{name}.docx", "w") as f:
                    # replace [name] with name of the list in the file
                    replace_string = file_source.replace('[name]', name)
                    # write to a new file
                    f.write(replace_string)


brief = Letter()

我稍微修改了Jayram Singh的帖子，以替换每一个'!'字符转换为一个数字，我想在每个实例中增加这个数字。我想这对那些想要修改每行出现不止一次的字符并且想要迭代的人可能会有帮助。希望这能帮助到别人。PS-我在编码方面很新，所以如果我的帖子在任何方面都不合适，我很抱歉，但这对我来说是有效的。

f1 = open('file1.txt', 'r')
f2 = open('file2.txt', 'w')
n = 1  

# if word=='!'replace w/ [n] & increment n; else append same word to     
# file2

for line in f1:
    for word in line:
        if word == '!':
            f2.write(word.replace('!', f'[{n}]'))
            n += 1
        else:
            f2.write(word)
f1.close()
f2.close()